Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion

Autor: Anna Veprik, Geoffrey Denwood, Dong Liu, Rula Bany Bakar, Valentin Morfin, Kara McHugh, Nchimunya N. Tebeka, Laurène Vetterli, Ekaterina Yonova-Doing, Fiona Gribble, Frank Reimann, Kyle L. Hoehn, Piers A. Hemsley, Jonas Ahnfelt-Rønne, Patrik Rorsman, Quan Zhang, Heidi de Wet, James Cantley

Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)

Veprik et al. show that Acetyl-CoA-carboxylase 1 (ACC1), an enzyme that couples glucose metabolism to lipogenesis, is involved in glucagon secretion and regulates S-acylation of critical glucose-sensing proteins. Loss of ACC1 in pancreatic alpha-cell

Externí odkaz: https://doaj.org/article/166afa66325d42c88ebcf56718483f72

Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion.

Autor: Veprik, Anna^1,2 (AUTHOR), Denwood, Geoffrey³ (AUTHOR), Liu, Dong^1,4 (AUTHOR), Bany Bakar, Rula¹ (AUTHOR), Morfin, Valentin⁴ (AUTHOR), McHugh, Kara⁵ (AUTHOR), Tebeka, Nchimunya N.^1,4 (AUTHOR), Vetterli, Laurène¹ (AUTHOR), Yonova-Doing, Ekaterina² (AUTHOR), Gribble, Fiona⁶ (AUTHOR), Reimann, Frank⁶ (AUTHOR), Hoehn, Kyle L.⁷ (AUTHOR), Hemsley, Piers A.^5,8 (AUTHOR), Ahnfelt-Rønne, Jonas⁹ (AUTHOR), Rorsman, Patrik³ (AUTHOR), Zhang, Quan³ (AUTHOR), de Wet, Heidi¹ (AUTHOR), Cantley, James^1,4 (AUTHOR) jcantley001@dundee.ac.uk

Publikováno v: Communications Biology. 3/18/2022, Vol. 5 Issue 1, p1-13. 13p.