Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ndidi Ese Uzor"'
Autor:
Krystal English, Andrew Shepherd, Ndidi-Ese Uzor, Ronnie Trinh, Annemieke Kavelaars, Cobi J. Heijnen
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-14 (2020)
Abstract Neurodegenerative disorders, including chemotherapy-induced cognitive impairment, are associated with neuronal mitochondrial dysfunction. Cisplatin, a commonly used chemotherapeutic, induces neuronal mitochondrial dysfunction in vivo and in
Externí odkaz:
https://doaj.org/article/25ca49647ebc4517838833a5d4c7449b
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Peroxisomes exist in most cells, where they participate in lipid metabolism, as well as scavenging the reactive oxygen species (ROS) that are produced as by-products of their metabolic functions. In certain tissues such as the liver and kidneys, pero
Externí odkaz:
https://doaj.org/article/1b1cc8b3eea04e37b8af0a53d4f17d4f
Autor:
Andrew J. Shepherd, Ronnie Trinh, Krystal English, Annemieke Kavelaars, Cobi J. Heijnen, Ndidi Ese Uzor
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-14 (2020)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Neurodegenerative disorders, including chemotherapy-induced cognitive impairment, are associated with neuronal mitochondrial dysfunction. Cisplatin, a commonly used chemotherapeutic, induces neuronal mitochondrial dysfunction in vivo and in vitro. As
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bdbe833edf6a0bc7392d83044b65334
http://link.springer.com/article/10.1186/s40478-020-00897-7
http://link.springer.com/article/10.1186/s40478-020-00897-7
Autor:
Aleah Holmes, Jessica M. Stephenson, Andrey S. Tsvetkov, Caroline R. Reynolds, Gab Seok Kim, Liang Zhu, Ndidi-Ese Uzor, Diego A Morales Scheihing, Louise D. McCullough, Jose F. Moruno-Manchon
Publikováno v:
Mol Cell Neurosci
Peroxisomes exist in nearly every cell, oxidizing fats, synthesizing lipids and maintaining redox balance. As the brain ages, multiple pathways are negatively affected, but it is currently unknown if peroxisomal proteins are affected by aging in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84cd1330f309599bec9f3cfcac02b753
https://pubmed.ncbi.nlm.nih.gov/32777345
https://pubmed.ncbi.nlm.nih.gov/32777345
Autor:
Andrey S. Tsvetkov, Debra M. Townley, Sunila Pradeep, Jose F. Moruno-Manchon, Shelli R. Kesler, Lingegowda S. Mangala, Archana S. Nagaraja, Anil K. Sood, Jeffrey S. Wefel, Ndidi Ese Uzor
Publikováno v:
Molecular and Cellular Neuroscience. 86:65-71
Doxorubicin, a commonly used anti-neoplastic agent, causes severe neurotoxicity. Doxorubicin promotes thinning of the brain cortex and accelerates brain aging, leading to cognitive impairment. Oxidative stress induced by doxorubicin contributes to ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea6858a5f5ab867fcf15f4178ee5f79c
https://doi.org/10.1016/j.mcn.2017.11.014
https://doi.org/10.1016/j.mcn.2017.11.014
Autor:
Debra M. Townley, Sunila Pradeep, Shelli R. Kesler, Anil K. Sood, Ndidi-Ese Uzor, Lingegowda S. Mangala, Andrey S. Tsvetkov, Jose F. Moruno-Manchon, Archana S. Nagaraja, Jeffrey S. Wefel
Publikováno v:
Aging (Albany NY)
Doxorubicin, a commonly used chemotherapy agent, induces severe cardio- and neurotoxicity. Molecular mechanisms of cardiotoxicity have been extensively studied, but mechanisms by which doxorubicin exhibits its neurotoxic properties remain unclear. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5ca1454b6ac042a640689c07e14eec
https://doi.org/10.18632/aging.101144
https://doi.org/10.18632/aging.101144
Publikováno v:
Autophagy, vol 12, iss 8
Although implicated in neurodegeneration, autophagy has been characterized mostly in yeast and mammalian non-neuronal cells. In a recent study, we sought to determine if SPHK1 (sphingosine kinase 1), implicated previously in macroautophagy/autophagy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f0c0fd059246dab7a0f54f481e34e21
https://doi.org/10.1080/15548627.2016.1183082
https://doi.org/10.1080/15548627.2016.1183082
Autor:
Vivekananda Shetty, Chinnaswamy Jagannath, Chandrashekar R. Ambati, Jose F. Moruno-Manchon, Nagireddy Putluri, Louise D. McCullough, Andrey S. Tsvetkov, Ndidi Ese Uzor
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 9, Iss 5, Pp 1-13 (2018)
Cell Death and Disease, Vol 9, Iss 5, Pp 1-13 (2018)
Autophagy is a degradative pathway for removing aggregated proteins, damaged organelles, and parasites. Evidence indicates that autophagic pathways differ between cell types. In neurons, autophagy plays a homeostatic role, compared to a survival mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f50a0708d84e620cad32352cc5777791
https://pubmed.ncbi.nlm.nih.gov/29743513
https://pubmed.ncbi.nlm.nih.gov/29743513
Autor:
Nagireddy Putluri, Ndidi-Ese Uzor, Andrey S. Tsvetkov, Maria P. Blasco-Conesa, Jose F. Moruno-Manchon, Erin Furr-Stimming, Sishira Mannuru
Huntington disease (HD) is the most common inherited neurodegenerative disorder. It has no cure. The protein huntingtin causes HD, and mutations to it confer toxic functions to the protein that lead to neurodegeneration. Thus, identifying modifiers o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94ed3d3d29fdbeea6f7fea827e28cf9
https://europepmc.org/articles/PMC6251541/
https://europepmc.org/articles/PMC6251541/
Autor:
Yuri Dabaghian, Jose Felix Moruno Manchon, Shelli R. Kesler, Jeffrey S. Wefel, Ndidi Ese Uzor, Andrey S. Tsvetkov
Publikováno v:
Scientific Reports
Neurotoxicity may occur in cancer patients and survivors during or after chemotherapy. Cognitive deficits associated with neurotoxicity can be subtle or disabling and frequently include disturbances in memory, attention, executive function and proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce96b77d354c702f16dc59a119cc4be
https://doi.org/10.1038/srep25705
https://doi.org/10.1038/srep25705