Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Naylor-Olsen A"'
Akademický článek
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Autor:
Wenye Sun, Zhenmin He, Adel M. Naylor-Olsen, Deming Xu, Joseph P. Vacca, Leanne Bedard, Ashlee M. Earl, Christina Scherer, Abigail L. Manson, Maurice D. Lee, Diane M Rush, Mark E. Fitzgerald, Mingliang Zhang, Huisheng Xu, Michelle Palmer, Joshua A. Bittker, Michael Foley, Jean-Charles Marie, Jeremy R. Duvall, Giovanni Muncipinto
Publikováno v:
ACS Infectious Diseases. 3:349-359
In 2013, the Centers for Disease Control highlighted Clostridium difficile as an urgent threat for antibiotic-resistant infections, in part due to the emergence of highly virulent fluoroquinolone-resistant strains. Limited therapeutic options current
Autor:
Hartman, George D., Duggan, Mark E., Hoffman, William F., Meissner, Robert J., Perkins, James J., Zartman, Amy E., Naylor-Olsen, Adel M., Cook, Jacquelynn J., Glass, Joan D., Lynch, Robert J., Zhang, Guixiang, Gould, Robert J.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1999 9(6):863-868
Autor:
S. D. Lewis, Youwei Yan, Richard C.A. Isaacs, M. G. Solinsky, Lawrence Kuo, Julie A. Krueger, Bobby J. Lucas, Kellie J. Cutrona, Elizabeth A. Lyle, Adel M. Naylor-Olsen, Christina L. Newton, Daniel R. McMasters, J.J. Lynch
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2062-2066
Guided by X-ray crystallography of thrombin-inhibitor complexes and molecular modeling, alkylation of the N1 nitrogen of the imidazole P1 ligand of the pyridinoneacetamide thrombin inhibitor 1 with various acetamide moieties furnished inhibitors with
Akademický článek
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Autor:
Thomayant Prueksaritanont, Kara Merkle, John H. Hutchinson, Carmen Fernandez-Metzler, Mark E. Duggan, Audrey A. Wallace, Sevgi B. Rodan, Gary L. Stump, Hunt Cecilia, Michael J. Breslin, Adel M. Naylor-Olsen, Wasyl Halczenko, Chih-Tai Leu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1809-1812
Two novel series of small-molecule RGD mimetics containing either a substituted pyridone or pyrazinone central constraint were prepared. Modification of the β-alanine 3-substituent produced compounds that are potent and selective α v β 3 antagonis
Autor:
Dennis L. Bohn, Sanderson Philip E, Bobby J. Lucas, Adel M. Naylor-Olsen, Julie A. Krueger, Elizabeth A. Lyle, Franklin C. Clayton, Youwei Yan, S. Dale Lewis, Denise J. Bickel, Denice C. Welsh, Kellie J. Cutrona, Audrey A. Wallace, Kelly L. Savage
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1441-1444
We describe a series of highly potent and efficacious thrombin inhibitors based on a 3-amino-4-sulfonylpyridinone acetamide template. The functionally dense sulfonyl group stabilizes the aminopyridinone, conformationally constrains the 4-substituent,
Autor:
Adel M. Naylor-Olsen, Jacquelynn J. Cook, Robert J. Meissner, Amy E. Zartman, William F. Hoffman, Robert J. Gould, Guixiang Zhang, George D. Hartman, Joan D. Glass, R. J. Lynch, Mark E. Duggan, James J. Perkins
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:863-868
A new series of potent, linearly-minimized, orally active, selective GPIIb/IIIa inhibitors is identified. Thus 15 (L-750,034) achieves interaction via a constrained, non-turned conformation that maintains the proper distance between its charged termi
Autor:
Adel M. Naylor-Olsen, John T. Sisko, K.J. Stauffer, Elizabeth P. Baskin, Stephen F. Brady, C. M. Cooper, Maria T. Stranieri, Julie A. Krueger, K B Dancheck, Thomas J. Tucker, Elizabeth A. Lyle, J.J. Lynch, I.-W. Chen, Bobby J. Lucas, Jacquelynn J. Cook, William C. Lumma, S. D. Lewis, J. P. Vacca, Stephen J. Gardell, Marie A. Holahan, Youwei Yan
Publikováno v:
Journal of Medicinal Chemistry. 41:3210-3219
As part of an ongoing effort to prepare therapeutically useful orally active thrombin inhibitors, we have synthesized a series of compounds that utilize nonbasic groups in the P1 position. The work is based on our previously reported lead structure,
Autor:
Jules A. Shafer, Charles N. Habecker, Joseph P. Vacca, William M. Sanders, Thomas J. Tucker, Zhonguo Chen, A. M. Mulichak, S. Dale Lewis, Gerald S. Ponticello, Adel M. Naylor-Olsen, Brian T. Phillips
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:1697-1702
A novel, nonpeptidyl thrombin inhibitor, L-636,619 (1), was identified via topological similarity searching over the Merck Corporate Sample Database. X-ray crystallographic studies determined the geometry for ligand binding to the enzyme. Chemical mo