Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Nayana, Gaur"'
Autor:
Toomas Jagomäe, Nayana Gaur, Kadri Seppa, Riin Reimets, Marko Pastak, Mihkel Plaas, Allen Kaasik, Eero Vasar, Mario Plaas
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
AimWolfram Syndrome (WS) is a rare condition caused by mutations in Wfs1, with a poor prognosis and no cure. Mono-agonists targeting the incretin glucagon-like-peptide 1 (GLP-1) have demonstrated disease-modifying potential in pre-clinical and clinic
Externí odkaz:
https://doaj.org/article/837495d36ff5427582528fa2621ac92c
Autor:
Klara Metzner, Omar Darawsha, Mengzhe Wang, Nayana Gaur, Yiming Cheng, Annekathrin Rödiger, Christiane Frahm, Otto W. Witte, Fabiana Perocchi, Hubertus Axer, Julian Grosskreutz, Monika S. Brill
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Aging is a complex process characterized by several molecular and cellular imbalances. The composition and stability of the neuronal cytoskeleton is essential for the maintenance of homeostasis, especially in long neurites. Using human skin biopsies
Externí odkaz:
https://doaj.org/article/ec46b342acf04066b968bee81cb16163
Publikováno v:
Health and Quality of Life Outcomes, Vol 18, Iss 1, Pp 1-5 (2020)
Abstract Background Amyotrophic Lateral Sclerosis (ALS) is a rapidly progressive neurodegenerative disorder with limited robust disease-modifying therapies presently available. While several treatments are aimed at improving health-related quality of
Externí odkaz:
https://doaj.org/article/869a3792b6a14aae966611f5394dbeff
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
The pathogenesis of the fatal neurodegenerative condition amyotrophic lateral sclerosis (ALS) remains to be fully understood. Blood–brain barrier damage (BBBD) has been implicated as an exacerbating factor in several neurodegenerative conditions, i
Externí odkaz:
https://doaj.org/article/7fc5b1278b2e4d139b85e96845284bce
Autor:
Caroline Perner, Florian Perner, Nayana Gaur, Silke Zimmermann, Otto W. Witte, Florian H. Heidel, Julian Grosskreutz, Tino Prell
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-5 (2019)
Abstract Background Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by motor and non-motor symptoms. There is increasing evidence that PD pathology is accompanied by an inflammatory response. This is highly relevan
Externí odkaz:
https://doaj.org/article/1ae7a00bc0334c70909c356305537752
Autor:
Nayana Gaur, Elena Huss, Tino Prell, Robert Steinbach, Joel Guerra, Akash Srivastava, Otto W. Witte, Julian Grosskreutz
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Neuroinflammation significantly contributes to Amyotrophic Lateral Sclerosis (ALS) pathology. In lieu of this, reports of elevated chitinase levels in ALS are interesting, as they are established surrogate markers of a chronic inflammatory response.
Externí odkaz:
https://doaj.org/article/bebc19d3947c4cd2b053b4fd53fbe52e
Autor:
Marie Dreger, Robert Steinbach, Nayana Gaur, Klara Metzner, Beatrice Stubendorff, Otto W. Witte, Julian Grosskreutz
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive neurodegenerative disorder. As previous therapeutic trials in ALS have been severely hampered by patients’ heterogeneity, the identification of biomarkers that reliably reflect disea
Externí odkaz:
https://doaj.org/article/7f8e799b79004bcd90860578d5aaaacf
Autor:
Robert Steinbach, Tino Prell, Nayana Gaur, Annekathrin Roediger, Christian Gaser, Thomas E. Mayer, Otto W. Witte, Julian Grosskreutz
Publikováno v:
NeuroImage: Clinical, Vol 30, Iss , Pp 102674- (2021)
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease that is characterized by a high heterogeneity in patients’ disease course. Patients with bulbar onset of symptoms (b-ALS) have a poorer prognosis than patients with limb
Externí odkaz:
https://doaj.org/article/a223c9875fc649368f2b5f959f458e2b
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative condition, most widely characterized by the selective vulnerability of motor neurons and the poor life expectancy of afflicted patients. Limited disease-modifying therapies current
Externí odkaz:
https://doaj.org/article/62eac3ca642a41b0a59f37c1c0da7c03
Autor:
Robert Steinbach, Meerim Batyrbekova, Nayana Gaur, Annika Voss, Beatrice Stubendorff, Thomas E. Mayer, Christian Gaser, Otto W. Witte, Tino Prell, Julian Grosskreutz
Publikováno v:
NeuroImage: Clinical, Vol 25, Iss , Pp - (2020)
Therapeutic management and research in Amyotrophic Laterals Sclerosis (ALS) have been limited by the substantial heterogeneity in progression and anatomical spread that are endemic of the disease. Neuroimaging biomarkers represent powerful additions
Externí odkaz:
https://doaj.org/article/20bec150fb9b4644a7afec622e29bd01