Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Navtej Toor"'
Autor:
Timothy Wiryaman, Navtej Toor
Publikováno v:
IUCrJ, Vol 8, Iss 3, Pp 342-350 (2021)
Protein nanocompartments are widespread in bacteria and archaea, but their functions are not yet well understood. Here, the cryo-EM structure of a nanocompartment from the thermophilic bacterium Thermotoga maritima is reported at 2.0 Å resolution. T
Externí odkaz:
https://doaj.org/article/68b01f51cb61478aa1822ed1b4af453f
Autor:
Timothy Wiryaman, Navtej Toor
Publikováno v:
Journal of Structural Biology: X, Vol 6, Iss , Pp 100062- (2022)
Large capsid-like nanocompartments called encapsulins are common in bacteria and archaea and contain cargo proteins with diverse functions. Advances in cryo-electron microscopy have enabled structure determination of many encapsulins in recent years.
Externí odkaz:
https://doaj.org/article/46667ca4d642473aaa85499146024630
Autor:
Russell T. Chan, Jessica K. Peters, Aaron R. Robart, Timothy Wiryaman, Kanagalaghatta R. Rajashankar, Navtej Toor
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Group II introns are large, self-splicing RNAs that catalyze their own excision from pre-mRNA molecules. Here the authors determine the 3.7 Å crystal structure of the group II intron in the stage immediately before the second step of splicing and pr
Externí odkaz:
https://doaj.org/article/7c5644150b6e47eb8f1cee53b217aef7
Autor:
Daniel B. Haack, Navtej Toor
Publikováno v:
Molecular Cell. 83:332-334
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b03c891d07df64eb57a09cd39b30aa1
https://doi.org/10.1016/j.molcel.2022.12.027
https://doi.org/10.1016/j.molcel.2022.12.027
We have devised a single pot, low-cost method to modify RNA with sulfinate salts that can directly add almost any desired functional group to nucleobases under mild aqueous conditions. This chemistry modifies the Hoogsteen edge of RNA and DNA nucleob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ead6fc0f12fb28f71349cac8042d62ad
https://doi.org/10.1101/2021.10.19.465008
https://doi.org/10.1101/2021.10.19.465008
Publikováno v:
Methods Mol Biol
Methods in Molecular Biology ISBN: 9781071607152
Methods in Molecular Biology ISBN: 9781071607152
Selective 2'-hydroxyl acylation analyzed by primer extension (SHAPE) is a widely used technique for studying the structure and function of RNA molecules. It characterizes the flexibility of single nucleotides in the context of the local RNA structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0552e22460610c6a6bcc794852207f0e
https://europepmc.org/articles/PMC7510887/
https://europepmc.org/articles/PMC7510887/
Autor:
Navtej Toor, Daniel B. Haack
Publikováno v:
Wiley Interdiscip Rev RNA
Recent cryo-EM structures of a group II intron caught in the process of invading DNA have given new insight into the mechanisms of both splicing and retrotransposition. Conformational dynamics involving the branch-site helix domain VI are responsible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eac71e8173e3abd158848a5101fc8f2d
https://doi.org/10.1002/wrna.1589
https://doi.org/10.1002/wrna.1589
Publikováno v:
Chemical Reviews. 118:4156-4176
Nuclear pre-mRNA splicing and group II intron self-splicing both proceed by two-step transesterification reactions via a lariat intron intermediate. Recently determined cryo-electron microscopy (cryo-EM) structures of catalytically active spliceosome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4582ac092402c744c3c4424d4a85c6
https://doi.org/10.1021/acs.chemrev.7b00499
https://doi.org/10.1021/acs.chemrev.7b00499
Publikováno v:
Journal of Molecular Biology. 428:4882-4889
Large RNAs often utilize GNRA tetraloops as structural elements to stabilize the overall tertiary fold. These tetraloop–receptor (TR) interactions have a conserved geometry in which the tetraloop docks into the receptor at an angle of ~ 15° from t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95a1a331dec64e79e582d70e8fb65477
https://doi.org/10.1016/j.jmb.2016.10.015
https://doi.org/10.1016/j.jmb.2016.10.015
Autor:
Jessica K. Peters, Navtej Toor, Russell T. Chan, Kanagalaghatta R. Rajashankar, Aaron R. Robart, Timothy Wiryaman
Publikováno v:
Nature communications, vol 9, iss 1
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
The group II intron and the spliceosome share a common active site architecture and are thought to be evolutionarily related. Here we report the 3.7 Å crystal structure of a eukaryotic group II intron in the lariat-3′ exon form, immediately preced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1a8293c46e25cbd7d97f3e1fc435e9c
https://doi.org/10.1038/s41467-018-06678-0
https://doi.org/10.1038/s41467-018-06678-0