Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Nawar Malhis"'
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Information on protein sequence variability and conservation can be leveraged to identify functionally important regions. Here, the authors develop new conservation measures that exploit taxonomy distances and LIST, a tool for predicting deleteriousn
Externí odkaz:
https://doaj.org/article/19806ffe4cf2405a9013b781a10363c3
Autor:
Eric T. C. Wong, Victor So, Mike Guron, Erich R. Kuechler, Nawar Malhis, Jennifer M. Bui, Jörg Gsponer
Publikováno v:
Biomolecules, Vol 10, Iss 8, p 1097 (2020)
Because proteins are fundamental to most biological processes, many genetic diseases can be traced back to single nucleotide variants (SNVs) that cause changes in protein sequences. However, not all SNVs that result in amino acid substitutions cause
Externí odkaz:
https://doaj.org/article/03e28d23d1d147cc8183f705a6e9a3bc
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141603 (2015)
MotivationIntrinsically disordered regions of proteins play an essential role in the regulation of various biological processes. Key to their regulatory function is often the binding to globular protein domains via sequence elements known as molecula
Externí odkaz:
https://doaj.org/article/808215520d0e441f984a404cfeafc43a
Autor:
Yaoqi Zhou, Andrzej Kloczkowski, Johannes Söding, Milot Mirdita, Lukasz Kurgan, Zoran Obradovic, Martin Steinegger, Akila Katuwawala, A. Keith Dunker, Jörg Gsponer, Eshel Faraggi, Bi Zhao, Christopher J. Oldfield, Nawar Malhis
Publikováno v:
Nucleic Acids Research
We present DescribePROT, the database of predicted amino acid-level descriptors of structure and function of proteins. DescribePROT delivers a comprehensive collection of 13 complementary descriptors predicted using 10 popular and accurate algorithms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5532799427c4aea84e9ae9e5cf3d8db5
http://europepmc.org/articles/PMC7778963
http://europepmc.org/articles/PMC7778963
Publikováno v:
Nucleic Acids Research
The separation of deleterious from benign mutations remains a key challenge in the interpretation of genomic data. Computational methods used to sort mutations based on their potential deleteriousness rely largely on conservation measures derived fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d513824d25053a26eac9ffc335bb672
https://doi.org/10.1093/nar/gkaa288
https://doi.org/10.1093/nar/gkaa288
Autor:
Victor So, Jörg Gsponer, Nawar Malhis, Jennifer M. Bui, Erich R. Kuechler, Eric C. Wong, Mike Guron
Publikováno v:
Biomolecules, Vol 10, Iss 1097, p 1097 (2020)
Biomolecules
Volume 10
Issue 8
Biomolecules
Volume 10
Issue 8
Because proteins are fundamental to most biological processes, many genetic diseases can be traced back to single nucleotide variants (SNVs) that cause changes in protein sequences. However, not all SNVs that result in amino acid substitutions cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd2d75d4f692ab934097e6c166710df8
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 1
Volume 21
Issue 1
APETALA2/ETHYLENE RESPONSE FACTOR transcription factors (AP2/ERFs) play crucial roles in adaptation to stresses such as those caused by pathogens, wounding and cold. Although their name suggests a specific role in ethylene signalling, some ERF member
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f22b9155f0847725b5066b22d3b141a
https://pubmed.ncbi.nlm.nih.gov/31861935
https://pubmed.ncbi.nlm.nih.gov/31861935
Publikováno v:
Bioinformatics
Motivation: A plethora of alignment tools have been created that are designed to best fit different types of alignment conditions. While some of these are made for aligning Illumina Sequence Analyzer reads, none of these are fully utilizing its proba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f872f7b1790651c578e217f6db56c4f5
https://doi.org/10.1093/bioinformatics/btn565
https://doi.org/10.1093/bioinformatics/btn565
Publikováno v:
Journal of Information & Knowledge Management. :287-291
When Apriori was first introduced as an algorithm for discovering association rules in a database of market basket data, the problem of generating the candidate set of the large set was a bottleneck in Apriori's performance, both in space and computa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e14470ef921c8611f51241d4c9289a
https://doi.org/10.1142/s0219649205001249
https://doi.org/10.1142/s0219649205001249
Autor:
Steven J.M. Jones, Nawar Malhis
Publikováno v:
Bioinformatics (Oxford, England). 26(8)
Motivation: Detection of single nucleotide polymorphisms (SNPs) has been a major application in processing second generation sequencing (SGS) data. In principle, SNPs are called on single base differences between a reference genome and a sequence gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e8d28e6de4cb6ee85aa5ac33510a15f
https://pubmed.ncbi.nlm.nih.gov/20190250
https://pubmed.ncbi.nlm.nih.gov/20190250