Výsledky vyhledávání - "Navneet Agnihotri"

Akademický článek

Clinical relevance of CERK and SPHK1 in breast cancer and their association with metastasis and drug resistance

Autor: Priyanka Bhadwal, Vinay Randhawa, Kim Vaiphei, Divya Dahiya, Navneet Agnihotri

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)

Abstract Despite numerous reports on the altered sphingolipids metabolism in human cancers, their clinical significance in breast cancer remains obscure. Previously, we identified the high levels of sphingolipids, ceramide phosphates and sphingosine

Externí odkaz: https://doaj.org/article/526917ba1a824d69bb7b3d08efc6c919

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Akademický článek

Piperlongumine, a piper alkaloid targets Ras/PI3K/Akt/mTOR signaling axis to inhibit tumor cell growth and proliferation in DMH/DSS induced experimental colon cancer

Autor: Sandeep Kumar, Navneet Agnihotri

Publikováno v: Biomedicine & Pharmacotherapy, Vol 109, Iss , Pp 1462-1477 (2019)

Colorectal cancer (CRC) is the most common carcinoma of the digestive tract. The slow growing nature of CRC offers a great opportunity for prevention strategies. The concept of chemoprevention of colorectal cancer using plant derived natural products

Externí odkaz: https://doaj.org/article/72e29c79d9a74cf3b5da508880f02a26

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Dietary n-3 and n-6 polyunsaturated fatty acids differentially modulate the adiponectin and leptinmediated major signaling pathways in visceral and subcutaneous white adipose tissue in high fat diet induced obesity in Wistar rats

Autor: Prerna Sharma, Chetna Bhandari, Navneet Agnihotri

Publikováno v: Nutrition Research. 110:74-86

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ff33ebeb995f9668644273e5577fe28
https://doi.org/10.1016/j.nutres.2022.12.004

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Akademický článek

Apoptosis mediated chemosensitization of tumor cells to 5-fluorouracil on supplementation of fish oil in experimental colon carcinoma

Autor: Isha Rani, Bhoomika Sharma, Sandeep Kumar, Satinder Kaur, Navneet Agnihotri

Publikováno v: Tumor Biology, Vol 39 (2017)

5-Fluorouracil has been considered as a cornerstone therapy for colorectal cancer; however, it suffers from low therapeutic response rate and severe side effects. Therefore, there is an urgent need to increase the clinical efficacy of 5-fluorouracil.

Externí odkaz: https://doaj.org/article/912a4f99b0da42f58568afc12f7fcb6c

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Piperlongumine targets NF-κB and its downstream signaling pathways to suppress tumor growth and metastatic potential in experimental colon cancer

Autor: Sandeep Kumar, Navneet Agnihotri

Publikováno v: Molecular and Cellular Biochemistry. 476:1765-1781

NF-κB is the principle transcription factor and plays the central role in orchestrating chronic inflammation by regulating levels of cytokines, chemokines and growth factors. Piperlongumine (PL), a major alkaloid in the fruit of Piper longum Linn. h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61fe5bb5c72b0d2763542f0f689032df
https://doi.org/10.1007/s11010-020-04044-7

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Elucidation of underlying molecular mechanism of 5-Fluorouracil chemoresistance and its restoration using fish oil in experimental colon carcinoma

Autor: Rajendra Prasad, Satinder Kaur, Prerna Sharma, Isha Rani, B.C. Sharma, Sandeep Kumar, Navneet Agnihotri

Publikováno v: Molecular and Cellular Biochemistry. 476:1517-1527

Latest strategies for cancer treatment primarily focus on the use of chemosensitizers to enhance therapeutic outcome. N-3 PUFAs have emerged as the strongest candidate for the prevention of colorectal cancer (CRC). Our previous studies have demonstra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e79e517b46d49f7fd063d0da2730e33
https://doi.org/10.1007/s11010-020-03999-x

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Synthesis and In Vitro Analysis of 1‐Deoxysphingolipid Ceramide Analogues via UGI Reaction as Potential Anti‐cancer Agents

Autor: Parleen Kaur, Swati Sihag, Monika Chauhan, Neelima Dhingra, Navneet Agnihotri, Ramandeep Kaur, Vasundhara Singh

Publikováno v: ChemistrySelect. 7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8714c70889cedf776e9b044717454049
https://doi.org/10.1002/slct.202104062

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Sphingolipids: A Roadmap from Biomarker Identification to Clinical Application

Autor: Priyanka Bhadwal, Navneet Agnihotri

Publikováno v: Biomedical Translational Research ISBN: 9789811643446

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a31430fe26020f3c77fee3dc8c759f0
https://doi.org/10.1007/978-981-16-4345-3_27

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Glutamine conjugated organotin(IV) Schiff base compounds: Synthesis, structure, and anticancer properties

Autor: Ramandeep Kaur, Vinay Randhawa, Navneet Agnihotri, Raghubir Singh, Shagun Sharma, Keshav Kumar, Varinder Kaur, Swati Sihag

Publikováno v: Applied Organometallic Chemistry. 36

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a88f0d0253a20fe53bdeedb1ed6b586
https://doi.org/10.1002/aoc.6521

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Akademický článek

Fish oil suppresses cell growth and metastatic potential by regulating PTEN and NF-κB signaling in colorectal cancer.

Autor: Shevali Kansal, Archana Bhatnagar, Navneet Agnihotri

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e84627 (2014)

Homeostasis in eukaryotic tissues is tightly regulated by an intricate balance of the prosurvival and antisurvival signals. The tumor suppressor PTEN (phosphatase and tensin homolog deleted on chromosome 10), a dual-specificity phosphatase, plays a f

Externí odkaz: https://doaj.org/article/3f406e6fd7cb4c19a4f2a79f15f67e9d

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