Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Nazif, Alic"'
Autor:
Mengjia Li, Haocheng Shou, Guillermo Martínez Corrales, Tatiana Svermova, Alessandra Vieira Franco, Nazif Alic
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109962- (2024)
Summary: Transcription factors can reprogram gene expression to promote longevity. Here, we investigate the role of Drosophila Xbp1. Xbp1 is activated by splicing of its primary transcript, Xbp1u, to generate Xbp1s, a key activator of the endoplasmic
Externí odkaz:
https://doaj.org/article/f18ff14b1908400a871d83a7709ddfbe
Autor:
Yavuz Kulaberoglu, Yasir Malik, Gillian Borland, Colin Selman, Nazif Alic, Jennifer M. A. Tullet
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/5670a13a26234bf9b5a49ab70779db22
Autor:
Yavuz Kulaberoglu, Yasir Malik, Gillian Borland, Colin Selman, Nazif Alic, Jennifer M. A. Tullet
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Transcription in eukaryotic cells is performed by three RNA polymerases. RNA polymerase I synthesises most rRNAs, whilst RNA polymerase II transcribes all mRNAs and many non-coding RNAs. The largest of the three polymerases is RNA polymerase III (Pol
Externí odkaz:
https://doaj.org/article/3cbd0c774462439e804744073e3a87c8
Autor:
Guillermo Martínez Corrales, Danny Filer, Katharina C. Wenz, Abbie Rogan, George Phillips, Mengjia Li, Yodit Feseha, Susan J. Broughton, Nazif Alic
Publikováno v:
Cell Reports, Vol 30, Iss 6, Pp 1661-1669.e4 (2020)
Summary: Health and survival in old age can be improved by changes in gene expression. RNA polymerase (Pol) I is the essential, conserved enzyme whose task is to generate the pre-ribosomal RNA (rRNA). We find that reducing the levels of Pol I activit
Externí odkaz:
https://doaj.org/article/5a3cb04f75484b25a4a2a11b3fd66f00
Autor:
Ekin Bolukbasi, Mobina Khericha, Jennifer C. Regan, Dobril K. Ivanov, Jennifer Adcott, Miranda C. Dyson, Tobias Nespital, Janet M. Thornton, Nazif Alic, Linda Partridge
Publikováno v:
Cell Reports, Vol 21, Iss 3, Pp 641-653 (2017)
Reduced activity of nutrient-sensing signaling networks can extend organismal lifespan, yet the underlying biology remains unclear. We show that the anti-aging effects of rapamycin and reduced intestinal insulin/insulin growth factor (IGF) signaling
Externí odkaz:
https://doaj.org/article/cce15e3e52c04e6f8d87a794625c2bc3
Autor:
Luke S Tain, Robert Sehlke, Chirag Jain, Manopriya Chokkalingam, Nagarjuna Nagaraj, Paul Essers, Mark Rassner, Sebastian Grönke, Jenny Froelich, Christoph Dieterich, Matthias Mann, Nazif Alic, Andreas Beyer, Linda Partridge
Publikováno v:
Molecular Systems Biology, Vol 13, Iss 9, Pp 1-19 (2017)
Abstract Lowered activity of the insulin/IGF signalling (IIS) network can ameliorate the effects of ageing in laboratory animals and, possibly, humans. Although transcriptome remodelling in long‐lived IIS mutants has been extensively documented, th
Externí odkaz:
https://doaj.org/article/b2ab6e59cb074d5c909331ce01d05a47
Autor:
Adam J. Dobson, Marina Ezcurra, Charlotte E. Flanagan, Adam C. Summerfield, Matthew D.W. Piper, David Gems, Nazif Alic
Publikováno v:
Cell Reports, Vol 18, Iss 2, Pp 299-306 (2017)
Summary: Consumption of unhealthy diets is exacerbating the burden of age-related ill health in aging populations. Such diets can program mammalian physiology to cause long-term, detrimental effects. Here, we show that, in Drosophila melanogaster, an
Externí odkaz:
https://doaj.org/article/2f8034f5e50b4e5f8f5dded8d9438fba
Autor:
Adam J Dobson, Richard Boulton-McDonald, Lara Houchou, Tatiana Svermova, Ziyu Ren, Jeremie Subrini, Mireya Vazquez-Prada, Mimoza Hoti, Maria Rodriguez-Lopez, Rita Ibrahim, Afroditi Gregoriou, Alexis Gkantiragas, Jürg Bähler, Marina Ezcurra, Nazif Alic
Publikováno v:
PLoS Genetics, Vol 15, Iss 7, p e1008212 (2019)
Ageing populations pose one of the main public health crises of our time. Reprogramming gene expression by altering the activities of sequence-specific transcription factors (TFs) can ameliorate deleterious effects of age. Here we explore how a circu
Externí odkaz:
https://doaj.org/article/d40fec961f234fed9ed5b2f38dc33346
Autor:
Guillermo Martínez Corrales, Mengjia Li, Tatiana Svermova, Alex Goncalves, Diana Voicu, Adam J. Dobson, Tony D. Southall, Nazif Alic
Publikováno v:
Nat Aging
A transient, homeostatic transcriptional response can result in transcriptional memory, programming subsequent transcriptional outputs. Transcriptional memory has great but unappreciated potential to alter animal ageing as animals encounter a multitu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c16d6a9851aabff623283fa66b4d7233
https://europepmc.org/articles/PMC7614430/
https://europepmc.org/articles/PMC7614430/
Autor:
Nazif Alic, Jennifer M. Tullet, Teresa Niccoli, Susan Broughton, Matthew P. Hoddinott, Cathy Slack, David Gems, Linda Partridge
Publikováno v:
Cell Reports, Vol 6, Iss 4, Pp 608-616 (2014)
Drosophila melanogaster and Caenorhabditis elegans each carry a single representative of the Forkhead box O (FoxO) family of transcription factors, dFOXO and DAF-16, respectively. Both are required for lifespan extension by reduced insulin/Igf signal
Externí odkaz:
https://doaj.org/article/b1f7e156bb1b4687852b1e07a9da0b64