Zobrazeno 1 - 10 of 32 pro vyhledávání: '"Nawal A. El-Koussi"'
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Akademický článek
Design and synthesis of new dihydropyrimidine/sulphonamide hybrids as promising anti-inflammatory agents via dual mPGES-1/5-LOX inhibition
Autor: Lamya H. Al-Wahaibi, Ali M. Elshamsy, Taha F. S. Ali, Bahaa G. M. Youssif, S. Bräse, Mohamed Abdel-Aziz, Nawal A. El-Koussi
Publikováno v: Frontiers in Chemistry, Vol 12 (2024)
A novel series of dihydropyrimidine/sulphonamide hybrids 3a–j with anti-inflammatory properties have been developed and tested as dual mPGES-1/5-LOX inhibitors. In vitro assay, results showed that compounds 3c, 3e, 3h, and 3j were the most effectiv
Externí odkaz: https://doaj.org/article/0ac04f65ef574dc18e937444ce77c50f
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New pyrimidine/thiazole hybrids endowed with analgesic, anti-inflammatory, and lower cardiotoxic activities: Design, synthesis, and COX-2/sEH dual inhibition
Autor: Salah A. Abdel‐Aziz, Ehab S. Taher, Ping Lan, Nawal A. El‐Koussi, Ola I. A. Salem, Hesham A. M. Gomaa, Bahaa G. M. Youssif
Publikováno v: Archiv der PharmazieREFERENCES. 355(7)
Some cyclooxygenase (COX)-2 selective medications were withdrawn from the market just a few years after their production due to cardiovascular side effects. In this study, a new series of pyrimidine/thiazole hybrids 7a-p was synthesized as selective
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7b6dec52cd18afc81123f907a514817
https://pubmed.ncbi.nlm.nih.gov/35429006
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Design, synthesis, and antibacterial evaluation of new quinoline-1,3,4-oxadiazole and quinoline-1,2,4-triazole hybrids as potential inhibitors of DNA gyrase and topoisomerase IV
Autor: Mamdouh F.A. Mohamed, Nawal A. El-Koussi, Ahmed S. Aboraia, Salah A. Abdel-Aziz, Heba A. Hofny, Hesham A.M. Gomaa, Bahaa G.M. Youssif
Publikováno v: Bioorganic Chemistry. 112:104920
DNA gyrase and topoisomerase IV (topo IV) inhibitors are among the most interesting antibacterial drug classes without antibacterial pipeline representative. Twenty-four new quinoline-1,3,4-oxadiazole and quinoline-1,2,4-triazole hybrids were develop
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4a03d446d736883f619debb1bc99c3a
https://doi.org/10.1016/j.bioorg.2021.104920
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Design, synthesis, and biological evaluation of new pyrimidine-5-carbonitrile derivatives bearing 1,3-thiazole moiety as novel anti-inflammatory EGFR inhibitors with cardiac safety profile
Autor: Ping Lan, Salah A. Abdel-Aziz, Gihan F. Asaad, Bahaa G.M. Youssif, Ehab S. Taher, Hesham A.M. Gomaa, Nawal A. El-Koussi
Publikováno v: Bioorganic Chemistry. 111:104890
A new series of pyrimidine-5-carbonitrile derivatives 8a-p carrying the 1,3-thiazole moiety has been designed and synthesized as novel anti-inflammatory EGFR inhibitors with cardiac and gastric safety profiles. 8a-p have been assessed for their inhib
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d392d3c553a717c5cd394fc86102b529
https://doi.org/10.1016/j.bioorg.2021.104890
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Cu (I) catalyzed alkyne-azide 1,3-dipolar cycloaddition (CuAAC): Synthesis of 17α-[1-(substituted phenyl)-1,2,3-triazol-4-yl]-19-nor-testosterone-17β-yl acetates targeting progestational and antipro-liferative activities
Autor: Nawal A. El-Koussi, Gehad A. Abdel Jaleel, Adel F. Youssef, Z.H. Mohamed, Samia A. Shouman, Nadia M. Mahfouz
Publikováno v: European Journal of Medicinal Chemistry. 97:75-82
The progestational potency and selectivity of synthetic steroidal agonists can be enhanced by even larger chemical moieties at 17α-position of the steroid backbones. Hereby a series 5a-c and 6a-c of novel 17α-[1-(substituted phenyl)-1,2,3-triazol-4
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b386f09ee865d0f9e396ee9de77c94
https://doi.org/10.1016/j.ejmech.2015.04.045
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ANALYSIS OF PARACETAMOL AND ASCORBIC ACID IN PHARMACEUTICAL BINARY MIXTURE
Autor: Marwa F. Bakr, Hanaa M. Abdel-Wadood, Nawal A. El-Koussi, Kamla M. Emara
Publikováno v: Bulletin of Pharmaceutical Sciences. Assiut. 32:339-347
Two simple and sensitive spectrophotometric methods were developed for the determination of paracetamol (I) and ascorbic acid (II) in pharmaceutical binary mixture. The first method depends on the use of the first-derivative spectrophotometric techni
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1412bb06b178051c97a5944686f0d8e5
https://doi.org/10.21608/bfsa.2009.63522
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DESIGN, SYNTHESIS AND MOLECULAR MODELING STUDY OF 1,2,4-TRIAZOLE CARBOHYDRAZIDE DERIVATIVES WITH POTENTIAL ANTIMICROBIAL AND ANTI-INFLAMMATORY ACTIVITIES
Autor: Nawal A. El-Koussi
Publikováno v: Bulletin of Pharmaceutical Sciences. Assiut. 32:225-240
The present investigation is concerned with the synthesis of1,2,4-triazole carbohydrazide derivatives (6a-l) with the objectiveof discovering novel and potent antimicrobial and antiinflammatoryagents.The chemical structures of the target compounds we
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96162cbf9ac3f6159ea9b58368356fcb
https://doi.org/10.21608/bfsa.2009.63361
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