Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Nawrat CC"'
Autor:
William Lewis, Christopher J. Moody, Christopher C. Nawrat, Daniele Giallombardo, Adam C. Nevin, Russell R. A. Kitson
A synthesis of the naturally occurring xanthone toxyloxanthone B is described, in which the key step is the regioselective addition of a methyl salicylate to a substituted benzyne, followed by cyclization of the intermediate aryl anion to form the xa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8701b6615cd5ec5fc8d3aee4461ffd4e
http://hdl.handle.net/10447/86223
http://hdl.handle.net/10447/86223
Autor:
Shurtleff VW; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Layton ME; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Parish CA; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Perkins JJ; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Schreier JD; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Wang Y; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Adam GC; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Alvarez N; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States., Bahmanjah S; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Bahnck-Teets CM; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Boyce CW; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Burlein C; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Cabalu TD; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Campbell BT; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Carroll SS; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Chang W; Merck & Co., Inc., Rahway, New Jersey 07065, United States., de Lera Ruiz M; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Dolgov E; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States., Fay JF; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Fox NG; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Goh SL; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Hartingh TJ; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Hurzy DM; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Kelly MJ 3rd; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Klein DJ; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Klingler FM; MSD (U.K.) Limited, London EC2M 6UR, U.K., Krishnamurthy H; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Kudalkar S; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Mayhood TW; Merck & Co., Inc., Rahway, New Jersey 07065, United States., McKenna PM; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Murray EM; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Nahas D; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Nawrat CC; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Park S; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States., Qian D; Viva Biotech Ltd., Shanghai 201318, China., Roecker AJ; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Sharma V; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States., Shipe WD; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Su J; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Taggart RV; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Truong Q; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Wu Y; Viva Biotech Ltd., Shanghai 201318, China., Zhou X; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Zhuang N; Viva Biotech Ltd., Shanghai 201318, China., Perlin DS; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States., Olsen DB; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Howe JA; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., McCauley JA; Merck & Co., Inc., West Point, Pennsylvania 19486, United States.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2024 Mar 14; Vol. 67 (5), pp. 3935-3958. Date of Electronic Publication: 2024 Feb 16.
Autor:
Patel NR; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Nawrat CC; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., McLaughlin M; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Xu Y; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Huffman MA; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Yang H; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Li H; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Whittaker AM; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Andreani T; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Lévesque F; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Fryszkowska A; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Brunskill A; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Tschaen DM; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Maloney KM; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
Publikováno v:
Organic letters [Org Lett] 2020 Jun 19; Vol. 22 (12), pp. 4659-4664. Date of Electronic Publication: 2020 Jun 09.
Autor:
Nawrat CC; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Whittaker AM; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Huffman MA; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., McLaughlin M; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Cohen RD; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Andreani T; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Ding B; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Li H; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Weisel M; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Tschaen DM; Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
Publikováno v:
Organic letters [Org Lett] 2020 Mar 20; Vol. 22 (6), pp. 2167-2172. Date of Electronic Publication: 2020 Feb 28.
Autor:
Huffman MA; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA. mark_huffman@merck.com anna.fryszkowska@merck.com., Fryszkowska A; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA. mark_huffman@merck.com anna.fryszkowska@merck.com., Alvizo O; Codexis, Inc., 200 Penobscot Drive, Redwood City, CA 94063, USA., Borra-Garske M; Codexis, Inc., 200 Penobscot Drive, Redwood City, CA 94063, USA., Campos KR; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Canada KA; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Devine PN; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Duan D; Codexis, Inc., 200 Penobscot Drive, Redwood City, CA 94063, USA., Forstater JH; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Grosser ST; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Halsey HM; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Hughes GJ; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Jo J; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Joyce LA; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Kolev JN; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Liang J; Codexis, Inc., 200 Penobscot Drive, Redwood City, CA 94063, USA., Maloney KM; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Mann BF; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Marshall NM; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., McLaughlin M; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Moore JC; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Murphy GS; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Nawrat CC; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Nazor J; Codexis, Inc., 200 Penobscot Drive, Redwood City, CA 94063, USA., Novick S; Codexis, Inc., 200 Penobscot Drive, Redwood City, CA 94063, USA., Patel NR; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Rodriguez-Granillo A; Computational and Structural Chemistry, Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ 07033, USA., Robaire SA; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Sherer EC; Computational and Structural Chemistry, Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ 07033, USA., Truppo MD; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Whittaker AM; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Verma D; Computational and Structural Chemistry, Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ 07033, USA., Xiao L; Computational and Structural Chemistry, Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ 07033, USA., Xu Y; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA., Yang H; Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA.
Publikováno v:
Science (New York, N.Y.) [Science] 2019 Dec 06; Vol. 366 (6470), pp. 1255-1259.
Autor:
Joyce LA; Department of Process Research & Development , Merck & Co., Inc. , Rahway , NJ 07065 , USA . Email: leo.joyce@merck.com ; Email: christopher.nawrat@merck.com., Nawrat CC; Department of Process Research & Development , Merck & Co., Inc. , Rahway , NJ 07065 , USA . Email: leo.joyce@merck.com ; Email: christopher.nawrat@merck.com., Sherer EC; Department of Modeling and Informatics , Merck & Co., Inc. , Rahway , NJ 07065 , USA., Biba M; Department of Process Research & Development , Merck & Co., Inc. , Rahway , NJ 07065 , USA . Email: leo.joyce@merck.com ; Email: christopher.nawrat@merck.com., Brunskill A; Department of Process Research & Development , Merck & Co., Inc. , Rahway , NJ 07065 , USA . Email: leo.joyce@merck.com ; Email: christopher.nawrat@merck.com., Martin GE; Department of Process Research & Development , Merck & Co., Inc. , Rahway , NJ 07065 , USA . Email: leo.joyce@merck.com ; Email: christopher.nawrat@merck.com., Cohen RD; Department of Process Research & Development , Merck & Co., Inc. , Rahway , NJ 07065 , USA . Email: leo.joyce@merck.com ; Email: christopher.nawrat@merck.com., Davies IW; Department of Process Research & Development , Merck & Co., Inc. , Rahway , NJ 07065 , USA . Email: leo.joyce@merck.com ; Email: christopher.nawrat@merck.com.
Publikováno v:
Chemical science [Chem Sci] 2017 Oct 30; Vol. 9 (2), pp. 415-424. Date of Electronic Publication: 2017 Oct 30 (Print Publication: 2018).
Publikováno v:
Journal of the American Chemical Society [J Am Chem Soc] 2016 Feb 10; Vol. 138 (5), pp. 1724. Date of Electronic Publication: 2016 Jan 28.
Autor:
Nawrat CC; Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States., Jamison CR; Department of Chemistry, University of California, Irvine, California 92697-2025, United States., Slutskyy Y; Department of Chemistry, University of California, Irvine, California 92697-2025, United States., MacMillan DWC; Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States., Overman LE; Department of Chemistry, University of California, Irvine, California 92697-2025, United States.
Publikováno v:
Journal of the American Chemical Society [J Am Chem Soc] 2015 Sep 09; Vol. 137 (35), pp. 11270-11273. Date of Electronic Publication: 2015 Aug 31.
Autor:
Nawrat CC; School of Chemistry, University of Nottingham, University Park Nottingham NG7 2RD (United Kingdom)., Moody CJ
Publikováno v:
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2014 Feb 17; Vol. 53 (8), pp. 2056-77. Date of Electronic Publication: 2014 Jan 20.