Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Navin R Mahadevan"'
Autor:
Varadha Balaji Venkadakrishnan, Adam G. Presser, Richa Singh, Matthew A. Booker, Nicole A. Traphagen, Kenny Weng, Nathaniel C. E. Voss, Navin R. Mahadevan, Kei Mizuno, Loredana Puca, Osasenaga Idahor, Sheng-Yu Ku, Martin K. Bakht, Ashir A. Borah, Zachary T. Herbert, Michael Y. Tolstorukov, David A. Barbie, David S. Rickman, Myles Brown, Himisha Beltran
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase and emerging therapeutic target that is overexpressed in most castration-resistant prostate cancers and implicated as a driver of disease progression and resistance to hormona
Externí odkaz:
https://doaj.org/article/3a09fcc40a5640f5a97df040787fb9ed
Publikováno v:
Journal of Inflammation Research, Vol 2010, Iss default, Pp 99-103 (2010)
Navin R Mahadevan, Antonio Fernandez, Jeffrey J Rodvold, Gonzalo Almanza, Maurizio ZanettiThe Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California, San Diego, USABackground: Several micro-environmental a
Externí odkaz:
https://doaj.org/article/3201d717df9a454294ba10866f94190a
Autor:
Navin R Mahadevan, Veronika Anufreichik, Jeffrey J Rodvold, Kevin T Chiu, Homero Sepulveda, Maurizio Zanetti
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51845 (2012)
Tumor-infiltrating myeloid cells, such as dendritic cells (BMDC), are key regulators of tumor growth. However, the tumor-derived signals polarizing BMDC to a phenotype that subverts cell-mediated anti-tumor immunity have yet to be fully elucidated. A
Externí odkaz:
https://doaj.org/article/63faa7d2af8048af9cf570aed2b5be01
Autor:
Jeffrey Helgager, Hart G. Lidov, Navin R. Mahadevan, Mark W. Kieran, Keith L. Ligon, Sanda Alexandrescu
Publikováno v:
Diagnostic Pathology, Vol 12, Iss 1, Pp 1-6 (2017)
Abstract Background KIAA1549-BRAF fusion is the most common genetic event in pilocytic astrocytoma (PA), and leads to activation of the mitogen activated protein kinase (MAPK) signaling pathway. Fusions of BRAF with other partner genes, as well as ot
Externí odkaz:
https://doaj.org/article/42de6a8713dd41349f70ad3fb6ba3141
Autor:
Satyaki Sengupta, Sanjukta Das, Angela C. Crespo, Annelisa M. Cornel, Anand G. Patel, Navin R. Mahadevan, Marco Campisi, Alaa K. Ali, Bandana Sharma, Jared H. Rowe, Hao Huang, David N. Debruyne, Esther D. Cerda, Malgorzata Krajewska, Ruben Dries, Minyue Chen, Shupei Zhang, Luigi Soriano, Malkiel A. Cohen, Rogier Versteeg, Rudolf Jaenisch, Stefani Spranger, Rizwan Romee, Brian C. Miller, David A. Barbie, Stefan Nierkens, Michael A. Dyer, Judy Lieberman, Rani E. George
Publikováno v:
Nat Cancer
Apart from the anti-GD2 antibody, immunotherapy for neuroblastoma has had limited success due to immune evasion mechanisms, coupled with an incomplete understanding of predictors of response. Here, from bulk and single-cell transcriptomic analyses, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3cd72b8a276f1ae1150701f612b648
https://doi.org/10.1038/s43018-022-00427-5
https://doi.org/10.1038/s43018-022-00427-5
Autor:
Ryohei Yoshida, Maria Saigi, Tetsuo Tani, Benjamin F. Springer, Hirofumi Shibata, Shunsuke Kitajima, Navin R. Mahadevan, Marco Campisi, William Kim, Yoshihisa Kobayashi, Tran C. Thai, Koji Haratani, Yurie Yamamoto, Shriram K. Sundararaman, Erik H. Knelson, Amir Vajdi, Israel Canadas, Ravindra Uppaluri, Cloud P. Paweletz, Juan J. Miret, Patrick H. Lizotte, Prafulla C. Gokhale, Pasi A. Jänne, David A. Barbie
Publikováno v:
Cancer Res
Immunotherapy has shown limited efficacy in patients with EGFR-mutated lung cancer. Efforts to enhance the immunogenicity of EGFR-mutated lung cancer have been unsuccessful to date. Here, we discover that MET amplification, the most common mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66fc59c8a4cf2b0eba8513f1a0487030
https://doi.org/10.1158/0008-5472.can-22-0770
https://doi.org/10.1158/0008-5472.can-22-0770
Autor:
