Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Nayra M Al-Thani"'
1
Akademický článek
Novel protein contact points among TP53 and minichromosome maintenance complex proteins 2, 3, and 5
Autor: Stephanie Schaefer‐Ramadan, Jovana Aleksic, Nayra M. Al‐Thani, Joel A. Malek
Publikováno v: Cancer Medicine, Vol 11, Iss 24, Pp 4989-5000 (2022)
Abstract Objective Identify protein contact points between TP53 and minichromosome maintenance (MCM) complex proteins 2, 3, and 5 with high resolution allowing for potential novel Cancer drug design. Methods A next‐generation sequencing‐based pro
Externí odkaz: https://doaj.org/article/69f95f3c68ac4658906a7c14111c84e8
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2
Akademický článek
Identifying novel interactions of the colon-cancer related APC protein with Wnt-pathway nuclear transcription factors
Autor: Nayra M. Al-Thani, Stephanie Schaefer-Ramadan, Jovana Aleksic, Yasmin A. Mohamoud, Joel A. Malek
Publikováno v: Cancer Cell International, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Background Colon cancer is often driven by mutations of the adenomatous polyposis coli (APC) gene, an essential tumor suppressor gene of the Wnt β-catenin signaling pathway. APC and its cytoplasmic interactions have been well studied. Howev
Externí odkaz: https://doaj.org/article/db27634126fd4368a237a3bbedfe4ccf
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3
Scaling-up a fragment-based protein-protein interaction method using a human reference interaction set
Autor: Joel A. Malek, Jovana Aleksic, Nayra M Al-Thani, Stephanie Schaefer-Ramadan, David E. Hill, Yasmin A. Mohamoud
Publikováno v: Proteins. 90(4)
Protein-protein interactions (PPIs) are essential in understanding numerous aspects of protein function. Here, we significantly scaled and modified analyses of the recently developed all-vs-all sequencing (AVA-Seq) approach using a gold-standard huma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be3ed517e197f2c0e9789339030cf16
https://pubmed.ncbi.nlm.nih.gov/34850971
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5
High-resolution protein–protein interaction mapping using all-versus-all sequencing (AVA-Seq)
Autor: Simeon S. Andrews, Ikhlak Ahmed, Stephanie Schaefer-Ramadan, Joel A. Malek, Yasmin A. Mohamoud, Nayra M Al-Thani
Publikováno v: Journal of Biological Chemistry. 294:11549-11558
Two-hybrid systems can be used for investigating protein-protein interactions and may provide important information about gene products with unknown function. Despite their success in mapping protein interactions, two-hybrid systems have remained mos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f69b2983b6679481246476e6e9af4f40
https://doi.org/10.1074/jbc.ra119.008792
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6
High-resolution protein fragment interactions using AVA-Seq on a human reference set
Autor: Nayra M Al-Thani, Yasmin A. Mohamoud, Jovana Aleksic, David E. Hill, Joel A. Malek, Stephanie Ramadan
Protein-protein interactions (PPIs) are important in understanding numerous aspects of protein function. Here, the recently developed all-vs-all sequencing (AVA-Seq) approach to determine protein-protein interactions was tested on a gold-standard hum
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f4d2d2899539f4223715ea0bd3173e6
https://doi.org/10.1101/2021.07.28.454266
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8
High resolution protein-protein interaction mapping using all-versus-all sequencing (AVA-seq)
Autor: Ikhlak Ahmed, Simeon S. Andrews, Stephanie Ramadan, Yasmin A. Mohamoud, Nayra M Al-Thani, Joel A. Malek
Two-hybrid systems test for protein-protein interactions and can provide important information for genes with unknown function. Despite their success, two-hybrid systems have remained mostly untouched by improvements from next-generation DNA sequenci
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ac2a5bc4501ad058752ee3c2d5e3b4
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