Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Nazar Trotsko"'
Autor:
Lidia Węglińska, Adrian Bekier, Nazar Trotsko, Barbara Kaproń, Tomasz Plech, Katarzyna Dzitko, Agata Paneth
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2621-2634 (2022)
A safer treatment for toxoplasmosis would be achieved by improving the selectivity profile of novel chemotherapeutics compared to the standard therapy pyrimethamine (PYR) and sulfadiazine (SDZ). We previously reported on the identification of the com
Externí odkaz:
https://doaj.org/article/79d58e45c8734949b193085685825372
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17521 (2023)
The number of people affected by cancer and antibiotic-resistant bacterial infections has increased, such that both diseases are already seen as current and future leading causes of death globally. To address this issue, based on a combined in silico
Externí odkaz:
https://doaj.org/article/b5361b31f67646ae881e1f40686da6b7
Autor:
Nazar Trotsko
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 325 (2023)
Thiazolidin-4-ones have a broad range of medical and clinical implementation, which is important for pharmaceutical and medicinal chemistry. This heterocyclic core has been reported to possess a diversity of bioactivities, including antimicrobial and
Externí odkaz:
https://doaj.org/article/f195ada075784ab39e59811ba287a872
Autor:
Katarzyna Dzitko, Barbara Kaproń, Agata Paneth, Adrian Bekier, Tomasz Plech, Piotr Paneth, Nazar Trotsko
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2069 (2023)
Two distinct intracellular pathogens, namely Mycobacterium tuberculosis (Mtb) and Toxoplasma gondii (Tg), cause major public health problems worldwide. In addition, serious and challenging health problems of co-infections of Tg with Mtb have been rec
Externí odkaz:
https://doaj.org/article/0e7149ec297147a2ba204552ac8e7e75
Publikováno v:
Molecules, Vol 27, Iss 12, p 3750 (2022)
The rhodanine core is a well-known privileged heterocycle in medicinal chemistry. The rhodanines, as subtypes of thiazolidin-4-ones, show a broad spectrum of biological activity, including anticancer properties. This review aims to analyze the antica
Externí odkaz:
https://doaj.org/article/3a7f30a0bd284d2f845f67f19b432e33
Publikováno v:
Molbank, Vol 2020, Iss 3, p M1150 (2020)
The new methyl [3-(4-chlorophenyl)-2-{[(2,4-dichloro-1,3-thiazol-5-yl)methylidene]hydrazinylidene}-4-oxo-1,3-thiazolidin-5-ylidene]acetate was synthesized from 4-(4-chlorophenyl)-1-(2,4-dichloro-1,3-thiazol-5-yl)methylidene-3-thiosemicarbazide using
Externí odkaz:
https://doaj.org/article/302bfa0a9091463498c973fe218ba9ed
Publikováno v:
Saudi Pharmaceutical Journal, Vol 26, Iss 4, Pp 568-577 (2018)
A series of new (2,4-dioxothiazolidin-5-yl/ylidene)acetic acid derivatives with thiazolidine-2,4-dione, rhodanine and 2-thiohydantoin moiety (28–65) were synthesized by the reaction of (2,4-dioxothiazolidin-5-yl/ylidene)acetic acid chlorides with 5
Externí odkaz:
https://doaj.org/article/e1d5c79143e144d1bb04b3d5645dfc80
Autor:
Nazar Trotsko, Agata Przekora, Justyna Zalewska, Grażyna Ginalska, Agata Paneth, Monika Wujec
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 17-24 (2018)
In our present research, we synthesised new thiazolidine-2,4-diones (12–28). All the newly synthesised compounds were evaluated for antiproliferative and antibacterial activity. Antiproliferative evaluation was carried out using normal human skin f
Externí odkaz:
https://doaj.org/article/da7a4e8d1fbb4168867a0ee7cf3df5cc
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11533 (2021)
Thiazolidin-4-ones is an important heterocyclic ring system of a pharmacophore and a privileged scaffold in medicinal chemistry. This review is focused on the latest scientific reports regarding biological activities of thiazolidin-4-ones published i
Externí odkaz:
https://doaj.org/article/a6995943bf8f46cea6b9557cba82c1ca
Publikováno v:
Molecules, Vol 26, Iss 1, p 170 (2020)
The development of drug-resistant bacteria is currently one of the major challenges in medicine. Therefore, the discovery of novel lead structures for the design of antibacterial drugs is urgently needed. In this structure–activity relationship stu
Externí odkaz:
https://doaj.org/article/36dfccf9825b4719b71fd97daf03f927