Microbial intestinal dysbiosis drives long-term allergic susceptibility by sculpting an ILC2-B1 cell-innate IgE axis.

Autor: Kabil A; School of Biomedical Engineering, University of British Columbia, Vancouver, British Columbia, Canada., Nayyar N; School of Biomedical Engineering, University of British Columbia, Vancouver, British Columbia, Canada., Brassard J; School of Biomedical Engineering, University of British Columbia, Vancouver, British Columbia, Canada., Li Y; School of Biomedical Engineering, University of British Columbia, Vancouver, British Columbia, Canada., Chopra S; School of Biomedical Engineering, University of British Columbia, Vancouver, British Columbia, Canada., Hughes MR; School of Biomedical Engineering, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: mhughes@brc.ubc.ca., McNagny KM; School of Biomedical Engineering, University of British Columbia, Vancouver, British Columbia, Canada; Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada; Center for Heart Lung Innovation, St Paul's Hospital, Vancouver, British Columbia, Canada. Electronic address: kelly@brc.ubc.ca.

Publikováno v: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2024 Nov; Vol. 154 (5), pp. 1260-1276.e9. Date of Electronic Publication: 2024 Aug 10.

Rapid tumor DNA analysis of cerebrospinal fluid accelerates treatment of central nervous system lymphoma.

Autor: Gupta M; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA.; Department of Neurosurgery, University of California San Diego, La Jolla, CA., Bradley JD; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA., Massaad E; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA., Burns EJ; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA., Georgantas NZ; Department of Pathology, Massachusetts General Hospital, Boston, MA., Maron GE; Department of Pathology, Massachusetts General Hospital, Boston, MA., Batten JM; Department of Pathology, Massachusetts General Hospital, Boston, MA., Gallagher A; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA., Thierauf J; Department of Pathology, Massachusetts General Hospital, Boston, MA.; Department of Otorhinolaryngology, Head and Neck Surgery, Experimental Head and Neck Oncology, Heidelberg University Hospital, Heidelberg, Germany., Nayyar N; Cancer Center, Massachusetts General Hospital, Boston, MA., Gordon A; Division of Neuro-Oncology, Department of Neurology, Massachusetts General Hospital Cancer Center, Boston, MA., Jones SS; Division of Neuro-Oncology, Department of Neurology, Massachusetts General Hospital Cancer Center, Boston, MA., Pisapia M; Division of Neuro-Oncology, Department of Neurology, Massachusetts General Hospital Cancer Center, Boston, MA., Sun Y; Division of Neuro-Oncology, Department of Neurology, Massachusetts General Hospital Cancer Center, Boston, MA., Jones PS; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA., Barker FG 2nd; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA., Curry WT; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA., Gupta R; Department of Neuroradiology, Massachusetts General Hospital, Boston, MA., Romero JM; Department of Neuroradiology, Massachusetts General Hospital, Boston, MA., Wang N; Department of Medicine, Massachusetts General Hospital, Boston, MA., Brastianos PK; Cancer Center, Massachusetts General Hospital, Boston, MA.; Department of Neurology, Massachusetts General Hospital, Boston, MA.; Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA., Martinez-Lage M; C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Boston, MA., Tateishi K; Department of Neurosurgery, Yokohama City University, Yokohama, Japan., Forst DA; Cancer Center, Massachusetts General Hospital, Boston, MA., Nahed BV; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA., Batchelor TT; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.; Department of Neurology, Brigham and Women's Hospital, Boston, MA., Ritterhouse LL; Department of Pathology, Massachusetts General Hospital, Boston, MA., Iser F; Department of Neurology and Neuro-Oncology Program, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany., Kessler T; Department of Neurology and Neuro-Oncology Program, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany., Jordan JT; Division of Neuro-Oncology, Department of Neurology, Massachusetts General Hospital Cancer Center, Boston, MA., Dietrich J; Cancer Center, Massachusetts General Hospital, Boston, MA.; Division of Neuro-Oncology, Department of Neurology, Massachusetts General Hospital Cancer Center, Boston, MA., Meyerson M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Cahill DP; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA., Lennerz JK; Department of Pathology, Massachusetts General Hospital, Boston, MA., Carter BS; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA., Shankar GM; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA.

Publikováno v: Blood [Blood] 2024 Sep 05; Vol. 144 (10), pp. 1093-1100.

Dynamical Mean-Field Theory for Molecules and Nanostructures

Autor: Turkowski, V., Kabir, A., Nayyar, N., Rahman, Talat S.

