Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Navneet Ammal Kaidery"'
Autor:
Priyanka Soni, Navneet Ammal Kaidery, Sudarshana M. Sharma, Irina Gazaryan, Sergey V. Nikulin, Dmitry M. Hushpulian, Bobby Thomas
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Neurodegenerative diseases represent a pressing global health challenge, and the identification of novel mechanisms underlying their pathogenesis is of utmost importance. Ferroptosis, a non-apoptotic form of regulated cell death characterized by iron
Externí odkaz:
https://doaj.org/article/f038aea9e6284c14be3570e61d8fc184
Autor:
Manuj Ahuja, Navneet Ammal Kaidery, Debashis Dutta, Otis C. Attucks, Eliot H. Kazakov, Irina Gazaryan, Mitsuyo Matsumoto, Kazuhiko Igarashi, Sudarshana M. Sharma, Bobby Thomas
Publikováno v:
Antioxidants, Vol 11, Iss 9, p 1780 (2022)
Parkinson’s disease (PD) is the second most common neurodegenerative movement disorder characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Although a complex interplay of multiple environmental and gen
Externí odkaz:
https://doaj.org/article/826cc5ab347d47988b76837e6681c0a4
Autor:
Dmitry M. Hushpulian, Navneet Ammal Kaidery, Manuj Ahuja, Andrey A. Poloznikov, Sudarshana M. Sharma, Irina G. Gazaryan, Bobby Thomas
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
The Keap1-Nrf2 signaling axis is a validated and promising target for cellular defense and survival pathways. This minireview discusses the potential off-target effects and their impact on future drug development originating from Keap1-targeting smal
Externí odkaz:
https://doaj.org/article/54d2b73ecbdc47da83d47b5c45340714
Autor:
Soumya Navneet, Jing Zhao, Jing Wang, Barbara Mysona, Shannon Barwick, Navneet Ammal Kaidery, Alan Saul, Ismail Kaddour-Djebbar, Wendy B. Bollag, Bobby Thomas, Kathryn E. Bollinger, Sylvia B. Smith
Publikováno v:
Redox Biology, Vol 24, Iss , Pp - (2019)
Hyperhomocysteinemia (Hhcy), or increased levels of the excitatory amino acid homocysteine (Hcy), is implicated in glaucoma, a disease characterized by increased oxidative stress and loss of retinal ganglion cells (RGCs). Whether Hhcy is causative or
Externí odkaz:
https://doaj.org/article/ff920b2cdd234131b9890e4056bde9b7
Publikováno v:
Antioxidants & Redox Signaling. 35:580-594
Significance: Advancements in and access to health care have led to unprecedented improvements in the quality of life and increased lifespan of human beings in the past century. However, aging is a...
Autor:
Mitsuyo Matsumoto, Dmitry M. Hushpulian, Manuj Ahuja, Otis C. Attucks, Young Hoon Ahn, Arsen Gaisin, Erin McDade, S. Sharma, Irina G. Gazaryan, Bobby Thomas, Kazuhiko Igarashi, Masayuki Yamamoto, Sergey Nikulin, Navneet Ammal Kaidery, Irina N. Gaisina, Andrey A. Poloznikov
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The Keap1-Nrf2 signaling pathway is a promising therapeutic target for Parkinson’s disease (PD). Canonical Nrf2 activators targeting Keap1 thiols are known to be preventive but never effectively cure chronic neurodegeneration because o
Publikováno v:
Antioxid Redox Signal
Significance: Advancements in and access to health care have led to unprecedented improvements in the quality of life and increased lifespan of human beings in the past century. However, aging is a significant risk factor for neurodegenerative diseas
Autor:
Julie Vignisse, Bobby Thomas, Natalia N. Starkova, Lucien Bettendorff, Meri Gerges, Flint Beal, Manuj Ahuja, Cliona Stack, Ceyhan Elipenahli, Irina G. Gazaryan, N. A. Smirnova, Magali Dumont, Anatoly A. Starkov, Gary E. Gibson, Shari Jainuddin, Victor Tapias, Sushama Wakade, Navneet Ammal Kaidery, Hui Xu, D. M. Hushpulian, Noel Y. Calingasan
Publikováno v:
Human Molecular Genetics. 27:2874-2892
Impaired glucose metabolism, decreased levels of thiamine and its phosphate esters, and reduced activity of thiamine-dependent enzymes, such as pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase and transketolase occur in Alzheimer’s disease
Autor:
Dmitry M. Hushpulian, Eliot H. Kazakov, Bobby Thomas, Irina N. Gaisina, Irina G. Gazaryan, Manuj Ahuja, Arsen Gaisin, Navneet Ammal Kaidery, Andrey A. Poloznikov, Gregory R. J. Thatcher
Publikováno v:
Neurochem Int
Aspirin is a desired leaving group in prodrugs aimed at treatment of neurodegeneration and other conditions. A library of aspirin derivatives of various scaffolds potentially activating Nrf2 has been tested in Neh2-luc reporter assay which screens fo
Publikováno v:
Mol Cell Neurosci
Search for a definitive cure for neurodegenerative disorders like Parkinson's disease (PD) has met with little success. Mitochondrial dysfunction and elevated oxidative stress precede characteristic loss of dopamine-producing neurons from the midbrai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5758c20ecdb85fa96fbb274c34f82f64
https://europepmc.org/articles/PMC6981291/
https://europepmc.org/articles/PMC6981291/