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Akademický článek

Npas4: a neuronal transcription factor with a key role in social and cognitive functions relevant to developmental disorders.

Autor: Laurence Coutellier, Simret Beraki, Pooneh Memar Ardestani, Nay Lui Saw, Mehrdad Shamloo

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e46604 (2012)

Npas4 is a transcription factor, which is highly expressed in the brain and regulates the formation and maintenance of inhibitory synapses in response to excitatory synaptic activity. A deregulation of the inhibitory-excitatory balance has been assoc

Externí odkaz: https://doaj.org/article/d7235d8168ca4fd9950d9e9a07f8539e

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Collagen VI Regulates Motor Circuit Plasticity and Motor Performance by Cannabinoid Modulation

Autor: Daniel D. Lam, Rhîannan H. Williams, Ernesto Lujan, Koji Tanabe, Georg Huber, Nay Lui Saw, Juliane Merl-Pham, Aaro V. Salminen, David Lohse, Sally Spendiff, Melanie J. Plastini, Michael Zech, Hanns Lochmüller, Arie Geerlof, Stefanie M. Hauck, Mehrdad Shamloo, Marius Wernig, Juliane Winkelmann

Publikováno v: J Neurosci
J. Neurosci. 42, 1557-1573 (2022)

Collagen VI is a key component of muscle basement membranes, and genetic variants can cause monogenic muscular dystrophies. Conversely, human genetic studies recently implicated collagen VI in central nervous system function, with variants causing th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03398743b7a65eb43491f5d4185ba043
https://doi.org/10.1523/jneurosci.0962-21.2021

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Autor: Gaku Ogawa, Mehrdad Shamloo, Ryan D. Leib, Nay Lui Saw, Andrew K. Evans, Kratika Singhal, Heui Hye Park

Publikováno v: Neurobiol Aging

The locus coeruleus (LC) provides the primary noradrenergic input to the forebrain and hippocampus, and may be vulnerable to degeneration and contribute to age-related cognitive decline and neuroinflammation. Additionally, inhibition of noradrenergic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6935267105872068e7350dd7dce82c9f
https://doi.org/10.1016/j.neurobiolaging.2021.06.012

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Exercise plasma boosts memory and dampens brain inflammation via clusterin

Publikováno v: Nature, vol 600, iss 7889
Cell Res

Physical exercise is generally beneficial to all aspects of human and animal health, slowing cognitive ageing and neurodegeneration1. The cognitive benefits of physical exercise are tied to an increased plasticity and reduced inflammation within the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8a10ac483eac607b958484791dcb68
https://escholarship.org/uc/item/5011j3gh