Dynamical Mean-Field Theory (DMFT) has established itself as a reliable and well-controlled approximation to study correlation effects in bulk solids and also two-dimensional systems. In combination with standard density-functional theory (DFT) it ha

Externí odkaz: http://arxiv.org/abs/1109.0893

CDK4/6 Inhibition Sensitizes Intracranial Tumors to PD-1 Blockade in Preclinical Models of Brain Metastasis.

Autor: Nayyar N; Program in Molecular Medicine, UMass Chan Medical School, Worcester, Massachusetts.; Center for Cancer Research, Massachusetts General Hospital, Boston, Massachusetts., de Sauvage MA; Center for Cancer Research, Massachusetts General Hospital, Boston, Massachusetts., Chuprin J; Program in Molecular Medicine, UMass Chan Medical School, Worcester, Massachusetts., Sullivan EM; Center for Cancer Research, Massachusetts General Hospital, Boston, Massachusetts., Singh M; Center for Cancer Research, Massachusetts General Hospital, Boston, Massachusetts., Torrini C; Center for Cancer Research, Massachusetts General Hospital, Boston, Massachusetts., Zhang BS; Center for Cancer Research, Massachusetts General Hospital, Boston, Massachusetts., Bandyopadhyay S; Program in Molecular Medicine, UMass Chan Medical School, Worcester, Massachusetts.; Gene Therapy Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Daniels KA; Program in Molecular Medicine, UMass Chan Medical School, Worcester, Massachusetts., Alvarez-Breckenridge C; Center for Cancer Research, Massachusetts General Hospital, Boston, Massachusetts.; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas., Dahal A; Center for Cancer Research, Massachusetts General Hospital, Boston, Massachusetts., Brehm MA; Center for Cancer Research, Massachusetts General Hospital, Boston, Massachusetts., Brastianos PK; Center for Cancer Research, Massachusetts General Hospital, Boston, Massachusetts.; Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2024 Jan 17; Vol. 30 (2), pp. 420-435.

Association of MTHFR Polymorphisms With Leukoencephalopathy Risk in Patients With Primary CNS Lymphoma Treated With Methotrexate-Based Regimens.

