Patient-derived organoid biobank identifies epigenetic dysregulation of intestinal epithelial MHC-I as a novel mechanism in severe Crohn's Disease.

Autor: Dennison TW; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK.; Milner Therapeutics Institute, University of Cambridge, Cambridge, UK., Edgar RD; European Bioinformatics Institute, Cambridge, Cambridgeshire, UK.; Ajmera Transplant Centre, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada., Payne F; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK., Nayak KM; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK., Ross ADB; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK.; University Department of Medical Genetics, University of Cambridge, Cambridge, UK., Cenier A; Department of Paediatrics, University of Cambridge, Cambridge, UK.; Technische Universität München, ZIEL - Institute for Food & Health, Freising, Germany., Glemas C; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals (CUH), Addenbrooke's, Cambridge, UK., Giachero F; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK.; Department of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals (CUH), Addenbrooke's, Cambridge, UK., Foster AR; Milner Therapeutics Institute, University of Cambridge, Cambridge, UK.; Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK., Harris R; Milner Therapeutics Institute, University of Cambridge, Cambridge, UK., Kraiczy J; Department of Paediatrics, University of Cambridge, Cambridge, UK., Salvestrini C; Department of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals (CUH), Addenbrooke's, Cambridge, UK., Stavrou G; Department of Paediatrics, University of Cambridge, Cambridge, UK., Torrente F; Department of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals (CUH), Addenbrooke's, Cambridge, UK., Brook K; Department of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals (CUH), Addenbrooke's, Cambridge, UK., Trayers C; Department of Paediatric and Perinatal Pathology, Cambridge University Hospitals (CUH), Addenbrooke's Hospital, Cambridge, UK., Elmentaite R; Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK., Youssef G; Milner Therapeutics Institute, University of Cambridge, Cambridge, UK., Tél B; Pediatric Center, MTA Center of Excellence, Semmelweis University, Budapest, Hungary., Winton DJ; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Cancer Research-UK Cambridge Institute, Li Ka Shing Centre, Robinson Way, Cambridge, UK., Skoufou-Papoutsaki N; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Cancer Research-UK Cambridge Institute, Li Ka Shing Centre, Robinson Way, Cambridge, UK., Adler S; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Cancer Research-UK Cambridge Institute, Li Ka Shing Centre, Robinson Way, Cambridge, UK., Bufler P; Department of Pediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Azabdaftari A; Department of Pediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health (BIH) at Charité-Universitätsmedizin Berlin, Berlin, Germany., Jenke A; Department of Neonatology and General Pediatrics, Children's Hospital Kassel, Kassel, Germany.; Clinical Molecular Genetics and Epigenetics, Centre for Biomedical Education and Research (ZBAF), HELIOS University Hospital Wuppertal, Witten/Herdecke University, Wuppertal, Germany., G N; Department of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals (CUH), Addenbrooke's, Cambridge, UK., Thomas N; Department of Paediatrics, University of Cambridge, Cambridge, UK., Miele E; Department of Translational Medical Science, Section of Pediatrics, University of Naples 'Federico II', Naples, Italy., Al-Mohammad A; Department of Paediatrics, University of Cambridge, Cambridge, UK., Guarda G; Faculty of Biomedical Sciences, Institute for Research in Biomedicine (IRB), Università della Svizzera italiana, Bellinzona, Switzerland., Kugathasan S; Department of Pediatrics, Emory University, Atlanta, GA, USA.; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA., Venkateswaran S; Department of Pediatrics, Emory University, Atlanta, GA, USA., Clatworthy MR; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK.; Cellular Genetics, Wellcome Sanger Institute, Hinxton, UK.; Cambridge Institute of Therapeutic Immunology and Infectious Diseases, University of Cambridge, Cambridge, UK., Castro-Dopico T; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK., Suchanek O; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK.; Cambridge Institute of Therapeutic Immunology and Infectious Diseases, University of Cambridge, Cambridge, UK., Strisciuglio C; Department of Woman, Child ad General and Specialistic Surgery, University of Campania ' Vanvitelli', Naples, Italy., Gasparetto M; Norfolk and Norwich University Hospital, Jenny Lind Children's Hospital, Norwich, UK., Lee S; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Milner Therapeutics Institute, University of Cambridge, Cambridge, UK., Xu X; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Milner Therapeutics Institute, University of Cambridge, Cambridge, UK., Bello E; Milner Therapeutics Institute, University of Cambridge, Cambridge, UK., Han N; Milner Therapeutics Institute, University of Cambridge, Cambridge, UK.; Cambridge Centre for AI in Medicine, Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, UK., Zerbino DR; European Bioinformatics Institute, Cambridge, Cambridgeshire, UK., Teichmann SA; Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK.; Cambridge Centre for AI in Medicine, Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, UK.; Dept Physics/Cavendish Laboratory, Theory of Condensed Matter, JJ Thomson Ave, Cambridge, UK., Nys J; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Heuschkel R; Department of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals (CUH), Addenbrooke's, Cambridge, UK., Perrone F; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK mz304@cam.ac.uk fp385@cam.ac.uk.; Department of Paediatrics, University of Cambridge, Cambridge, UK., Zilbauer M; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK mz304@cam.ac.uk fp385@cam.ac.uk.; Department of Paediatrics, University of Cambridge, Cambridge, UK.; Department of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals (CUH), Addenbrooke's, Cambridge, UK.

