Zobrazeno 1 - 10
of 835
pro vyhledávání: '"Navitoclax"'
Autor:
Tri Duc Lam, István Tóth, Anca Hermenean, Imola Wilhelm, Claudine Kieda, István Krizbai, Attila E. Farkas
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Background One of the most severe consequences of ageing is cognitive decline, which is associated with dysfunction of the brain microvasculature. Thus, repairing the brain vasculature could result in healthier brain function. Methods To bet
Externí odkaz:
https://doaj.org/article/62658528a08a485193c9083ec3f4004a
Autor:
Vishal Basu, Shabnam, Yamini Murghai, Maqsood Ali, Swetangini Sahu, Bhupendra K. Verma, Mahendra Seervi
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Mitochondria-targeting agents, known as mitocans, are emerging as potent cancer therapeutics due to pronounced metabolic and apoptotic adaptations in the mitochondria of cancer cells. ONC212, an imipridone-family compound initially identifie
Externí odkaz:
https://doaj.org/article/a00fb52483c646c6aa563d37428e8d0d
Autor:
Antonio Cigliano, Isabella Gigante, Marina Serra, Gianpaolo Vidili, Maria M. Simile, Sara Steinmann, Francesco Urigo, Eleonora Cossu, Giovanni M. Pes, Maria P. Dore, Silvia Ribback, Egle P. Milia, Elena Pizzuto, Serena Mancarella, Li Che, Rosa M. Pascale, Gianluigi Giannelli, Matthias Evert, Xin Chen, Diego F. Calvisi
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-17 (2024)
Abstract Background Intrahepatic cholangiocarcinoma (iCCA) is a lethal primary liver tumor characterized by clinical aggressiveness, poor prognosis, and scarce therapeutic possibilities. Therefore, new treatments are urgently needed to render this di
Externí odkaz:
https://doaj.org/article/4358a36380b8455e977ec4053d406fe2
Autor:
Jingmeng Liu, Taojie Zhou, Yangyang Bao, Changjian Lin, Qiujing Chen, Yang Dai, Ning Zhang, Wenqi Pan, Qi Jin, Lin Lu, Qiang Zhao, Tianyou Ling, Liqun Wu
Publikováno v:
Heliyon, Vol 10, Iss 19, Pp e37366- (2024)
Background: Cellular senescence is pivotal in the occurrence and progression of atrial fibrillation (AF). This study aimed to identify senescence-related genes that could be potential therapeutic biomarkers for AF. Methods: AF-related differentially
Externí odkaz:
https://doaj.org/article/5aa45abed98c43d1836b588dd9a19e3d
Autor:
Katja Korelin, Mayke Oostveen, Wafa Wahbi, Filipp Ianevski, Bruno Cavalcante, Laura Turunen, Ilya Belevich, Ahmed Al-Samadi, Tuula Salo
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116719- (2024)
Introduction: Head and neck squamous cell carcinoma (HNSCC) is a common cancer with a five-year survival rate around 60%, indicating a need for new treatments. BH3 mimetics are small molecules that inhibit anti-apoptotic Bcl-2 family proteins, result
Externí odkaz:
https://doaj.org/article/35a14f8a81ff403c8b1964a67d2dda0c
Autor:
Chiara Annunziata, Francesca Castoldi, Jan Schlegel, Hazel X. Ang, Mina Ristovska, Stefania Melini, Robert Welch, Christian G. Riedel, Federico Pietrocola
Publikováno v:
Cell Stress, Vol 7, Iss 12, Pp 105-111 (2023)
The increased burden of senescent cells is as a well-established hallmark of aging and age-related diseases. This finding sparked significant interest in the identification of molecules capable of selectively eliminating senescent cells, so-called se
Externí odkaz:
https://doaj.org/article/4e2a470075264d6a85f71290488ba851
Akademický článek
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Akademický článek
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Akademický článek
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Autor:
Thomas E. Lew, John F. Seymour
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-27 (2022)
Abstract BH3-mimetics are a novel drug class of small molecule inhibitors of BCL2 family proteins which restore apoptosis in malignant cells. The only currently approved BH3-mimetic, the selective BCL2 inhibitor venetoclax, is highly efficacious in c
Externí odkaz:
https://doaj.org/article/1f8c72c5c7ac4af9b178ddd3fce2ea20