Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Navnit Hargovindas Shah"'
Autor:
Wantanee Phuapradit, Siva Ram Kiran Vaka, Navnit Hargovindas Shah, Waseem Malick, Dipen Desai, Sandhu Harpreet K, Hossein Zia
Publikováno v:
Journal of pharmaceutical sciences. 107(1)
The objective of the study was to select solid-state plasticizers for hot-melt extrusion (HME) process. The physical and mechanical properties of plasticizers, in selected binary (polymer:plasticizer) and ternary (active pharmaceutical ingredient:pol
Autor:
Navnit Hargovindas Shah, Raman Mahadevan Iyer, Harpreet K. Sandhu, Fumie Tanno, Ashish L. Sarode, Sakae Obara
Publikováno v:
Carbohydrate Polymers. 101:146-153
HPMCAS is a widely used polymer in the pharmaceutical industry as an excipient. In this work, the physicochemical stability of HPMCAS was investigated for hot melt extrusion (HME) application. The reduction in zero rate viscosity (η0) of the polymer
Publikováno v:
Molecular Pharmaceutics. 10:3665-3675
Hot melt extrudates (HMEs) of indomethacin (IND) with Eudragit EPO and Kollidon VA 64 and those of itraconazole (ITZ) with HPMCAS-LF and Kollidon VA 64 were manufactured using a Leistritz twin screw extruder. The milled HMEs were stored at controlled
Publikováno v:
Journal of Pharmaceutical Innovation. 8:163-174
Drug and polymer mixing status in amorphous solid dispersions, an important aspect with regard to the physical stability and in vivo performance of such systems, was evaluated in this report with two case studies. In the first case study, the mixing
Publikováno v:
International Journal of Pharmaceutics. 450:53-62
Microprecipitated bulk powder (MBP) is a novel solid dispersion technology to manufacture amorphous formulations of poorly soluble compounds that cannot be processed by spray drying or melt extrusion. An efficient high-throughput screening method has
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 74:352-361
The objective of this study was to investigate the properties of enteric matrix pellets that were prepared by hot-melt extrusion in a one-step, continuous process. Five polymers (Eudragit® L100-55, L100 and S100, Aqoat® grades LF and HF) were inves
Publikováno v:
Journal of Pharmaceutical Sciences. 97:2286-2298
The objectives of this study were to formulate and stabilize amorphous formulation of low T(g) drug (Indomethacin, INM) with selected polymers and compare these formulations based on solubility and dissolution rate studies. Eudragit EPO (EPO), Polyvi
Autor:
A. Waseem Malick, Navnit Hargovindas Shah, Shawn A. Kucera, Doreen Stimpel, James W. McGinity, Martin Howard Infeld
Publikováno v:
Pharmaceutical Development and Technology. 13:245-253
The objective of this study was to investigate the influence of various grades of fumed silicon dioxide on the drug release rate and physical aging of theophylline pellets coated with Eudragit RS 30 D and RL 30 D. Free films were assessed for both ph
Autor:
James W. McGinity, Martin Howard Infeld, C. Tessmann, A. Waseem Malick, Shawn A. Kucera, Navnit Hargovindas Shah
Publikováno v:
Journal of Drug Delivery Science and Technology. 18:343-349
The objective of this study was to investigate the influence of ethylcellulose (EC), a high glass transition temperature, non-enteric polymer, on the physical stability and drug release properties of theophylline from pellets coated with the poorly p
Autor:
Navnit Hargovindas Shah, A. Waseem Malick, James W. McGinity, Martin Howard Infeld, Sandra U. Schilling
Publikováno v:
Journal of Pharmacy and Pharmacology. 59:1493-1500
The use of solid-state plasticizers for the hot-melt extrusion of pharmaceutical dosage forms has been shown to be beneficial compared with liquid plasticizers. The purpose of this study was to determine the suitability of citric acid (CA) as a solid