Modified Fluoroquinolones as Antimicrobial Compounds Targeting Chlamydia trachomatis

Autor: Thi Huyen Vu, Erika Adhel, Katarina Vielfort, Ngûyet-Thanh Ha Duong, Guillaume Anquetin, Katy Jeannot, Philippe Verbeke, Sofia Hjalmar, Åsa Gylfe, Nawal Serradji

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 12, p 6741 (2022)

Chlamydia trachomatis causes the most common sexually transmitted bacterial infection and trachoma, an eye infection. Untreated infections can lead to sequelae, such as infertility and ectopic pregnancy in women and blindness. We previously enhanced

Externí odkaz: https://doaj.org/article/0e972b573ad74facba82d1589c1c2e3b

PMS1077 sensitizes TNF-α induced apoptosis in human prostate cancer cells by blocking NF-κB signaling pathway.

Autor: Jie Shi, Jing Chen, Nawal Serradji, Ximing Xu, Heng Zhou, Yinxing Ma, Zhihong Sun, Peng Jiang, Yuping Du, Jinbo Yang, Changzhi Dong, Qin Wang

Publikováno v: PLoS ONE, Vol 8, Iss 4, p e61132 (2013)

Our previous studies have demonstrated that PMS1077, a platelet-activating factor (PAF) antagonist, could induce apoptosis of Raji cells. However, the mechanism of action has not yet been determined. The nuclear transcription factor-kappa B (NF-κB)

Externí odkaz: https://doaj.org/article/306cbc1f5ff04cafa91aa34ffbe4b048

Inhibition of Chlamydia trachomatis Growth During the Last Decade: A Mini-Review

Autor: Jayanth Panyam, Philippe Verbeke, Thi Huyen Vu, Nawal Serradji, Hyunjoon Kim

Publikováno v: Mini-Reviews in Medicinal Chemistry. 18:1363-1372

Chlamydia trachomatis is responsible for the most frequent sexually transmitted bacterial infection in the world and for trachoma, the world's leading infectious cause of blindness. Genital chlamydial infection is very common among sexually active yo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7441734bc98587a245f4fd919b7fc924
https://doi.org/10.2174/1389557518666180423152613

In vitro activities of a new fluoroquinolone derivative highly active against Chlamydia trachomatis

Autor: Philippe Verbeke, Nguyêt-Thanh Ha-Duong, Alexandra Aubry, Patrick Plésiat, Nawal Serradji, Thi Huyen Vu, Estelle Capton, Pierre Fechter

Publikováno v: Bioorganic Chemistry
Bioorganic Chemistry, Elsevier, 2019, 83, pp.180-185. ⟨10.1016/j.bioorg.2018.10.033⟩

International audience; Chlamydia trachomatis is a bacterial human pathogen responsible for the development of trachoma, an infection leading to blindness, and is also the cause of the main bacterial sexually transmitted infection worldwide. We desig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f99af2e72e0698b94b18cba5a9408f
https://hal.sorbonne-universite.fr/hal-02305467

Design and synthesis of 3-isoxazolidone derivatives as new Chlamydia trachomatis inhibitors

Autor: S. Abdelsayed, Jun Hai, Miryana Hémadi, Philippe Verbeke, N. T. Ha Duong, J. M. El Hage Chahine, Nawal Serradji

Publikováno v: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2014, 24 (16), pp.3854-60. ⟨10.1016/j.bmcl.2014.06.056⟩

International audience; Chlamydia trachomatis (Ct) is a bacterial human pathogen responsible for the development of trachoma, the worldwide infection leading to blindness, and is also a major cause of sexually transmitted diseases. As iron is an esse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b5c1b83c98d7736cba245cf9e400898
https://doi.org/10.1016/j.bmcl.2014.06.056