Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Nawwaf Kharma"'
Autor:
Ke’Koa CDH Wells, Nawwaf Kharma, Brandon B. Jaunky, Kaiyu Nie, Gabriel Aguiar-Tawil, Daniel Berry
Publikováno v:
HardwareX, Vol 18, Iss , Pp e00516- (2024)
Liquid handler systems can provide significant benefits to researchers by automating laboratory work, however, their unaffordable price provides a steep barrier to entry. Therefore, we provide the BioCloneBot, a versatile, low-cost, and open-source a
Externí odkaz:
https://doaj.org/article/d427e1715f404216aae32a0657ef7712
Autor:
Alen N. Davis, Kenza Samlali, Jay B. Kapadia, Jonathan Perreault, Steve C. C. Shih, Nawwaf Kharma
Publikováno v:
ACS Omega, Vol 6, Iss 35, Pp 22514-22524 (2021)
Externí odkaz:
https://doaj.org/article/59fd6f5515eb4d80bd41834b8e0a8bd9
Autor:
Aida Abu-Baker, Nawwaf Kharma, Jonathan Perreault, Alanna Grant, Masoud Shekarabi, Claudia Maios, Michele Dona, Christian Neri, Patrick A. Dion, Alex Parker, Luc Varin, Guy A. Rouleau
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 15, Iss , Pp 12-25 (2019)
Oculopharyngeal muscular dystrophy (OPMD) is caused by a small expansion of a short polyalanine (polyAla) tract in the poly(A)-binding protein nuclear 1 protein (PABPN1). Despite the monogenic nature of OPMD, no treatment is currently available. Here
Externí odkaz:
https://doaj.org/article/9fec723309d74c3dab214a09045e1b3d
Publikováno v:
Frontiers in Genetics, Vol 7 (2016)
Computational design of RNA sequences that fold into targeted secondary structures hasmany applications in biomedicine, nanotechnology and synthetic biology. An RNA molecule ismade of different types of secondary structure elements and an important R
Externí odkaz:
https://doaj.org/article/d27f446ddff045d8add1b82a1193725a
Publikováno v:
RNA. 29:764-776
The design of new RNA sequences that retain the function of a model RNA structure is a challenge in bioinformatics because of the structural complexity of these molecules. RNA can fold into its secondary and tertiary structures by forming stem–loop
Publikováno v:
RNA. 28:263-273
This paper presents a probe comprising a fluorophore and a quencher, enabling measurement of released product from self-cleaving hammerhead ribozyme, without labeled RNA molecules, regular sampling or use of polyacrylamide gels. The probe is made of
Autor:
Jay Bhakti Kapadia, Jonathan Perreault, Nawwaf Kharma, Kenza Samlali, Alen Nellikulam Davis, Steve C. C. Shih
Publikováno v:
ACS Omega
ACS Omega, Vol 6, Iss 35, Pp 22514-22524 (2021)
ACS Omega, Vol 6, Iss 35, Pp 22514-22524 (2021)
In this paper, we describe the design and performance of two digital microfluidics (DMF) chips capable of executing multiple ribozymatic reactions, with proper controls, in response to short single-stranded DNA inducers. Since the fluorescence output
String: a programming language for the evolution of ribozymes in a new computational protocell model
Publikováno v:
The 2022 Conference on Artificial Life.
Publikováno v:
IJCCI
Publikováno v:
BIBE
this paper describes, in brief, an evolutionary algorithm (EA) for the design of RNA-activated hammerhead ribozymes that selectively cleave a mutant transcript, while leaving the wild type transcript largely unaffected. We present experimental data t