Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Navneet K. Tyagi"'
Autor:
Scott T. Brady, Navneet K. Tyagi, Wayne A. Fenton, John D. Overton, Arthur L. Horwich, Francesc López-Giráldez, Wei Ming Ni, Maria Nagy, Yuyu Song
Publikováno v:
Proceedings of the National Academy of Sciences. 110:5428-5433
Mutant human Cu/Zn superoxide dismutase 1 (SOD1) is associated with motor neuron toxicity and death in an inherited form of amyotrophic lateral sclerosis (ALS; Lou Gehrig disease). One aspect of toxicity in motor neurons involves diminished fast axon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4b6cb7ffb6878ba89b28c9681a94b0
https://doi.org/10.1073/pnas.1303279110
https://doi.org/10.1073/pnas.1303279110
Autor:
Hermann J. Gruber, Navneet K. Tyagi, Theeraporn Puntheeranurak, Isabel Neundlinger, Azad Kumar, Mobeen Raja, Peter Hinterdorfer, Barbara Wimmer, Rolf K. H. Kinne
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1808(1):1-18
Proteins mediating the transport of solutes across the cell membrane control the intracellular conditions in which life can occur. Because of the particular arrangement of spanning a lipid bilayer and the many conformations required for their functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8faf89775660aeb161b103ac7ff37f2
Publikováno v:
Proceedings of the National Academy of Sciences. 106:20264-20269
The GroEL/GroES reaction cycle involves steps of ATP and polypeptide binding to an open GroEL ring before the GroES encapsulation step that triggers productive folding in a sequestered chamber. The physiological order of addition of ATP and nonnative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4c6e93b8a6acae355f3ccd49e10eac
https://doi.org/10.1073/pnas.0911556106
https://doi.org/10.1073/pnas.0911556106
Autor:
Dharmendra Pandey, Pankaj Goyal, Navneet K. Tyagi, Wolfgang Siess, Rolf K. H. Kinne, Azad Kumar
Publikováno v:
Biochemistry. 46:13616-13628
In order to gain a better understanding of the structure-function relation in hSGLT1, single Trp residues were introduced into a functional hSGLT1 mutant devoid of Trps at positions that previously had been postulated to be involved in sugar recognit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bedcfe174ad19c504ccd8adff993c0e
https://doi.org/10.1021/bi701193x
https://doi.org/10.1021/bi701193x
Autor:
Wolfgang Siess, Azad Kumar, Rolf K. H. Kinne, Dharmendra Pandey, Pankaj Goyal, Navneet K. Tyagi
Publikováno v:
Biochemistry. 44:15514-15524
Studies on the structure-function relationship of transporters require the availability of sufficient amounts of the protein in a functional state. In this paper, we report the functional expression, purification, and reconstitution of the human sodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e64b2e9b36891ca1a2c17e33b6248781
https://doi.org/10.1021/bi051377q
https://doi.org/10.1021/bi051377q
Publikováno v:
Journal of Biological Chemistry. 278:49154-49163
SGLT1 as a sodium/glucose cotransporter is strongly inhibited by phlorizin, a phloretin 2'-glucoside that has strong interactions with the C-terminal loop 13. We have examined phlorizin recognition by the protein by site-directed single Trp scanning
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a0eca14b081a38bff4cb5be5b140f2
https://doi.org/10.1074/jbc.m306881200
https://doi.org/10.1074/jbc.m306881200
Autor:
Kaya Bilguvar, Angeliki Louvi, Mehmet Bakırcıoğlu, Navneet K. Tyagi, Titus J. Boggon, Cigdem Ozkara, Michele H. Johnson, Ahmet Okay Caglayan, Arthur L. Horwich, Beyhan Tüysüz, Sreeganga S. Chandra, Richard P. Lifton, Ozdem Erturk, Shrikant Mane, Murat Karacorlu, Murat Gunel, Murim Choi, Alp Dinçer, Sakir Delil, Cengiz Yalcinkaya, Jacob F Baranoski
Ubiquitin C-terminal hydrolase-L1 (UCHL1), a neuron-specific de-ubiquitinating enzyme, is one of the most abundant proteins in the brain. We describe three siblings from a consanguineous union with a previously unreported early-onset progressive neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6eab6e601551bd6f6cc8abd4ba623a2
https://doi.org/10.1073/pnas.1222732110
https://doi.org/10.1073/pnas.1222732110
Publikováno v:
FEBS letters. 585(12)
Under “permissive” conditions at 25°C, the chaperonin substrate protein DM-MBP refolds 5–10 times more rapidly in the GroEL/GroES folding chamber than in free solution. This has been suggested to indicate that the chaperonin accelerates polype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d44d711539789832b6271f1178a178f
https://pubmed.ncbi.nlm.nih.gov/21609718
https://pubmed.ncbi.nlm.nih.gov/21609718
Publikováno v:
Biochimica et biophysica acta. 1774(8)
In order to obtain further information about the structure and function of human sodium/ d -glucose cotransporter 1 (hSGLT1), the recombinant protein was subjected, either after reconstitution into liposomes or in its free form, to proteolysis follow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33032a18e92ce6a2e5838f56ab2e2641
https://pubmed.ncbi.nlm.nih.gov/17588833
https://pubmed.ncbi.nlm.nih.gov/17588833
Publikováno v:
Biophysical chemistry. 127(1-2)
Recombinant purified human sodium/D-glucose cotransporter1 (hSGLT1) was reconstituted in a functional form into phospholipid vesicles and its conformational states in the absence and presence of ligands and inhibitors were probed by intrinsic tryptop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c38e2fa830c6346e203249d347cafb
https://pubmed.ncbi.nlm.nih.gov/17222499
https://pubmed.ncbi.nlm.nih.gov/17222499