Publikováno v: Gut [Gut] 2024 Aug 08; Vol. 73 (9), pp. 1464-1477. Date of Electronic Publication: 2024 Aug 08.

An upstream protein-coding region in enteroviruses modulates virus infection in gut epithelial cells.

Autor: Lulla V; Division of Virology, Department of Pathology, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK. vl284@cam.ac.uk., Dinan AM; Division of Virology, Department of Pathology, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK., Hosmillo M; Division of Virology, Department of Pathology, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK., Chaudhry Y; Division of Virology, Department of Pathology, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK., Sherry L; School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK., Irigoyen N; Division of Virology, Department of Pathology, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK., Nayak KM; Department of Paediatrics, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK., Stonehouse NJ; School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK., Zilbauer M; Department of Paediatrics, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK., Goodfellow I; Division of Virology, Department of Pathology, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK., Firth AE; Division of Virology, Department of Pathology, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK. aef24@cam.ac.uk.

Publikováno v: Nature microbiology [Nat Microbiol] 2019 Feb; Vol. 4 (2), pp. 280-292. Date of Electronic Publication: 2018 Nov 26.

DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome.

Autor: Howell KJ; University Department of Paediatrics, University of Cambridge, UK; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Kraiczy J; University Department of Paediatrics, University of Cambridge, UK., Nayak KM; University Department of Paediatrics, University of Cambridge, UK., Gasparetto M; University Department of Paediatrics, University of Cambridge, UK; Department of Paediatric Gastroenterology, University of Cambridge and Addenbrooke's Hospital, Cambridge, UK., Ross A; University Department of Paediatrics, University of Cambridge, UK; Wellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK., Lee C; University Department of Paediatrics, University of Cambridge, UK; Department of Paediatric Gastroenterology, University of Cambridge and Addenbrooke's Hospital, Cambridge, UK., Mak TN; University Department of Paediatrics, University of Cambridge, UK., Koo BK; Wellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK., Kumar N; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Lawley T; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Sinha A; Institute of Clinical Molecular Biology (IKMB), Kiel University, Kiel, Germany., Rosenstiel P; Institute of Clinical Molecular Biology (IKMB), Kiel University, Kiel, Germany., Heuschkel R; Department of Paediatric Gastroenterology, University of Cambridge and Addenbrooke's Hospital, Cambridge, UK., Stegle O; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK. Electronic address: stegle@ebi.ac.uk., Zilbauer M; University Department of Paediatrics, University of Cambridge, UK; Department of Paediatric Gastroenterology, University of Cambridge and Addenbrooke's Hospital, Cambridge, UK; Wellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK. Electronic address: mz304@medschl.cam.ac.uk.

Publikováno v: Gastroenterology [Gastroenterology] 2018 Feb; Vol. 154 (3), pp. 585-598. Date of Electronic Publication: 2017 Oct 12.

Determining the intention to use app-based medicine service in an emerging economy.

Autor: Ahmed, Selim¹ (AUTHOR) selim.ahmed@business.wub.edu.bd, Alqasmi, Ibrahim² (AUTHOR), Ashrafi, Dewan Mehrab³ (AUTHOR), Choudhury, Musfiq Mannan⁴ (AUTHOR), Rahman, Muhammad Khalilur⁵ (AUTHOR), Mohiuddin, Muhammad⁶ (AUTHOR)

Publikováno v: International Journal of Healthcare Management. Aug2024, Vol. 17 Issue 3, p468-482. 15p.

Probing milk extracellular vesicles for intestinal delivery of RNA therapies.

Autor: Zhang, Yunyue¹ (AUTHOR), Belaid, Mona¹ (AUTHOR), Luo, Xiang¹ (AUTHOR), Daci, Armond² (AUTHOR), Limani, Rinë² (AUTHOR), Mantaj, Julia^1,3 (AUTHOR), Zilbauer, Matthias^4,5 (AUTHOR), Nayak, Komal^4,5 (AUTHOR), Vllasaliu, Driton¹ (AUTHOR) driton.vllasaliu@kcl.ac.uk

Publikováno v: Journal of Nanobiotechnology. 11/3/2023, Vol. 21 Issue 1, p1-15. 15p.