Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Nazli Khodayari"'
Autor:
Nazli Khodayari, Regina Oshins, Borna Mehrad, Jorge E Lascano, Xiao Qiang, Jesse R West, L Shannon Holliday, Jungnam Lee, Gayle Wiesemann, Soroush Eydgahi, Mark Brantly
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/30867674eb6a447eb9255d6b7ddca162
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-10 (2023)
Abstract Background Alpha-1-antitrypsin deficient (AATD) individuals are prone to develop early age of onset chronic obstructive pulmonary disease (COPD) more severe than non-genetic COPD. Here, we investigated the characteristics of lower respirator
Externí odkaz:
https://doaj.org/article/1064e308d14844758810e52c5d228ea7
Autor:
Nazli Khodayari, Regina Oshins, Borna Mehrad, Jorge E. Lascano, Xiao Qiang, Jesse R. West, L. Shannon Holliday, Jungnam Lee, Gayle Wiesemann, Soroush Eydgahi, Mark Brantly
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-14 (2022)
Abstract Background Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder most commonly secondary to a single mutation in the SERPINA1 gene (PI*Z) that causes misfolding and accumulation of alpha-1 antitrypsin (AAT) in hepatocytes and mononucle
Externí odkaz:
https://doaj.org/article/aeed486998b841e0a8aa558b3197c121
Autor:
Yuanqing Lu, Liqun R. Wang, Jungnam Lee, Naweed S. Mohammad, Alek M. Aranyos, Calvin Gould, Nazli Khodayari, Regina A. Oshins, Craig G. Moneypenny, Mark L. Brantly
Publikováno v:
Hepatology Communications, Vol 6, Iss 9, Pp 2354-2367 (2022)
Abstract Alpha‐1 antitrypsin (AAT) deficiency (AATD) is an inherited disease caused by mutations in the serpin family A member 1 (SERPINA1, also known as AAT) gene. The most common variant, PI*Z (Glu342Lys), causes accumulation of aberrantly folded
Externí odkaz:
https://doaj.org/article/92a570ec9b614164988c135754ba0ab1
Autor:
Robert Hromas, Gayathri Srinivasan, Ming Yang, Aruna Jaiswal, Taylor A. Totterdale, Linda Phillips, Austin Kirby, Nazli Khodayari, Mark Brantley, Elizabeth A. Williamson, Kimi Y. Kong
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105626- (2022)
Summary: Tumors with BRCA1 mutations have poor prognoses due to genomic instability. Yet this genomic instability has risks and BRCA1-deficient (def) cancer cells must develop pathways to mitigate these risks. One such risk is the accumulation of unf
Externí odkaz:
https://doaj.org/article/6b585162ceff4b129704e1d38d531e80
Autor:
Nazli Khodayari, Regina Oshins, L. Shannon Holliday, Virginia Clark, Qiang Xiao, George Marek, Borna Mehrad, Mark Brantly
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-18 (2020)
Abstract Background Alpha-1 antitrypsin deficiency (AATD)-mediated liver disease is a toxic “gain-of-function” inflammation in the liver associated with intracellular retention of mutant alpha-1 antitrypsin. The clinical presentation of the disea
Externí odkaz:
https://doaj.org/article/13d3bdcdd4f04dbfafa8102f6f4ffa10
Autor:
Jorge Lascano, Regina Oshins, Christina Eagan, Zerka Wadood, Xiao Qiang, Tammy Flagg, Yogesh Scindia, Borna Mehrad, Mark Brantly, Nazli Khodayari
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0274427 (2022)
BackgroundSevere acute respiratory syndrome caused by a novel coronavirus 2 (SARS-CoV-2) has infected more than 18 million people worldwide. The activation of endothelial cells is a hallmark of signs of SARS-CoV-2 infection that includes altered inte
Externí odkaz:
https://doaj.org/article/0af4d479e9b540bdb89bff1f99f0836f
Autor:
Yuanqing Lu, Liqun R. Wang, Jungnam Lee, Naweed S. Mohammad, Alek M. Aranyos, Calvin Gould, Nazli Khodayari, Regina A. Oshins, Craig G. Moneypenny, Mark L. Brantly
Publikováno v:
Hepatology Communications, Vol 6, Iss 12, Pp 3599-3599 (2022)
Externí odkaz:
https://doaj.org/article/e758c06df716477ea50c039fab07cca4
Autor:
Nazli Khodayari, Rejean Liqun Wang, George Marek, Karina Krotova, Mariana Kirst, Chen Liu, Farshid Rouhani, Mark Brantly
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0172983 (2017)
Alpha-1 antitrypsin deficiency (AATD) is an inherited disorder characterized by early-onset emphysema and liver disease. The most common disease-causing mutation is a single amino acid substitution (Glu/Lys) at amino acid 342 of the mature protein, r
Externí odkaz:
https://doaj.org/article/d03a76a194f74cfc883f24c05b210fc1
Publikováno v:
Journal of Rehabilitation, Vol 4, Iss 2, Pp 16-19 (2003)
Objective: Dysfunction of the central dopaminergic neurotransmission has been suggested to play an important role in the etiology of schizophrenia. The dopamine transporter (DAT1) mediates the active reuptake of dopamine from the synapses and thereby
Externí odkaz:
https://doaj.org/article/fe8352341ba644919af7fd800c762ee9