Výsledky vyhledávání - "Nawid Madjroh"

Probing the molecular basis for signal transduction through the Zinc-Activated Channel (ZAC)

Autor: Nawid Madjroh, Paul Davies, Eleni Mellou, Laura Æbelø, Pella Cecilia Söderhielm, Anders A. Jensen

Publikováno v: Madjroh, N, Mellou, E, Æbelø, L, Davies, P A, Söderhielm, P C & Jensen, A A 2021, ' Probing the molecular basis for signal transduction through the Zinc-Activated Channel (ZAC) ', Biochemical Pharmacology, vol. 193, 114781 . https://doi.org/10.1016/j.bcp.2021.114781

The molecular basis for the signal transduction through the classical Cys-loop receptors (CLRs) has been delineated in great detail. The Zinc-Activated Channel (ZAC) constitutes a so far poorly elucidated fifth branch of the CLR superfamily, and in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437283ef4fa7fa3a9c7224667326789c
https://pubmed.ncbi.nlm.nih.gov/34560053

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Delineation of the functional properties exhibited by the Zinc-Activated Channel (ZAC) and its high-frequency Thr(128)Ala variant (rs2257020) in Xenopus oocytes

Autor: Nawid Madjroh, Uffe Kristiansen, Pella Cecilia Söderhielm, Joshua L. Smalley, Anders A. Jensen, Paul Davies

Publikováno v: Pharmacol Res
Madjroh, N, Davies, P A, Smalley, J L, Kristiansen, U, Söderhielm, P C & Jensen, A A 2021, ' Delineation of the functional properties exhibited by the Zinc-Activated Channel (ZAC) and its high-frequency Thr 128 Ala variant (rs2257020) in Xenopus oocytes ', Pharmacological Research, vol. 169, 105653 . https://doi.org/10.1016/j.phrs.2021.105653

The signalling characteristics of the Zinc-Activated Channel (ZAC), a member of the Cys-loop receptor (CLR) superfamily, are presently poorly elucidated. The ZACN polymorphism c.454G>A encoding for the Thr128Ala variation in ZAC is found in extremely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::073a232df82964af2e1e7d718ac3b4ba
https://europepmc.org/articles/PMC8248299/

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Discovery and functional characterization of N-(thiazol-2-yl)-benzamide analogs as the first class of selective antagonists of the Zinc-Activated Channel (ZAC)

Autor: Paul Davies, Pella Cecilia Söderhielm, Nawid Madjroh, Anders A. Jensen, Eleni Mellou

Publikováno v: Madjroh, N, Mellou, E, Davies, P A, Söderhielm, P C & Jensen, A A 2021, ' Discovery and functional characterization of N-(thiazol-2-yl)-benzamide analogs as the first class of selective antagonists of the Zinc-Activated Channel (ZAC) ', Biochemical Pharmacology, vol. 193, 114782 . https://doi.org/10.1016/j.bcp.2021.114782

The Zinc-Activated Channel (ZAC) is an atypical member of the Cys-loop receptor (CLR) superfamily of pentameric ligand-gated ion channels, with its very different endogenous agonists and signalling properties. In this study, a compound library screen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfbd2788d48fe9f3f84be880970833af
https://doi.org/10.1016/j.bcp.2021.114782

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Delineation of the functional properties and the mechanism of action of AA29504, an allosteric agonist and positive allosteric modulator of GABA

Autor: Emma Rie Olander, Nawid Madjroh, Lennart Bunch, Pella Cecilia Söderhielm, Anders A. Jensen

Publikováno v: Biochemical pharmacology. 150

The retigabine analog 2-amino-4-[(2,4,6-trimethylbenzylamino)-phenyl]-carbamic acid ethyl ester (AA29504) is a positive allosteric modulator (PAM) of γ-aminobutyric acid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::745e750c1f3cdc3986daaab4501e615a
https://pubmed.ncbi.nlm.nih.gov/29454619

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Functional properties and mechanism of action of PPTQ, an allosteric agonist and low nanomolar positive allosteric modulator at GABA

Autor: Anders A. Jensen, Christoffer Bundgaard, Emma Rie Olander, Nawid Madjroh, Pella Cecilia Söderhielm

Publikováno v: Biochemical pharmacology. 147

The former sedative-hypnotic and recreational drug methaqualone (Quaalude) is a moderately potent, non-selective positive allosteric modulator (PAM) at GABAA receptors (GABAARs) (Hammer et al., 2015). In the present study, we have identified a novel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::805f98a7d009b08a9c659126a7d6fa65
https://pubmed.ncbi.nlm.nih.gov/29155148

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Pharmacological Characterization of the Zinc-Activated Channel: A Cys-Loop Receptor Gated by Zn2+, Cu2+ And Protons

Autor: Nawid Madjroh, Paul Davies, Anders A. Jensen

Publikováno v: Biophysical Journal. 116:396a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a28d009d809051aa37c06b9bffb523a
https://doi.org/10.1016/j.bpj.2018.11.2139

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