Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Nazli, Khodayari"'
Autor:
Nazli Khodayari, Regina Oshins, Borna Mehrad, Jorge E Lascano, Xiao Qiang, Jesse R West, L Shannon Holliday, Jungnam Lee, Gayle Wiesemann, Soroush Eydgahi, Mark Brantly
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/30867674eb6a447eb9255d6b7ddca162
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-10 (2023)
Abstract Background Alpha-1-antitrypsin deficient (AATD) individuals are prone to develop early age of onset chronic obstructive pulmonary disease (COPD) more severe than non-genetic COPD. Here, we investigated the characteristics of lower respirator
Externí odkaz:
https://doaj.org/article/1064e308d14844758810e52c5d228ea7
Autor:
Nazli Khodayari, Regina Oshins, Borna Mehrad, Jorge E. Lascano, Xiao Qiang, Jesse R. West, L. Shannon Holliday, Jungnam Lee, Gayle Wiesemann, Soroush Eydgahi, Mark Brantly
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-14 (2022)
Abstract Background Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder most commonly secondary to a single mutation in the SERPINA1 gene (PI*Z) that causes misfolding and accumulation of alpha-1 antitrypsin (AAT) in hepatocytes and mononucle
Externí odkaz:
https://doaj.org/article/aeed486998b841e0a8aa558b3197c121
Autor:
Yuanqing Lu, Liqun R. Wang, Jungnam Lee, Naweed S. Mohammad, Alek M. Aranyos, Calvin Gould, Nazli Khodayari, Regina A. Oshins, Craig G. Moneypenny, Mark L. Brantly
Publikováno v:
Hepatology Communications, Vol 6, Iss 9, Pp 2354-2367 (2022)
Abstract Alpha‐1 antitrypsin (AAT) deficiency (AATD) is an inherited disease caused by mutations in the serpin family A member 1 (SERPINA1, also known as AAT) gene. The most common variant, PI*Z (Glu342Lys), causes accumulation of aberrantly folded
Externí odkaz:
https://doaj.org/article/92a570ec9b614164988c135754ba0ab1
Autor:
Robert Hromas, Gayathri Srinivasan, Ming Yang, Aruna Jaiswal, Taylor A. Totterdale, Linda Phillips, Austin Kirby, Nazli Khodayari, Mark Brantley, Elizabeth A. Williamson, Kimi Y. Kong
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105626- (2022)
Summary: Tumors with BRCA1 mutations have poor prognoses due to genomic instability. Yet this genomic instability has risks and BRCA1-deficient (def) cancer cells must develop pathways to mitigate these risks. One such risk is the accumulation of unf
Externí odkaz:
https://doaj.org/article/6b585162ceff4b129704e1d38d531e80
Autor:
Nazli Khodayari, Regina Oshins, L. Shannon Holliday, Virginia Clark, Qiang Xiao, George Marek, Borna Mehrad, Mark Brantly
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-18 (2020)
Abstract Background Alpha-1 antitrypsin deficiency (AATD)-mediated liver disease is a toxic “gain-of-function” inflammation in the liver associated with intracellular retention of mutant alpha-1 antitrypsin. The clinical presentation of the disea
Externí odkaz:
https://doaj.org/article/13d3bdcdd4f04dbfafa8102f6f4ffa10
Autor:
Jorge Lascano, Regina Oshins, Christina Eagan, Zerka Wadood, Xiao Qiang, Tammy Flagg, Yogesh Scindia, Borna Mehrad, Mark Brantly, Nazli Khodayari
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0274427 (2022)
BackgroundSevere acute respiratory syndrome caused by a novel coronavirus 2 (SARS-CoV-2) has infected more than 18 million people worldwide. The activation of endothelial cells is a hallmark of signs of SARS-CoV-2 infection that includes altered inte
Externí odkaz:
https://doaj.org/article/0af4d479e9b540bdb89bff1f99f0836f
Autor:
Yuanqing Lu, Liqun R. Wang, Jungnam Lee, Naweed S. Mohammad, Alek M. Aranyos, Calvin Gould, Nazli Khodayari, Regina A. Oshins, Craig G. Moneypenny, Mark L. Brantly
Publikováno v:
Hepatology Communications, Vol 6, Iss 12, Pp 3599-3599 (2022)
Externí odkaz:
https://doaj.org/article/e758c06df716477ea50c039fab07cca4
Autor:
Nazli Khodayari, Regina Oshins, Alek M. Aranyos, Sergio Duarte, Sayedamin Mostofizadeh, Yuanqing Lu, Mark Brantly
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 323:G594-G608
Alpha-1 antitrypsin deficiency (AATD) is a genetic disease caused by a hepatic accumulation of mutant alpha-1 antitrypsin (ZAAT). Individuals with AATD are prone to develop a chronic liver disease that remains undiagnosed until late stage of the dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c995be27dafd1eb243c29c82c91428bd
https://doi.org/10.1152/ajpgi.00207.2022
https://doi.org/10.1152/ajpgi.00207.2022
Autor:
Nazli Khodayari, Rejean Liqun Wang, George Marek, Karina Krotova, Mariana Kirst, Chen Liu, Farshid Rouhani, Mark Brantly
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0172983 (2017)
Alpha-1 antitrypsin deficiency (AATD) is an inherited disorder characterized by early-onset emphysema and liver disease. The most common disease-causing mutation is a single amino acid substitution (Glu/Lys) at amino acid 342 of the mature protein, r
Externí odkaz:
https://doaj.org/article/d03a76a194f74cfc883f24c05b210fc1