Synergistic Interaction Between High Bioactive IL-17A and Joint Destruction for the Occurrence of Cardiovascular Events in Rheumatoid Arthritis

Autor: Marie Robert, Arnaud Hot, François Mifsud, Ndiémé Ndongo-Thiam, Pierre Miossec

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Rheumatoid arthritis (RA) remains a cause of morbidity and mortality in many patients while new treatments have changed the face of the disease. Despite the emergence of these new drugs, cardiovascular (CV) diseases remain more frequent in RA patient

Externí odkaz: https://doaj.org/article/cdf1b7cc0d9c4decbda7cff1e49bf444

Role of podoplanin in the high interleukin-17A secretion resulting from interactions between activated lymphocytes and psoriatic skin-derived mesenchymal cells

Autor: Mélissa Noack, Ndiémé Ndongo-Thiam, Pierre Miossec

Publikováno v: Clinical and Experimental Immunology. 186:64-74

Summary In the context of psoriasis, T helper type 17 (Th17) cells infiltrate the inflammatory site and interact with local mesenchymal cells, including skin fibroblasts. The aim of this work was to study the interactions of skin-derived fibroblasts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68efccc843c5b10a1854e51adbe04491
https://doi.org/10.1111/cei.12830

03.02 Evaluation of anti-inflammatory effects of steroids and arthritis-related biotherapies in an in vitro co-culture model with immune cells and synoviocytes

Autor: Ndiémé Ndongo-Thiam, Mélissa Noack, Pierre Miossec

Publikováno v: Immune regulation.

Background During rheumatoid arthritis (RA), steroids and biotherapies are two different ways to diminish inflammation, by reducing cytokine production and they are used alone and combined. Their efficacy has been established in clinical trials but t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::620918ae94bb1c946ca461996274346f
https://doi.org/10.1136/annrheumdis-2016-211049.2

Evaluation of Anti-inflammatory Effects of Steroids and Arthritis-Related Biotherapies in an

Autor: Mélissa, Noack, Ndiémé, Ndongo-Thiam, Pierre, Miossec

Publikováno v: Frontiers in Immunology

Background During rheumatoid arthritis (RA), steroids and biotherapies are used alone and combined. Efficacy has been established in clinical trials but their differential effects at the cellular level are less documented. The aim was to study these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::62be4041d717b259bca35b669340c8e8
https://pubmed.ncbi.nlm.nih.gov/27909436

IgM rheumatoid factor amplifies the inflammatory response of macrophages induced by the rheumatoid arthritis-specific immune complexes containing anticitrullinated protein antibodies

Autor: Cyril Clavel, Guy Serre, Géraldine Offer, Mireille Sebbag, Lætitia Laurent, Pierre Miossec, Florence Anquetil, JL Pasquali, Ndiémé Ndongo-Thiam

Publikováno v: Annals of the Rheumatic Diseases
Annals of the Rheumatic Diseases, BMJ Publishing Group, 2015, 74 (7), pp.1425-1431. ⟨10.1136/annrheumdis-2013-204543⟩

ObjectivesAnticitrullinated protein antibodies (ACPA) are specifically associated with rheumatoid arthritis (RA) and produced in inflamed synovial membranes where citrullinated fibrin, their antigenic target, is abundant. We showed that immune comple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26795e3e4daf3fac3e33225e8bafbcdb
https://hal-univ-tlse3.archives-ouvertes.fr/hal-03154842