Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Navin Rajapakse"'
Autor:
Amer Ali Abd El-Hafeez, Nina Sun, Anirban Chakraborty, Jason Ear, Suchismita Roy, Pranavi Chamarthi, Navin Rajapakse, Soumita Das, Kathryn E. Luker, Tapas K. Hazra, Gary D. Luker, Pradipta Ghosh
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105973- (2023)
Summary: Upon sensing DNA double-strand breaks (DSBs), eukaryotic cells either die or repair DSBs via one of the two competing pathways, i.e., non-homologous end-joining (NHEJ) or homologous recombination (HR). We show that cell fate after DSBs hinge
Externí odkaz:
https://doaj.org/article/cc0d3b44d67a4ef4a0049bb49ba06b5d
Publikováno v:
iScience, Vol 23, Iss 7, Pp 101246- (2020)
Summary: Polarized exocytosis is a fundamental process by which membranes and cargo proteins are delivered to the cell surface with precise spatial control. Although the need for the octameric exocyst complex is conserved from yeast to humans, what i
Externí odkaz:
https://doaj.org/article/fed1d948c92c4011b391be1cfeeb7331
Autor:
Cristina Rohena, Nicholas Kalogriopoulos, Navin Rajapakse, Suchismita Roy, Inmaculada Lopez-Sanchez, Jailal Ablack, Debashis Sahoo, Pradipta Ghosh
Publikováno v:
iScience, Vol 23, Iss 6, Pp 101209- (2020)
Summary: Cells perceive and respond to the extracellular matrix via integrin receptors; their dysregulation has been implicated in inflammation and cancer metastasis. Here we show that a guanine nucleotide-exchange modulator of trimeric-GTPase Gαi,
Externí odkaz:
https://doaj.org/article/c57ce9a32f9c42038e557eee1549c154
Autor:
Kyle Begovich, Angela Schoolmeesters, Navin Rajapakse, Maneesh Kumar, Elena Martinez-Terroba, Arvind Shakya, Brandon Whitefield, Nataraj Pagadala, Aparajita Chourasia, Leah Fung
Publikováno v:
Molecular Cancer Research. 21:B002-B002
Although oncogenic Kirsten rat sarcoma virus (KRAS) was once deemed undruggable, recent advances have revealed promising anti-tumor effects with pan-KRAS and KRAS-mutant specific inhibitors in both preclinical and clinical settings. Despite the succe
Autor:
Kyle Begovich, Angela Schoolmeesters, Navin Rajapakse, Maneesh Kumar, Arvind Shakya, Brandon Whitefield, Elena Martinez-Terroba, Nataraj Pagadala, Shenlin Huang, Aparajita H. Chourasia, Leah Fung
Publikováno v:
Cancer Research. 83:1578-1578
KRAS, a GTPase that regulates cellular growth, is the most frequently mutated oncogene with implications in non-small cell lung, pancreatic and colorectal cancers. Hyperactivation of KRAS in mutant alleles favors KRAS in its active GTP-bound state ov
Autor:
Pranavi Chamarthi, Amer Ali Abd El-Hafeez, Pradipta Ghosh, Kathryn E. Luker, Anirban Chakraborty, Tapas K. Hazra, Navin Rajapakse, Nina N. Sun, Jason Ear, Gary D. Luker, Suchismita Roy, Soumita Das
Summary Upon sensing DNA double-strand breaks (DSBs), eukaryotic cells either die or repair DSBs via one of two competing pathways, i.e., non-homologous end-joining (NHEJ) or homologous recombination (HR). We show that cell fate after DNA damage hing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a84534197053b7ddef44cc136f8f2b5e
https://doi.org/10.1101/2021.07.21.452842
https://doi.org/10.1101/2021.07.21.452842
Autor:
Navin Rajapakse, Pradipta Ghosh, Soni Khandelwal, Majid Ghassemian, Luke McCaffrey, Tony Ngo, Suchismita Roy, Amer Ali Abd El-Hafeez, Jason Ear, Julie Choi, Irina Kufareva, Debashis Sahoo
Publikováno v:
The Journal of Biological Chemistry
PDZ domains are one of the most abundant protein domains in eukaryotes and are frequently found on junction-localized scaffold proteins. Various signaling molecules bind to PDZ proteins via PDZ-binding motifs (PBM) and fine-tune cellular signaling. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0282ea22e2fca657bcf7c2b2975b6dde
https://escholarship.org/uc/item/03d8f26n
https://escholarship.org/uc/item/03d8f26n
Autor:
Julie Choi, Tony Ngo, Suchismita Roy, Irina Kufareva, Majid Ghassemian, Luke McCaffrey, Navin Rajapakse, Amer Ali Abd El-Hafeez, Pradipta Ghosh, Jason Ear, Soni Khandelwal, Debashis Sahoo
PDZ domains are one of the most abundant protein domains in eukaryotes and frequently found on junction-localized scaffold proteins. Various signaling molecules bind to PDZ proteins via PDZ-binding motifs (PBM) and finetune cellular signaling. Here w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd26542f215f29718aa85c9afdf7f118
https://doi.org/10.1101/2020.09.28.317172
https://doi.org/10.1101/2020.09.28.317172
Autor:
Pradipta Ghosh, Peter Novick, Debashis Sahoo, I-Chung Lo, Navin Rajapakse, Cristina C. Rohena
Publikováno v:
iScience, vol 23, iss 7
iScience
iScience, Vol 23, Iss 7, Pp 101246-(2020)
iScience
iScience, Vol 23, Iss 7, Pp 101246-(2020)
Summary Polarized exocytosis is a fundamental process by which membranes and cargo proteins are delivered to the cell surface with precise spatial control. Although the need for the octameric exocyst complex is conserved from yeast to humans, what im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e608309c1f2c59cce075da416aa760f
https://escholarship.org/uc/item/3vq7746f
https://escholarship.org/uc/item/3vq7746f
Autor:
Inmaculada Lopez-Sanchez, Navin Rajapakse, Debashis Sahoo, Nicholas A. Kalogriopoulos, Jailal N. G. Ablack, Cristina C. Rohena, Suchismita Roy, Pradipta Ghosh
Publikováno v:
iScience, vol 23, iss 6
iScience, Vol 23, Iss 6, Pp 101209-(2020)
iScience
iScience, Vol 23, Iss 6, Pp 101209-(2020)
iScience
Summary Cells perceive and respond to the extracellular matrix via integrin receptors; their dysregulation has been implicated in inflammation and cancer metastasis. Here we show that a guanine nucleotide-exchange modulator of trimeric-GTPase Gαi, G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3023ac749efeb1566afc8a4d09f94ecc
https://escholarship.org/uc/item/6222w6f2
https://escholarship.org/uc/item/6222w6f2