Zobrazeno 1 - 10 of 31 pro vyhledávání: '"Nayoung Ko"'
1
Akademický článek
A desirable transgenic strategy using GGTA1 endogenous promoter-mediated knock-in for xenotransplantation model
Autor: Nayoung Ko, Joohyun Shim, Hyoung-Joo Kim, Yongjin Lee, Jae-Kyung Park, Kyungmin Kwak, Jeong-Woong Lee, Dong-Il Jin, Hyunil Kim, Kimyung Choi
Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Pig-to-human organ transplantation is a feasible solution to resolve the shortage of organ donors for patients that wait for transplantation. To overcome immunological rejection, which is the main hurdle in pig-to-human xenotransplantation,
Externí odkaz: https://doaj.org/article/9af5897a9cd04f4cb6fd32739454dc65
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2
Akademický článek
Effect of Factor H on Complement Alternative Pathway Activation in Human Serum Remains on Porcine Cells Lacking N-Glycolylneuraminic Acid
Autor: Haneulnari Lee, Eun Mi Park, Nayoung Ko, Kimyung Choi, Keon Bong Oh, Hee Jung Kang
Publikováno v: Frontiers in Immunology, Vol 13 (2022)
BackgroundTriple knockout (TKO) donor pigs lacking alpha-1,3-galactose (Gal), N-glycolylneuraminic acid (Neu5Gc), and Sd(a) expressions were developed to improve the clinical success of xenotransplantation. Neu5Gc, a sialic acid expressed on cell sur
Externí odkaz: https://doaj.org/article/8899137a5bfc426e9cb9864aa6aea444
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3
Akademický článek
No excessive mutations in transcription activator-like effector nuclease-mediated α-1,3-galactosyltransferase knockout Yucatan miniature pigs
Autor: Kimyung Choi, Joohyun Shim, Nayoung Ko, Joonghoon Park
Publikováno v: Asian-Australasian Journal of Animal Sciences, Vol 33, Iss 2, Pp 360-372 (2020)
Objective Specific genomic sites can be recognized and permanently modified by genome editing. The discovery of endonucleases has advanced genome editing in pigs, attenuating xenograft rejection and cross-species disease transmission. However, off-ta
Externí odkaz: https://doaj.org/article/3636cf9c5c5b42829201df8a59d7874d
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6
Site-selective and metal-free C–H nitration of biologically relevant N-heterocycles
Autor: Min Seo Park, In Su Kim, Prithwish Ghosh, Nayoung Ko, Junghyea Moon, Harin Oh, Suho Kim, Neeraj Kumar Mishra, Hyun Ku Ji
Publikováno v: Archives of Pharmacal Research
Arch Pharm Res
The site-selective and metal-free C–H nitration reaction of quinoxalinones and pyrazinones as biologically important N-heterocycles with t-butyl nitrite is described. A wide range of quinoxalinones were efficiently applied in this transformation, p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f978be774bb65529a199aa3c6ce26ae
http://europepmc.org/articles/PMC8685193
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7
Ruthenium(II)-Catalyzed Tandem C-H Allylation and [3 + 2] Dipolar Cycloaddition to Construct Bridged Tetracycles
Autor: Junghyea Moon, Nayoung Ko, Seoeun Jang, Prithwish Ghosh, Hyung Sik Kim, Neeraj Kumar Mishra, In Su Kim
Publikováno v: Organic letters. 24(44)
The ruthenium(II)-catalyzed tandem C-H allylation and intramolecular dipolar cycloaddition between azomethine imines and 2-methylidenetrimethylene carbonate is described herein. The initially formed β-substituted allyl fragment could trigger the exo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df78accfac7193305929dde6dbcceebf
https://pubmed.ncbi.nlm.nih.gov/36315478
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8
Human immune reactivity of GGTA1/CMAH/A3GALT2 triple knockout Yucatan miniature pigs
Autor: Hyunil Kim, Jeong-Woong Lee, Nayoung Ko, Yongjin Lee, Kimyung Choi, Dong Il Jin, Joohyun Shim, Hyoung-Joo Kim
Publikováno v: Transgenic Research
In this study, we investigated the effect of a triple knockout of the genes alpha-1,3-galactosyltransferase (GGTA1), cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH), and alpha 1,3-galactosyltransferase 2 (A3GALT2) in Yucatan miniatu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4afb6cd7da58c4dd828c48180544b4b3
https://doi.org/10.1007/s11248-021-00271-w
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