Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Naz, Chaudary"'
Autor:
Jelena Lukovic, Kathy Han, Melania Pintilie, Naz Chaudary, Richard P. Hill, Anthony Fyles, Michael Milosevic
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 19, Iss , Pp 110-115 (2019)
Background and Purpose: Gene expression signatures are often used to identify hypoxic tumors. However, intratumoral heterogeneity raises concern that multiple biopsies may be necessary to assess global hypoxia status. The objective of this study was
Externí odkaz:
https://doaj.org/article/8f6a5f2dfa5d4950815c82b8a6003a99
Autor:
Rachel Glicksman, Naz Chaudary, Melania Pintilie, Eric Leung, Blaise Clarke, Kieyan Sy, Richard P. Hill, Kathy Han, Anthony Fyles, Michael Milosevic
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 6, Iss C, Pp 15-20 (2017)
Background and purpose: Hypoxia, high interstitial fluid pressure (IFP) and immune effects have individually been shown to modulate radiotherapy (RT) response in cervical cancer. The aim of this study was to investigate the interplay between hypoxia
Externí odkaz:
https://doaj.org/article/3f04aae6cfde49c8a3dc7729793ff68f
Autor:
Eric Leung, Rob A. Cairns, Naz Chaudary, Ravi N. Vellanki, Tuula Kalliomaki, Eduardo H. Moriyama, Hilda Mujcic, Brian C. Wilson, Bradly G. Wouters, Richard Hill, Michael Milosevic
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-12 (2017)
Abstract Background A high rate of glycolysis leading to elevated lactate content has been linked to poor clinical outcomes in patients with head and neck and cervical cancer treated with radiotherapy. Although the biological explanation for this rel
Externí odkaz:
https://doaj.org/article/8d12ffffb4a64c1cae6e5f000b00a6cb
Autor:
Marianne Koritzinsky, Michael Milosevic, Marjan Rouzbahman, Ur Metser, David Jaffray, Sara Pakbaz, Douglass Vines, Rob Cairns, Melania Pintilie, Jeffrey Bruce, Naz Chaudary, Ting-Yim Lee, David D'Souza, Neesha Dhani, Jennifer Croke, Tina Shek, Anthony Fyles, Kathy Han
Supplementary Data from A Phase II Randomized Trial of Chemoradiation with or without Metformin in Locally Advanced Cervical Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbf14a1d8e035450a00bef2a788559f1
https://doi.org/10.1158/1078-0432.22488981
https://doi.org/10.1158/1078-0432.22488981
Autor:
Marianne Koritzinsky, Michael Milosevic, Marjan Rouzbahman, Ur Metser, David Jaffray, Sara Pakbaz, Douglass Vines, Rob Cairns, Melania Pintilie, Jeffrey Bruce, Naz Chaudary, Ting-Yim Lee, David D'Souza, Neesha Dhani, Jennifer Croke, Tina Shek, Anthony Fyles, Kathy Han
Purpose:Tumor hypoxia is associated with poor response to radiation (RT). We previously discovered a novel mechanism of metformin: enhancing tumor RT response by decreasing tumor hypoxia. We hypothesized that metformin would decrease tumor hypoxia an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::277b5ebc89e7e3e2f3b7e21eefa4ad66
https://doi.org/10.1158/1078-0432.c.6532854
https://doi.org/10.1158/1078-0432.c.6532854
Autor:
Michael Milosevic, Richard P. Hill, Patricia Lindsay, Salomeh Jelveh, Melania Pintilie, Naz Chaudary
Tumor growth delay summary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3836e66a5ca1c3be745637613e189b4c
https://doi.org/10.1158/1078-0432.22466373
https://doi.org/10.1158/1078-0432.22466373
Autor:
Bradly G. Wouters, Marianne Koritzinsky, Richard P. Hill, Jenna Sykes, Michael Milosevic, Blaise Clarke, Paul N. Span, Naz Chaudary, Stephen Chung, Kasper M.A. Rouschop, Anika Nagelkerke, Hilda Mujcic
Supplementary Data - PDF file 113K, This file contains supplementary materials and methods, and the legends of the 14 supplementary figures. Suppl. Table 1 shows the patients characteristic from the clinical study described in main Fig 1. Suppl. Tabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::292741852510029e9058f4846de30958
https://doi.org/10.1158/1078-0432.22450563.v1
https://doi.org/10.1158/1078-0432.22450563.v1
Autor:
Bradly G. Wouters, Marianne Koritzinsky, Richard P. Hill, Jenna Sykes, Michael Milosevic, Blaise Clarke, Paul N. Span, Naz Chaudary, Stephen Chung, Kasper M.A. Rouschop, Anika Nagelkerke, Hilda Mujcic
Purpose: Conditions of poor oxygenation (hypoxia) are present in many human tumors, including cervix cancer, and are associated with increased risk of metastasis and poor prognosis. Hypoxia is a potent activator of the PERK/eIF2α signaling pathway,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bc4d0710b2fc3060d11d7b6a04224a7
https://doi.org/10.1158/1078-0432.c.6521964.v1
https://doi.org/10.1158/1078-0432.c.6521964.v1
Autor:
Bradly G. Wouters, Marianne Koritzinsky, Richard P. Hill, Jenna Sykes, Michael Milosevic, Blaise Clarke, Paul N. Span, Naz Chaudary, Stephen Chung, Kasper M.A. Rouschop, Anika Nagelkerke, Hilda Mujcic
Supplementary Tables and Figures - PDF file 274K, 34-C orthotopic xenografts; Supplementary figure 10: Microvessel density and hVEGF expression in shLAMP3 orthotopic xenografts; Supplementary figure 11: Hypoxic fraction shLAMP3 orthotopic xenografts;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a15ed34b276d3848dda3af6e3ad2f9f
https://doi.org/10.1158/1078-0432.22450560
https://doi.org/10.1158/1078-0432.22450560
Autor:
Michael Milosevic, Richard P. Hill, Patricia Lindsay, Salomeh Jelveh, Melania Pintilie, Naz Chaudary
Purpose: There is an important need to improve the effectiveness of radio-chemotherapy (RTCT) for cervical cancer. The CXCL12/CXCR4 pathway can influence RT response by recruiting normal myeloid cells to the tumor microenvironment that in turn can ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab6fb23f0143e63ee326acd4e23431a
https://doi.org/10.1158/1078-0432.c.6526302
https://doi.org/10.1158/1078-0432.c.6526302