Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Nazareno González"'
Autor:
L. Francisco Lorenzo-Martín, Natalia Fernández-Parejo, Mauricio Menacho-Márquez, Sonia Rodríguez-Fdez, Javier Robles-Valero, Sonia Zumalave, Salvatore Fabbiano, Gloria Pascual, Juana M. García-Pedrero, Antonio Abad, María C. García-Macías, Nazareno González, Pablo Lorenzano-Menna, Miguel A. Pavón, Rogelio González-Sarmiento, Carmen Segrelles, Jesús M. Paramio, José M. C. Tubío, Juan P. Rodrigo, Salvador A. Benitah, Myriam Cuadrado, Xosé R. Bustelo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
The Rho signalling pathway is frequently activated in squamous carcinomas. Here, the authors find that the Rho GEF VAV2 is over expressed in both cutaneous and head and neck squamous cell carcinomas and that at the molecular level VAV2 promotes a pro
Externí odkaz:
https://doaj.org/article/383992e6d52c41ef94a9df8bb7b4e08c
Autor:
Nazareno González, Georgina A. Cardama, Patricio Chinestrad, Javier Robles-Valero, Sonia Rodríguez-Fdez, L. Francisco Lorenzo-Martín, Xosé R. Bustelo, Pablo Lorenzano Menna, Daniel E. Gomez
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
In the last years, the development of new drugs in oncology has evolved notably. In particular, drug development has shifted from empirical screening of active cytotoxic compounds to molecularly targeted drugs blocking specific biologic pathways that
Externí odkaz:
https://doaj.org/article/f2d956e6c0694d8b9d53c1dc93810789
Autor:
Alejandro Javier Nicola Candia, Camila Florencia Zuccato, Adriana Seilicovich, Antonela Sofía Asad, Marianela Candolfi, Nazareno González
Publikováno v:
Current Medicinal Chemistry. 28:7729-7748
Background: Glioblastoma constitutes the most frequent and aggressive primary malignant brain tumor in adults. Despite the advances in its treatment, its prognosis remains very poor. Gene therapy has been proposed as a complementary treatment since i
Autor:
Juan Iturrizaga, Irene Angélica Keitelman, Fernando D. Gómez, David Antonio Rosso, Nazareno González, Carolina Maiumi Shiromizu, Alejandra T. Rabadán, Micaela Rosato, Gabriela Salamone, Carolina Jancic, Juan Valentin Coronel, María Marta Amaral
Publikováno v:
Journal of Neuro-Oncology. 153:403-415
γδ T lymphocytes are non-conventional T cells that participate in protective immunity and tumor surveillance. In healthy humans, the main subset of circulating γδ T cells express the TCRVγ9Vδ2. This subset responds to non-peptide prenyl-pyropho
Autor:
Miguel A. Pavón, Sonia Zumalave, Myriam Cuadrado, Antonio Abad, Carmen Segrelles, Xosé R. Bustelo, Gloria Pascual, Natalia Fernández-Parejo, María C. García-Macías, Salvador Aznar Benitah, Rogelio González-Sarmiento, Salvatore Fabbiano, Juan P. Rodrigo, Sonia Rodríguez-Fdez, Nazareno González, Mauricio Menacho-Márquez, L. Francisco Lorenzo-Martín, Javier Robles-Valero, Juana M. García-Pedrero, Pablo Lorenzano-Menna, Jesús M. Paramio, Jose M. C. Tubio
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Dipòsit Digital de la UB
Universidad de Barcelona
Digital.CSIC. Repositorio Institucional del CSIC
Nature Communications
RUO: Repositorio Institucional de la Universidad de Oviedo
Universidad de Oviedo (UNIOVI)
Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Dipòsit Digital de la UB
Universidad de Barcelona
Digital.CSIC. Repositorio Institucional del CSIC
Nature Communications
RUO: Repositorio Institucional de la Universidad de Oviedo
Universidad de Oviedo (UNIOVI)
© The Author(s) 2020.
Regenerative proliferation capacity and poor differentiation are histological features usually linked to poor prognosis in head and neck squamous cell carcinoma (hnSCC). However, the pathways that regulate them remain ill-
Regenerative proliferation capacity and poor differentiation are histological features usually linked to poor prognosis in head and neck squamous cell carcinoma (hnSCC). However, the pathways that regulate them remain ill-
Autor:
Hugo A. Garro, Fiamma A. Buratti, Christian Griesinger, Carla F. Ramunno, Claudio O. Fernández, Nazareno González, Iñaki Gentile, Susana Delgado-Ocaña
Publikováno v:
Journal of Biological Inorganic Chemistry
The discovery of aggregation inhibitors and the elucidation of their mechanism of action are key in the quest to mitigate the toxic consequences of amyloid formation. We have previously characterized the antiamyloidogenic mechanism of action of sodiu
Autor:
David A, Rosso, Micaela, Rosato, Juan, Iturrizaga, Nazareno, González, Carolina M, Shiromizu, Irene A, Keitelman, Juan V, Coronel, Fernando D, Gómez, María M, Amaral, Alejandra T, Rabadan, Gabriela V, Salamone, Carolina C, Jancic
Publikováno v:
Journal of neuro-oncology. 153(3)
γδ T lymphocytes are non-conventional T cells that participate in protective immunity and tumor surveillance. In healthy humans, the main subset of circulating γδ T cells express the TCRVγ9Vδ2. This subset responds to non-peptide prenyl-pyropho
Autor:
Antonela Sofía Asad, Adriana Seilicovich, Alejandro Javier Nicola Candia, Marianela Candolfi, Nazareno González, Camila Florencia Zuccato
Publikováno v:
Expert opinion on therapeutic targets. 24(11)
Introduction: Prolactin (PRL) and its receptor (PRLR) have been associated with the development of hormone-dependent tumors and have been detected in glioblastoma (GBM) biopsies. GBM is the most common and aggressive primary brain tumor in adults and
Autor:
Nazareno González, Georgina A. Cardama, Patricio Chinestrad, Javier Robles-Valero, Sonia Rodríguez-Fdez, L. Francisco Lorenzo-Martín, Xosé R. Bustelo, Pablo Lorenzano Menna, Daniel E. Gomez
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
instname
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
instname
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
In the last years, the development of new drugs in oncology has evolved notably. In particular, drug development has shifted from empirical screening of active cytotoxic compounds to molecularly targeted drugs blocking specific biologic pathways that
Publikováno v:
Medicina (Buenos Aires), Vol 77, Iss 6, Pp 497-504 (2017)
Rho GTPases are molecular switches that control the different cellular processes. Deregulation of these proteins is associated to transformation and malignant progression in several cancer types. Given the evidence available of the role of Rho GTPase