Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Nchimunya N. Tebeka"'
Autor:
Anna Veprik, Geoffrey Denwood, Dong Liu, Rula Bany Bakar, Valentin Morfin, Kara McHugh, Nchimunya N. Tebeka, Laurène Vetterli, Ekaterina Yonova-Doing, Fiona Gribble, Frank Reimann, Kyle L. Hoehn, Piers A. Hemsley, Jonas Ahnfelt-Rønne, Patrik Rorsman, Quan Zhang, Heidi de Wet, James Cantley
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Veprik et al. show that Acetyl-CoA-carboxylase 1 (ACC1), an enzyme that couples glucose metabolism to lipogenesis, is involved in glucagon secretion and regulates S-acylation of critical glucose-sensing proteins. Loss of ACC1 in pancreatic alpha-cell
Externí odkaz:
https://doaj.org/article/166afa66325d42c88ebcf56718483f72
Autor:
Anna Veprik, Bruce E. Kemp, James Cantley, Rula Bany Bakar, Sabrina Liberatori, Shabaz Mohammed, Nchimunya N. Tebeka
Publikováno v:
Diabetes. 70
Aims: ACC1 couples glucose metabolism with de novo lipogenesis in lipogenic tissues, by converting acetyl-CoA to malonyl-CoA. In β-cells, ACC1 plays a critical role in β-cell growth and insulin secretion. However, very little is known about ACC1 re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f22672c5d33d21ea86d2a97048651716
https://doi.org/10.2337/db21-1256-p
https://doi.org/10.2337/db21-1256-p
Autor:
Reichhardt MP; Sir William Dunn School of Pathology, University of Oxford, OX1 3RE Oxford, United Kingdom., Johnson S; Sir William Dunn School of Pathology, University of Oxford, OX1 3RE Oxford, United Kingdom., Tang T; Sir William Dunn School of Pathology, University of Oxford, OX1 3RE Oxford, United Kingdom., Morgan T; Sir William Dunn School of Pathology, University of Oxford, OX1 3RE Oxford, United Kingdom., Tebeka N; Sir William Dunn School of Pathology, University of Oxford, OX1 3RE Oxford, United Kingdom., Popitsch N; Wellcome Centre for Human Genetics, University of Oxford, OX3 7BN Oxford, United Kingdom., Deme JC; Sir William Dunn School of Pathology, University of Oxford, OX1 3RE Oxford, United Kingdom.; Central Oxford Structural Molecular Imaging Centre, University of Oxford, OX1 3RE Oxford, United Kingdom., Jore MM; Sir William Dunn School of Pathology, University of Oxford, OX1 3RE Oxford, United Kingdom., Lea SM; Sir William Dunn School of Pathology, University of Oxford, OX1 3RE Oxford, United Kingdom; susan.lea@path.ox.ac.uk.; Central Oxford Structural Molecular Imaging Centre, University of Oxford, OX1 3RE Oxford, United Kingdom.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jan 07; Vol. 117 (1), pp. 362-370. Date of Electronic Publication: 2019 Dec 23.