Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nazanin, Mohammadzadeh"'
Publikováno v:
Viruses, Vol 15, Iss 12, p 2385 (2023)
There is currently no cure for HIV infection although adherence to effective antiretroviral therapy (ART) suppresses replication of the virus in blood, increases CD4+ T-cell counts, reverses immunodeficiency, and increases life expectancy. Despite th
Externí odkaz:
https://doaj.org/article/0d400edbe6874ca98436208d337c488b
Autor:
Nazanin Mohammadzadeh, Na Zhang, William G. Branton, Ouafa Zghidi-Abouzid, Eric A. Cohen, Benjamin B. Gelman, Jerome Estaquier, Linglong Kong, Christopher Power
Publikováno v:
Viruses, Vol 15, Iss 2, p 316 (2023)
HIV-encoded DNA, RNA and proteins persist in the brain despite effective antiretroviral therapy (ART), with undetectable plasma and cerebrospinal fluid viral RNA levels, often in association with neurocognitive impairments. Although the determinants
Externí odkaz:
https://doaj.org/article/a39154ea0d0941cc93f86f5fa0cc9abb
Autor:
Hanjing Yang, Fumiaki Ito, Aaron D. Wolfe, Shuxing Li, Nazanin Mohammadzadeh, Robin P. Love, Maocai Yan, Brett Zirkle, Amit Gaba, Linda Chelico, Xiaojiang S. Chen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
APOBEC3G (A3G) belongs to the DNA/RNA cytosine deaminase family that plays important roles in innate immunity against HIV and internal retroelements. Here the authors report the structures of two full-length A3G variants that provides insight into do
Externí odkaz:
https://doaj.org/article/81810bdeadd84813b61a8392fef16fb6
Autor:
Nazanin Mohammadzadeh, Weston Roda, William G. Branton, Julien Clain, Henintsoa Rabezanahary, Ouafa Zghidi-Abouzid, Benjamin B. Gelman, Jonathan B. Angel, Eric A. Cohen, M. John Gill, Michael Li, Jérome Estaquier, Christopher Power
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT HIV infection persists in different tissue reservoirs among people with HIV (PWH) despite effective antiretroviral therapy (ART). In the brain, lentiviruses replicate principally in microglia and trafficking macrophages. The impact of ART on
Externí odkaz:
https://doaj.org/article/0b9a4f4e27ba432fbba6fde7bb9db8d2
Autor:
Fareeda M. Barzak, Timothy M. Ryan, Nazanin Mohammadzadeh, Stefan Harjes, Maksim V. Kvach, Harikrishnan M. Kurup, Kurt L. Krause, Linda Chelico, Vyacheslav V. Filichev, Elena Harjes, Geoffrey B. Jameson
Publikováno v:
Viruses, Vol 14, Iss 9, p 1974 (2022)
APOBEC3 enzymes are polynucleotide deaminases, converting cytosine to uracil on single-stranded DNA (ssDNA) and RNA as part of the innate immune response against viruses and retrotransposons. APOBEC3G is a two-domain protein that restricts HIV. Altho
Externí odkaz:
https://doaj.org/article/e6bb7a035b1541ab907a372338d6e150
Autor:
William G, Branton, Jason P, Fernandes, Nazanin, Mohammadzadeh, Mathew A L, Doan, Jon D, Laman, Benjamin B, Gelman, Zahra, Fagrouch, Ivanela, Kondova, Petra, Mooij, Gerrit, Koopman, Christopher, Power
Publikováno v:
Brain, Behavior, and Immunity, 107, 110-123. ACADEMIC PRESS INC ELSEVIER SCIENCE
Background: Systemic inflammation accompanies HIV-1 infection, resulting in microbial translocation from different tissues. We investigated interactions between lentivirus infections, neuroinflammation and microbial molecule presence in the brain. Me
Autor:
Nazanin Mohammadzadeh, Robin P. Love, Richard Gibson, Eric J. Arts, Art F.Y. Poon, Linda Chelico
Publikováno v:
Heliyon, Vol 5, Iss 4, Pp e01498- (2019)
The APOBEC3 enzymes can induce mutagenesis of HIV-1 proviral DNA through the deamination of cytosine. HIV-1 overcomes this restriction through the viral protein Vif that induces APOBEC3 proteasomal degradation. Within this dynamic host-pathogen relat
Externí odkaz:
https://doaj.org/article/f9efa491831749fb83244e02b671ce2d
Autor:
Madison B. Adolph, Robin P. Love, Nazanin Mohammadzadeh, Linda Chelico, Louis M. Mansky, Yumeng Z McDaniel, Dake Wang
Publikováno v:
Nucleic Acids Research
The human apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3 (APOBEC3, A3) family member proteins can deaminate cytosines in single-strand (ss) DNA, which restricts human immunodeficiency virus type 1 (HIV-1), retrotransposons, and ot
Autor:
Linda Chelico, Brett Zirkle, Shu-Xing Li, Robin P. Love, Fumiaki Ito, Amit Gaba, Hanjing Yang, Maocai Yan, Aaron Wolfe, Xiaojiang S. Chen, Nazanin Mohammadzadeh
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
APOBEC3G, a member of the double-domain cytidine deaminase (CD) APOBEC, binds RNA to package into virions and restrict HIV-1 through deamination-dependent or deamination-independent inhibition. Mainly due to lack of a full-length double-domain APOBEC
Autor:
Nazanin Mohammadzadeh, Robin P. Love, Tyson B. Follack, Linda Chelico, Stephen E. Sanche, Kris Stewart
Publikováno v:
Virology. 527:21-31
The APOBEC3 enzyme family are host restriction factors that induce mutagenesis of HIV-1 proviral genomes through the deamination of cytosine to form uracil in nascent single-stranded (-)DNA. HIV-1 suppresses APOBEC3 activity through the HIV-1 protein