Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Navneet Jawanda"'
Publikováno v:
Virology. 513:1-10
Mice have multiple obstacles to HIV replication, including a block of unspliced and partially spliced viral mRNA nuclear export. In human, Rev binds to the Rev-response element and human (h) Crm1, facilitating nuclear export of RRE-containing viral R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::649e616a4f4b5cdeaf9925045ec41988
https://doi.org/10.1016/j.virol.2017.09.027
https://doi.org/10.1016/j.virol.2017.09.027
Autor:
Mark Krystal, Nannan Zhou, Robert A. Domaoal, Krasimir A. Spasov, Don T. Li, William L. Jorgensen, Ran N. Tao, Christopher G. Parker, Markus K. Dahlgren, Takuji Shoda, David Spiegel, Sangil Lee, Navneet Jawanda, Richard E. Sutton, Eugene F. Douglass, Karen S. Anderson
Publikováno v:
Chem. Sci.. 5:2311-2317
Here we report on the structure-based optimization of antibody-recruiting molecules targeting HIV gp120 (ARM-H). These studies have leveraged a combination of medicinal chemistry, biochemical and cellular assay analysis, and computation. Our findings
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c74e5c585190ea57655f76248ea0eb
https://doi.org/10.1039/c4sc00484a
https://doi.org/10.1039/c4sc00484a
Autor:
Vanessa Pirrone, Shendra R. Miller, Simon Cocklin, Sabine Baxter, Ferit Tuzer, Irwin Chaiken, Judith M. LaLonde, M. Umashankara, Jeffrey C. Klein, Navneet Jawanda, Fred C. Krebs, Arne Schön, Amos B. Smith, Joseph Sodroski, Ernesto Freire, Navid Madani, Hosahudya N. Gopi, Isaac Zentner
Publikováno v:
Journal of Medicinal Chemistry. 51:2638-2647
Structure-activity correlations were investigated for substituted peptide conjugates that function as dual receptor site antagonists of HIV-1 gp120. A series of peptide conjugates were constructed via click reaction of both aryl and alkyl acetylenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f3bd9ceed55edf3bccdc7ccc21887b3
https://doi.org/10.1021/jm070814r
https://doi.org/10.1021/jm070814r
Publikováno v:
Biochemistry. 47:368-377
Vibrio harveyi luciferase and flavin reductase FRP are, together, a two-component monooxygenase couple. The reduced flavin mononucleotide (FMNH2) generated by FRP must be supplied, through either free diffusion or direct transfer, to luciferase as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b59d412c88a543268de5f5fa77449d9
https://doi.org/10.1021/bi701392b
https://doi.org/10.1021/bi701392b
Autor:
Vanessa Pirrone, Sandya Ajith, Karyn McFadden, Sabine Baxter, Hosahudya N. Gopi, Simon Cocklin, Fred C. Krebs, Irwin Chaiken, Isaac Zentner, Ferit Tuzer, Navneet Jawanda
Publikováno v:
Journal of molecular recognition : JMR. 22(2)
In this work, we identified a high affinity and potency metallocene-containing triazole peptide conjugate that suppresses the interactions of HIV-1 envelope gp120 at both its CD4 and co-receptor binding sites. The ferrocene-peptide conjugate, HNG-156
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df1749d5d801312bef18e02a7ae591a
https://pubmed.ncbi.nlm.nih.gov/18498083
https://pubmed.ncbi.nlm.nih.gov/18498083
Autor:
Jerry O. Ebalunode, J. Ching Lee, James M. Briggs, Alexey V. Gribenko, Shiao-Chun Tu, Navneet Jawanda
Publikováno v:
Archives of biochemistry and biophysics. 472(1)
Our earlier studies have shown that the Vibrio harveyi flavin reductase FRP undergoes a monomer–dimer equilibrium, and luciferase forms a functional complex with the FRP monomer but not significantly with the dimer. This work is aimed at further in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e63de10c31bb47fc0b1af5bb945832
https://pubmed.ncbi.nlm.nih.gov/18294448
https://pubmed.ncbi.nlm.nih.gov/18294448
Autor:
Hosahudya Gopi, M. Umashankara, Vanessa Pirrone, Judith LaLonde, Navid Madani, Ferit Tuzer, Sabine Baxter, Isaac Zentner, Simon Cocklin, Navneet Jawanda, Shendra R. Miller, Arne Schön, Jeffrey C. Klein, Ernesto Freire, Fred C. Krebs, Amos B. Smith, Joseph Sodroski, Irwin Chaiken
Publikováno v:
Journal of Medicinal Chemistry; Apr2008, Vol. 51 Issue 9, p2638-2647, 10p