Autor: Karschnia P; From the Division of Neuro-Oncology (P.K., P.K.B., S.F.W., A.G., S.J., M.P., N.N., S.R.P., J.D.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurosurgery (P.K., J.-C.T.), Ludwig-Maximilians-University Munich; German Cancer Consortium (DKTK) (P.K.), Partner Site Munich; Section for Neuro-Oncology (S.C.K.), Department of Neurology, University of Tuebingen, Germany; and Department of Neurology (T.T.B.), Brigham and Woman's Hospital, Harvard Medical School, Boston, MA. p.karschnia@med.uni-muenchen.de., Kurz SC; From the Division of Neuro-Oncology (P.K., P.K.B., S.F.W., A.G., S.J., M.P., N.N., S.R.P., J.D.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurosurgery (P.K., J.-C.T.), Ludwig-Maximilians-University Munich; German Cancer Consortium (DKTK) (P.K.), Partner Site Munich; Section for Neuro-Oncology (S.C.K.), Department of Neurology, University of Tuebingen, Germany; and Department of Neurology (T.T.B.), Brigham and Woman's Hospital, Harvard Medical School, Boston, MA., Brastianos PK; From the Division of Neuro-Oncology (P.K., P.K.B., S.F.W., A.G., S.J., M.P., N.N., S.R.P., J.D.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurosurgery (P.K., J.-C.T.), Ludwig-Maximilians-University Munich; German Cancer Consortium (DKTK) (P.K.), Partner Site Munich; Section for Neuro-Oncology (S.C.K.), Department of Neurology, University of Tuebingen, Germany; and Department of Neurology (T.T.B.), Brigham and Woman's Hospital, Harvard Medical School, Boston, MA., Winter SF; From the Division of Neuro-Oncology (P.K., P.K.B., S.F.W., A.G., S.J., M.P., N.N., S.R.P., J.D.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurosurgery (P.K., J.-C.T.), Ludwig-Maximilians-University Munich; German Cancer Consortium (DKTK) (P.K.), Partner Site Munich; Section for Neuro-Oncology (S.C.K.), Department of Neurology, University of Tuebingen, Germany; and Department of Neurology (T.T.B.), Brigham and Woman's Hospital, Harvard Medical School, Boston, MA., Gordon A; From the Division of Neuro-Oncology (P.K., P.K.B., S.F.W., A.G., S.J., M.P., N.N., S.R.P., J.D.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurosurgery (P.K., J.-C.T.), Ludwig-Maximilians-University Munich; German Cancer Consortium (DKTK) (P.K.), Partner Site Munich; Section for Neuro-Oncology (S.C.K.), Department of Neurology, University of Tuebingen, Germany; and Department of Neurology (T.T.B.), Brigham and Woman's Hospital, Harvard Medical School, Boston, MA., Jones S; From the Division of Neuro-Oncology (P.K., P.K.B., S.F.W., A.G., S.J., M.P., N.N., S.R.P., J.D.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurosurgery (P.K., J.-C.T.), Ludwig-Maximilians-University Munich; German Cancer Consortium (DKTK) (P.K.), Partner Site Munich; Section for Neuro-Oncology (S.C.K.), Department of Neurology, University of Tuebingen, Germany; and Department of Neurology (T.T.B.), Brigham and Woman's Hospital, Harvard Medical School, Boston, MA., Pisapia M; From the Division of Neuro-Oncology (P.K., P.K.B., S.F.W., A.G., S.J., M.P., N.N., S.R.P., J.D.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurosurgery (P.K., J.-C.T.), Ludwig-Maximilians-University Munich; German Cancer Consortium (DKTK) (P.K.), Partner Site Munich; Section for Neuro-Oncology (S.C.K.), Department of Neurology, University of Tuebingen, Germany; and Department of Neurology (T.T.B.), Brigham and Woman's Hospital, Harvard Medical School, Boston, MA., Nayyar N; From the Division of Neuro-Oncology (P.K., P.K.B., S.F.W., A.G., S.J., M.P., N.N., S.R.P., J.D.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurosurgery (P.K., J.-C.T.), Ludwig-Maximilians-University Munich; German Cancer Consortium (DKTK) (P.K.), Partner Site Munich; Section for Neuro-Oncology (S.C.K.), Department of Neurology, University of Tuebingen, Germany; and Department of Neurology (T.T.B.), Brigham and Woman's Hospital, Harvard Medical School, Boston, MA., Tonn JC; From the Division of Neuro-Oncology (P.K., P.K.B., S.F.W., A.G., S.J., M.P., N.N., S.R.P., J.D.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurosurgery (P.K., J.-C.T.), Ludwig-Maximilians-University Munich; German Cancer Consortium (DKTK) (P.K.), Partner Site Munich; Section for Neuro-Oncology (S.C.K.), Department of Neurology, University of Tuebingen, Germany; and Department of Neurology (T.T.B.), Brigham and Woman's Hospital, Harvard Medical School, Boston, MA., Batchelor TT; From the Division of Neuro-Oncology (P.K., P.K.B., S.F.W., A.G., S.J., M.P., N.N., S.R.P., J.D.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurosurgery (P.K., J.-C.T.), Ludwig-Maximilians-University Munich; German Cancer Consortium (DKTK) (P.K.), Partner Site Munich; Section for Neuro-Oncology (S.C.K.), Department of Neurology, University of Tuebingen, Germany; and Department of Neurology (T.T.B.), Brigham and Woman's Hospital, Harvard Medical School, Boston, MA., Plotkin SR; From the Division of Neuro-Oncology (P.K., P.K.B., S.F.W., A.G., S.J., M.P., N.N., S.R.P., J.D.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurosurgery (P.K., J.-C.T.), Ludwig-Maximilians-University Munich; German Cancer Consortium (DKTK) (P.K.), Partner Site Munich; Section for Neuro-Oncology (S.C.K.), Department of Neurology, University of Tuebingen, Germany; and Department of Neurology (T.T.B.), Brigham and Woman's Hospital, Harvard Medical School, Boston, MA., Dietrich J; From the Division of Neuro-Oncology (P.K., P.K.B., S.F.W., A.G., S.J., M.P., N.N., S.R.P., J.D.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; Department of Neurosurgery (P.K., J.-C.T.), Ludwig-Maximilians-University Munich; German Cancer Consortium (DKTK) (P.K.), Partner Site Munich; Section for Neuro-Oncology (S.C.K.), Department of Neurology, University of Tuebingen, Germany; and Department of Neurology (T.T.B.), Brigham and Woman's Hospital, Harvard Medical School, Boston, MA.

Publikováno v: Neurology [Neurology] 2023 Oct 24; Vol. 101 (17), pp. e1741-e1746. Date of Electronic Publication: 2023 Aug 01.