In silico model of the human ClC-Kb chloride channel: pore mapping, biostructural pathology and drug screening

Autor: Maxime Louet, Sara Bitam, Naziha Bakouh, Yohan Bignon, Gabrielle Planelles, David Lagorce, Maria A. Miteva, Dominique Eladari, Jacques Teulon, Bruno O. Villoutreix

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)

Abstract The human ClC-Kb channel plays a key role in exporting chloride ions from the cytosol and is known to be involved in Bartter syndrome type 3 when its permeation capacity is decreased. The ClC-Kb channel has been recently proposed as a potent

Externí odkaz: https://doaj.org/article/4dc1bd937e734475b48e1b0e7b1ec36e

A variant of ASIC2 mediates sodium retention in nephrotic syndrome

Autor: Georges Deschênes, Marc Fila, Gabrielle Planelles, Pascal Houillier, Gilles Crambert, Alain Doucet, Michel Gennaoui, Christine Walter, Ignacio Anegon, Laure Collignon, Luciana Morla, Lydie Cheval, Gaëlle Brideau, Michel Peuchmaur, Mathilde Keck, Naziha Bakouh, Bruno Vogt, Séverine Remy, Ali Sassi

Publikováno v: JCI Insight
JCI Insight, American Society for Clinical Investigation, 2021, ⟨10.1172/jci.insight.148588⟩

Idiopathic nephrotic syndrome (INS) is characterized by proteinuria and renal sodium retention leading to edema. This sodium retention is usually attributed to epithelial sodium channel (ENaC) activation after plasma aldosterone increase. However, mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b5f837ec78f613893fe838935cf760
https://doi.org/10.1172/jci.insight.148588

Functional interaction between CFTR and the sodium-phosphate co-transport type 2a in Xenopus laevis oocytes.

Autor: Naziha Bakouh, Baya Chérif-Zahar, Philippe Hulin, Dominique Prié, Gérard Friedlander, Aleksander Edelman, Gabrielle Planelles

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e34879 (2012)

BackgroundA growing number of proteins, including ion transporters, have been shown to interact with Cystic Fibrosis Transmembrane conductance Regulator (CFTR). CFTR is an epithelial chloride channel that is involved in Cystic Fibrosis (CF) when muta

Externí odkaz: https://doaj.org/article/0fa24138658146a4b51424fe009f353a

Analysis of CLCNKB mutations at dimer-interface, calcium binding site and pore reveals a variety of functional alterations in ClC-Kb channel leading to Bartter syndrome

Autor: Marc Paulais, Imene Sakhi, Mathilde Keck, Yohan Bignon, Olga Andrini, Gabrielle Planelles, Naziha Bakouh, Sara Bitam, Nadia Frachon, Jacques Teulon

Publikováno v: Human Mutation
Human Mutation, Wiley, 2019, ⟨10.1002/humu.23962⟩
Human Mutation, Wiley, 2019, Epub ahead of print. ⟨10.1002/humu.23962⟩
Human Mutation, 2019, Epub ahead of print. ⟨10.1002/humu.23962⟩

International audience; Pathological missense mutations in CLCNKB gene give a wide spectrum of clinical phenotypes in Bartter syndrome type III patients. Molecular analysis of the mutated ClC-Kb channels can be helpful to classify the mutations accor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd979f820c555341b3a6bd2a94f9caf7
https://hal.archives-ouvertes.fr/hal-02397024

Iron is a substrate of the Plasmodium falciparum chloroquine resistance transporter PfCRT in Xenopus oocytes

Autor: Cecilia P. Sanchez, Zoubida Karim, Gabrielle Planelles, Wilfred D. Stein, Michael Lanzer, Sonia Moliner Cubel, Sebastiano Bellanca, Britta Nyboer, Naziha Bakouh

The chloroquine resistance transporter of the human malaria parasite Plasmodium falciparum, PfCRT, is an important determinant of resistance to several quinoline and quinoline-like antimalarial drugs. PfCRT also plays an essential role in the physiol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22477d2b0ec27fbae9c414e42f09d680
https://europepmc.org/articles/PMC5625042/