Výsledky vyhledávání - "Navin L. Rao"

Akademický článek

Cytotoxic CD8+ T cells target citrullinated antigens in rheumatoid arthritis

Autor: Jae-Seung Moon, Shady Younis, Nitya S. Ramadoss, Radhika Iyer, Khushboo Sheth, Orr Sharpe, Navin L. Rao, Stephane Becart, Julie A. Carman, Eddie A. James, Jane H. Buckner, Kevin D. Deane, V. Michael Holers, Susan M. Goodman, Laura T. Donlin, Mark M. Davis, William H. Robinson

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

The immune mechanisms underlying synovitis and joint tissue destruction in rheumatoid arthritis (RA) remain incompletely defined. Here, the authors demonstrate that ACPA+ RA patients have activated clonally expanded cytotoxic GZMB+ CD8+ T cells in bl

Externí odkaz: https://doaj.org/article/256fdecef1e149f1a62547c63372d7f7

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Akademický článek

Differential expansion of T peripheral helper cells in early rheumatoid arthritis and osteoarthritis synovium

Autor: Susanna M Proudman, Ling-Yang Hao, William Murray-Brown, Helen Weedon, Malcolm D Smith, Mihir D Wechalekar, Susan E Lester, Sunil Nagpal, Yanxia Guo, Annabelle Small, Katie Lowe, Navin L Rao

Publikováno v: RMD Open, Vol 8, Iss 2 (2022)

Objectives Programmed cell death protein 1 (PD-1)-expressing T cells are implicated in the pathogenesis of autoimmune inflammatory diseases such as rheumatoid arthritis. A subset of CXCR5− T cells, termed T peripheral helper (Tph) cells, which driv

Externí odkaz: https://doaj.org/article/f7fc10303c3b466ab3977cd24072ecdf

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Akademický článek

The role of posttranslational modifications in generating neo-epitopes that bind to rheumatoid arthritis-associated HLA-DR alleles and promote autoimmune T cell responses.

Autor: Stephane Becart, Karen B Whittington, Amanda Prislovsky, Navin L Rao, Edward F Rosloniec

Publikováno v: PLoS ONE, Vol 16, Iss 1, p e0245541 (2021)

While antibodies to citrullinated proteins have become a diagnostic hallmark in rheumatoid arthritis (RA), we still do not understand how the autoimmune T cell response is influenced by these citrullinated proteins. To investigate the role of citrull

Externí odkaz: https://doaj.org/article/329c055308a6492b9e793275457ab734

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Diversity and Clonality of T Cell Receptor Repertoire and Antigen Specificities in Small Joints of Early Rheumatoid Arthritis

Publikováno v: Arthritis & Rheumatology. 75:673-684

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::182d862e41f292d175f2242048da117e
https://doi.org/10.1002/art.42407

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Akademický článek

Cohort profile of a US military population for evaluating pre-disease and disease serological biomarkers in rheumatoid and reactive arthritis: Rationale, organization, design, and baseline characteristics

Autor: Chad K. Porter, Mark S. Riddle, Renee M. Laird, Matthew Loza, Suzanne Cole, Christina Gariepy, Ashley Alcala, Ramiro Gutierréz, Frédéric Baribaud, Navin L. Rao, Sunil Nagpal

Publikováno v: Contemporary Clinical Trials Communications, Vol 17, Iss , Pp - (2020)

Purpose: The etiology of several autoimmune disorders, including rheumatoid arthritis, remains unknown. While there are clear phases of disease progression, the mechanisms of transition between these phases are poorly understood. Additionally, treatm

Externí odkaz: https://doaj.org/article/034a39954cfc48f6999d521469598135

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Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase

Publikováno v: Journal of Medicinal Chemistry. 65:14326-14336

Bruton's tyrosine kinase (BTK) is a Tec family kinase that plays an essential role in B-cell receptor (BCR) signaling as well as Fcγ receptor signaling in leukocytes. Pharmacological inhibition of BTK has been shown to be effective in treating hemat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b6932f837c19dc6e82c72e8534354a
https://doi.org/10.1021/acs.jmedchem.2c01026

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Cytotoxic CD8+T cells target citrullinated antigens in rheumatoid arthritis

The immune mechanisms that mediate synovitis and joint destruction in rheumatoid arthritis (RA) remain poorly defined. Although increased levels of CD8+T cells have been described in RA, their role in pathogenesis remains unclear. Here we perform sin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57b50f886706e2785f80c79f11b44dab
https://doi.org/10.1101/2022.11.10.22282203

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The T cell receptor repertoire and antigen specificities in small joints of early rheumatoid arthritis - diversity and clonality

Publikováno v: Arthritisrheumatology (Hoboken, N.J.).

CD4+ T cells are implicated in rheumatoid arthritis (RA) pathology from the strong association between RA and certain HLA-class II gene variants. Here, we studied the synovial T cell receptor (TCR) repertoire, T cell phenotypes and T cell specificiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5dce9d27be90cca7cdd8c971c05515b9
https://pubmed.ncbi.nlm.nih.gov/36409582

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Serologic Biomarkers of Progression Toward Diagnosis of Rheumatoid Arthritis in Active Component Military Personnel

Autor: Matthew J. Loza, Sunil Nagpal, Suzanne Cole, Renee M. Laird, Ashley Alcala, Navin L. Rao, Mark S. Riddle, Chad K. Porter

Publikováno v: Arthritisrheumatology (Hoboken, N.J.)REFERENCES. 74(11)

To identify a panel of serum biomarkers that could specifically identify imminent cases of rheumatoid arthritis (RA) before diagnosis.Serum samples were collected at 4 time points from active component US military personnel, including 157 anti-citrul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f92ae0392ebc922f310b05ac6879cb
https://pubmed.ncbi.nlm.nih.gov/35671369

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