David A. Barbie, Raphael Bueno, Cloud P. Paweletz, Rizwan Romee, Michael Y. Tolstorukov, Juan J. Miret, Pasi A. Jänne, Eric L. Smith, Neil Lineberry, Alexander Parent, Richard C. Gregory, Vicky A. Appleman, Adnan O. Abu-Yousif, William G. Richards, Assunta De Rienzo, Marina Vivero, Israel Cañadas, Ze-Hua Li, Pinar O. Eser, Antja-Voy Hartley, Thomas P. Albertson, Timothy J. Haggerty, Kartika Venugopal, Corinne E. Gustafson, Tran C. Thai, Saemi Han, Arrien A. Bertram, Minh Ha, Ha V. Vo, Ari Zlota, Anna M. Lee-Hassett, Pieter J. Schol, Tetsuo Tani, Navin R. Mahadevan, Erin Shannon, Cameron M. Messier, Bonje Obua, Nathaniel Spicer, Brandon Piel, Minyue Chen, Brittany Meisenheimer, Moataz Noureddine, Ismail Ozgenc, Matthew A. Booker, Patrick H. Lizotte, Marco Campisi, Mubin Tarannum, Elena V. Ivanova, Erik H. Knelson
Activation of the stimulator of interferon genes (STING) pathway promotes antitumor immunity but STING agonists have yet to achieve clinical success. Increased understanding of the mechanism of action of STING agonists in human tumors is key to devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34335b05bd2da45a66fc885095d546f7
https://doi.org/10.1158/2326-6066.c.6550907
https://doi.org/10.1158/2326-6066.c.6550907
Autor:
David A. Barbie, Raphael Bueno, Cloud P. Paweletz, Rizwan Romee, Michael Y. Tolstorukov, Juan J. Miret, Pasi A. Jänne, Eric L. Smith, Neil Lineberry, Alexander Parent, Richard C. Gregory, Vicky A. Appleman, Adnan O. Abu-Yousif, William G. Richards, Assunta De Rienzo, Marina Vivero, Israel Cañadas, Ze-Hua Li, Pinar O. Eser, Antja-Voy Hartley, Thomas P. Albertson, Timothy J. Haggerty, Kartika Venugopal, Corinne E. Gustafson, Tran C. Thai, Saemi Han, Arrien A. Bertram, Minh Ha, Ha V. Vo, Ari Zlota, Anna M. Lee-Hassett, Pieter J. Schol, Tetsuo Tani, Navin R. Mahadevan, Erin Shannon, Cameron M. Messier, Bonje Obua, Nathaniel Spicer, Brandon Piel, Minyue Chen, Brittany Meisenheimer, Moataz Noureddine, Ismail Ozgenc, Matthew A. Booker, Patrick H. Lizotte, Marco Campisi, Mubin Tarannum, Elena V. Ivanova, Erik H. Knelson
Supplementary Data from Activation of Tumor-Cell STING Primes NK-Cell Therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a5f553fda34db80adc5399773dc6ed3
https://doi.org/10.1158/2326-6066.22545320.v1
https://doi.org/10.1158/2326-6066.22545320.v1
Autor:
David A. Barbie, Matthew G. Oser, Ellis L. Reinherz, Scott Rodig, Robin Edwards, Evisa Gjini, Pasi A. Jänne, Kathleen Pfaff, Michael Y. Tolstorukov, Lynette M. Sholl, Fangxin Hong, Benjamin Chen, Xi-Tao Wang, Ana Lako, Eliezer M. Van Allen, Mark M. Awad, Cloud P. Paweletz, Prafulla C. Gokhale, Brendan Reardon, Hideo Watanabe, Maya Fridrikh, Aoi Akitsu, Shunsuke Kitajima, Israel Cañadas, Takahiko Murayama, Alison D. Santucci, Victor Quadros, Andrew Portell, Patrick H. Lizotte, Luke J. Taus, Michael J. Poitras, Jonathan S. Duke-Cohan, Bruce B. Reinhold, Saemi Han, Brandon Piel, Tran C. Thai, Deli Hong, Marco Campisi, Maria Saigí, Amir Vajdi, Jacquelyn O. Wolff, Erik H. Knelson, Navin R. Mahadevan
Small cell lung carcinoma (SCLC) is highly mutated, yet durable response to immune checkpoint blockade (ICB) is rare. SCLC also exhibits cellular plasticity, which could influence its immunobiology. Here we discover that a distinct subset of SCLC uni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4647caa0d1c61ca9a140b00973df6824
https://doi.org/10.1158/2159-8290.c.6549244.v1
https://doi.org/10.1158/2159-8290.c.6549244.v1
Autor:
David A. Barbie, Matthew G. Oser, Ellis L. Reinherz, Scott Rodig, Robin Edwards, Evisa Gjini, Pasi A. Jänne, Kathleen Pfaff, Michael Y. Tolstorukov, Lynette M. Sholl, Fangxin Hong, Benjamin Chen, Xi-Tao Wang, Ana Lako, Eliezer M. Van Allen, Mark M. Awad, Cloud P. Paweletz, Prafulla C. Gokhale, Brendan Reardon, Hideo Watanabe, Maya Fridrikh, Aoi Akitsu, Shunsuke Kitajima, Israel Cañadas, Takahiko Murayama, Alison D. Santucci, Victor Quadros, Andrew Portell, Patrick H. Lizotte, Luke J. Taus, Michael J. Poitras, Jonathan S. Duke-Cohan, Bruce B. Reinhold, Saemi Han, Brandon Piel, Tran C. Thai, Deli Hong, Marco Campisi, Maria Saigí, Amir Vajdi, Jacquelyn O. Wolff, Erik H. Knelson, Navin R. Mahadevan
Supplementary Table S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bdb01871ac4703e7fdf6229583a3de7
https://doi.org/10.1158/2159-8290.22540003.v1
https://doi.org/10.1158/2159-8290.22540003.v1