Clinical outcomes and immune responses to SARS-CoV-2 vaccination in severe aplastic anaemia

Autor: Roma V. Rajput, Xiaoyang Ma, Kristin L. Boswell, Martin Gaudinski, Ingelise Gordon, Laura Novik, Emma M. Groarke, Jennifer Lotter, Jeanine Superata, Olga J. Rios, Ivana Darden, Bob C. Lin, Nazaire Jean‐Baptiste, Robin Carroll, Christopher Moore, Jessica Trost, Mursal Naisan, Jacquelyn Willis, Leonid Serebryannyy, Jennifer L. Wang, Madhu Prabhakaran, Sandeep R. Narpala, Richard A. Koup, Adrian McDermott, Colin O. Wu, Neal S. Young, Bhavisha A. Patel

Publikováno v: British journal of haematologyREFERENCES. 199(5)

Patients with severe aplastic anaemia (SAA) are often not vaccinated against viruses due to concerns of ineffective protective antibody response and potential for pathogenic global immune system activation, leading to relapse. We evaluated the impact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::065711de7e52f71a976eb84df782d572
https://pubmed.ncbi.nlm.nih.gov/36128909

mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits similar B cell expansion, neutralizing responses, and protection from Omicron

Autor: Matthew Gagne, Juan I. Moliva, Kathryn E. Foulds, Shayne F. Andrew, Barbara J. Flynn, Anne P. Werner, Danielle A. Wagner, I-Ting Teng, Bob C. Lin, Christopher Moore, Nazaire Jean-Baptiste, Robin Carroll, Stephanie L. Foster, Mit Patel, Madison Ellis, Venkata-Viswanadh Edara, Nahara Vargas Maldonado, Mahnaz Minai, Lauren McCormick, Christopher Cole Honeycutt, Bianca M. Nagata, Kevin W. Bock, Caitlyn N.M. Dulan, Jamilet Cordon, Dillon R. Flebbe, John-Paul M. Todd, Elizabeth McCarthy, Laurent Pessaint, Alex Van Ry, Brandon Narvaez, Daniel Valentin, Anthony Cook, Alan Dodson, Katelyn Steingrebe, Saule T. Nurmukhambetova, Sucheta Godbole, Amy R. Henry, Farida Laboune, Jesmine Roberts-Torres, Cynthia G. Lorang, Shivani Amin, Jessica Trost, Mursal Naisan, Manjula Basappa, Jacquelyn Willis, Lingshu Wang, Wei Shi, Nicole A. Doria-Rose, Yi Zhang, Eun Sung Yang, Kwanyee Leung, Sijy O’Dell, Stephen D. Schmidt, Adam S. Olia, Cuiping Liu, Darcy R. Harris, Gwo-Yu Chuang, Guillaume Stewart-Jones, Isabella Renzi, Yen-Ting Lai, Agata Malinowski, Kai Wu, John R. Mascola, Andrea Carfi, Peter D. Kwong, Darin K. Edwards, Mark G. Lewis, Hanne Andersen, Kizzmekia S. Corbett, Martha C. Nason, Adrian B. McDermott, Mehul S. Suthar, Ian N. Moore, Mario Roederer, Nancy J. Sullivan, Daniel C. Douek, Robert A. Seder

Publikováno v: Cell. 185:1556-1571.e18

SARS-CoV-2 Omicron is highly transmissible and has substantial resistance to neutralization following immunization with ancestral spike-matched vaccines. It is unclear whether boosting with Omicron-matched vaccines would enhance protection. Here, non

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b66941abd2f84105e968afdfeb4097
https://doi.org/10.1016/j.cell.2022.03.038