Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis

Autor: Ulrich Pfisterer, Viktor Petukhov, Samuel Demharter, Johanna Meichsner, Jonatan J. Thompson, Mykhailo Y. Batiuk, Andrea Asenjo-Martinez, Navneet A. Vasistha, Ashish Thakur, Jens Mikkelsen, Istvan Adorjan, Lars H. Pinborg, Tune H. Pers, Jakob von Engelhardt, Peter V. Kharchenko, Konstantin Khodosevich

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)

The pathophysiology of epilepsy is unclear. Here, the authors present single-nuclei transcriptomic profiling of human temporal lobe epilepsy from patients. They identified epilepsy-associated neuronal subtypes, and a panel of dysregulated genes, pred

Externí odkaz: https://doaj.org/article/3e192b5fa2834006a330d7be93363fc6

C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity

Autor: Bhuvaneish T. Selvaraj, Matthew R. Livesey, Chen Zhao, Jenna M. Gregory, Owain T. James, Elaine M. Cleary, Amit K. Chouhan, Angus B. Gane, Emma M. Perkins, Owen Dando, Simon G. Lillico, Youn-Bok Lee, Agnes L. Nishimura, Urjana Poreci, Sai Thankamony, Meryll Pray, Navneet A. Vasistha, Dario Magnani, Shyamanga Borooah, Karen Burr, David Story, Alexander McCampbell, Christopher E. Shaw, Peter C. Kind, Timothy J. Aitman, C. Bruce A. Whitelaw, Ian Wilmut, Colin Smith, Gareth B. Miles, Giles E. Hardingham, David J. A. Wyllie, Siddharthan Chandran

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

Repeat expansion mutation in C9ORF72 is the most common cause of familial ALS. Here, the authors generate motor neurons from cells of patients with C9ORF72 mutations, and characterize changes in gene expression in these motor neurons compared to gene

Externí odkaz: https://doaj.org/article/6a962a5b03a74471945829a86138ad2f

TDP-43 proteinopathy in oligodendrocytes revealed using an induced pluripotent stem cell model

Autor: S Chandran, Owain T. James, David J. A. Wyllie, Emma M. Perkins, Matthew R. Livesey, Chen Zhao, C Rosanne M Ausems, Jenna M. Gregory, Alessandra Cardinali, Bhuvaneish T. Selvaraj, Karen Burr, Dario Magnani, Samantha K. Barton, Giles E. Hardingham, Owen G. James, Nicholas M. Morton, Roderick N. Carter, Elaine M. Cleary, David Story, Navneet A. Vasistha

Publikováno v: Barton, S K, Magnani, D, James, O G, Livesey, M R, Selvaraj, B T, James, O T, Perkins, E M, Gregory, J M, Cleary, E, Ausems, C R M, Carter, R, Vasistha, N A, Zhao, C, Burr, K, Story, D, Cardinali, A, Morton, N M, Hardingham, G E, Wyllie, D J A & Chandran, S 2021, ' TDP-43 proteinopathy in oligodendrocytes revealed using an induced pluripotent stem cell model ', Brain Communications, vol. 3, no. 4, fcab255 . https://doi.org/10.1093/braincomms/fcab255

Oligodendrocytes are implicated in amyotrophic lateral sclerosis pathogenesis and display transactive response DNA-binding protein-43 (TDP-43) pathological inclusions. To investigate the cell autonomous consequences of TDP-43 mutations on human oligo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d6d6e844edbdfe4e1fb94d4ced1ab0
https://www.pure.ed.ac.uk/ws/files/260345909/fcab255.pdf

Development of the Entorhinal Cortex Occurs via Parallel Lamination During Neurogenesis

Autor: Stefan E. Seemann, Menno P. Witter, Poul Hyttel, Yuki Mori, Yong Liu, Tobias Bergmann, Maria Pihl, Preben D. Thomsen, Jan Gorodkin, Vanessa Jane Hall, Juan Miguel Peralvo Vidal, Navneet A. Vasistha, Konstantin Khodosevich

Publikováno v: Liu, Y, Bergmann, T, Mori, Y, Vidal, J M P, Pihl, M, Vasistha, N A, Thomsen, P D, Seemann, S E, Gorodkin, J, Hyttel, P, Khodosevich, K, Witter, M P & Hall, V J 2021, ' Development of the entorhinal cortex occurs via parallel lamination during neurogenesis ', Frontiers in Neuroanatomy, vol. 15, 663667 . https://doi.org/10.3389/fnana.2021.663667
Frontiers in Neuroanatomy, Vol 15 (2021)
Frontiers in Neuroanatomy

The entorhinal cortex (EC) is the spatial processing center of the brain and structurally is an interface between the three layered paleocortex and six layered neocortex, known as the periarchicortex. Limited studies indicate peculiarities in the for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d339d342f44c0769bbf42da6d4c7c44f
https://doi.org/10.3389/fnana.2021.663667

The impact of (ab)normal maternal environment on cortical development

Autor: Konstantin Khodosevich, Navneet A. Vasistha

Publikováno v: Vasistha, N A & Khodosevich, K 2021, ' The impact of (ab)normal maternal environment on cortical development ', Progress in Neurobiology, vol. 202, 102054 . https://doi.org/10.1016/j.pneurobio.2021.102054

The cortex in the mammalian brain is the most complex brain region that integrates sensory information and coordinates motor and cognitive processes. To perform such functions, the cortex contains multiple subtypes of neurons that are generated durin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f244b78de4ecc48b59537955a34d627
https://pubmed.ncbi.nlm.nih.gov/33905709