Zobrazeno 1 - 10
of 256
pro vyhledávání: '"Nazzareno Re"'
Publikováno v:
Molecules, Vol 29, Iss 15, p 3600 (2024)
Polarization and charge-transfer interactions play an important role in ligand–receptor complexes containing metals, and only quantum mechanics methods can adequately describe their contribution to the binding energy. In this work, we selected a se
Externí odkaz:
https://doaj.org/article/a5d5562447b342e09b5fdebd6b45df1e
Autor:
Iogann Tolbatov, Damiano Cirri, Lorella Marchetti, Alessandro Marrone, Cecilia Coletti, Nazzareno Re, Diego La Mendola, Luigi Messori, Tiziano Marzo, Chiara Gabbiani, Alessandro Pratesi
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Au(PEt3)I (AF-I hereafter), the iodide analog of the FDA-approved drug auranofin (AF hereafter), is a promising anticancer agent that produces its pharmacological effects through interaction with non-genomic targets such as the thioredoxin reductase
Externí odkaz:
https://doaj.org/article/80d53dd7b0e24fbabdfa02fc233254b9
Publikováno v:
Molecules, Vol 26, Iss 24, p 7600 (2021)
Owing to the growing hardware capabilities and the enhancing efficacy of computational methodologies, computational chemistry approaches have constantly become more important in the development of novel anticancer metallodrugs. Besides traditional Pt
Externí odkaz:
https://doaj.org/article/07bc930fb2924d77be452fd61f307f7a
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168039 (2016)
The propensity of cellular prion protein to aggregation is reputed essential for the initiation of the amyloid cascade that ultimately lead to the accumulation of neurotoxic aggregates. In this paper, we extended and applied an already reported compu
Externí odkaz:
https://doaj.org/article/972d0693d89c49878466f24e17f1fb72
Autor:
Sacha Sorrentino, Tonino Bucciarelli, Alessandro Corsaro, Alessio Tosatto, Stefano Thellung, Valentina Villa, M Eugenia Schininà, Bruno Maras, Roberta Galeno, Luca Scotti, Francesco Creati, Alessandro Marrone, Nazzareno Re, Antonio Aceto, Tullio Florio, Michele Mazzanti
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e38314 (2012)
The pathological form of prion protein (PrP(Sc)), as other amyloidogenic proteins, causes a marked increase of membrane permeability. PrP(Sc) extracted from infected Syrian hamster brains induces a considerable change in membrane ionic conductance, a
Externí odkaz:
https://doaj.org/article/ead178485c6b4a2694955f62460f34ad
Autor:
Ana Paula Martins, Alessandro Marrone, Antonella Ciancetta, Ana Galán Cobo, Miriam Echevarría, Teresa F Moura, Nazzareno Re, Angela Casini, Graça Soveral
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37435 (2012)
Aquaporins (AQPs) are membrane channels that conduct water and small solutes such as glycerol and are involved in many physiological functions. Aquaporin-based modulator drugs are predicted to be of broad potential utility in the treatment of several
Externí odkaz:
https://doaj.org/article/f4753a037e294c6eaa7f90b6469ea42d
Autor:
David C. Goldstone, Nazzareno Re, Matthew P. Sullivan, Ronald Gust, Christian G. Hartinger, Monika Cziferszky, Iogann Tolbatov, Davide Mercadante, Dianna Truong
Publikováno v:
Angewandte Chemie. 133:20081-20085
Metal complexes can be considered a "paradigm of promiscuity" when it comes to their interactions with proteins. They often form adducts with a variety of donor atoms in an unselective manner. We have characterized the adducts formed between a series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e53fd2a1c7e58736205f468b7abcf0e
https://doi.org/10.1002/ange.202106906
https://doi.org/10.1002/ange.202106906
Autor:
Davide Corinti, Roberto Paciotti, Cecilia Coletti, Nazzareno Re, Barbara Chiavarino, Maria Elisa Crestoni, Simonetta Fornarini
Publikováno v:
Journal of inorganic biochemistry. 237
The reactivity of a widely used metal based antineoplastic drug, cisplatin, cis-PtCl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c356295b133fd900e77c8cb4fb49fb1c
https://pubmed.ncbi.nlm.nih.gov/36209532
https://pubmed.ncbi.nlm.nih.gov/36209532
Autor:
Emma Baglini, Claudia Martini, Elisabetta Giorgini, Nazzareno Re, Valentina Notarstefano, Elisabetta Barresi, Iogann Tolbatov, Federico Da Settimo, Sabrina Taliani, Tiziano Marzo, Simona Daniele, Alessandro Pratesi, Diego La Mendola
Publikováno v:
Dalton Transactions. 49:14520-14527
We herein report the synthesis and multi-technique characterization of [Ru2Cl((2-phenylindol-3-yl)glyoxyl-l-leucine-l-phenylalanine)4], a novel diruthenium(ii,iii) complex obtained by reacting [Ru2(μ-O2CCH3)4Cl] with a dual indolylglyoxylyl dipeptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef54268167463f1bd3265875969638d
https://doi.org/10.1039/d0dt02527e
https://doi.org/10.1039/d0dt02527e
Autor:
Iogann Tolbatov, Damiano Cirri, Matteo Tarchi, Tiziano Marzo, Cecilia Coletti, Alessandro Marrone, Luigi Messori, Nazzareno Re, Lara Massai
Publikováno v:
Inorganic chemistry. 61(7)
Arsenoplatin-1 (AP-1) is a dual-action anticancer metallodrug with a promising pharmacological profile that features the simultaneous presence of a cisplatin-like center and an arsenite center. We investigated its interactions with proteins through a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2222af4580b471d0f7b4cd56ad79853
https://pubmed.ncbi.nlm.nih.gov/35137586
https://pubmed.ncbi.nlm.nih.gov/35137586