Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Navin L Rao"'
Autor:
Susanna M Proudman, Ling-Yang Hao, William Murray-Brown, Helen Weedon, Malcolm D Smith, Mihir D Wechalekar, Susan E Lester, Sunil Nagpal, Yanxia Guo, Annabelle Small, Katie Lowe, Navin L Rao
Publikováno v:
RMD Open, Vol 8, Iss 2 (2022)
Objectives Programmed cell death protein 1 (PD-1)-expressing T cells are implicated in the pathogenesis of autoimmune inflammatory diseases such as rheumatoid arthritis. A subset of CXCR5− T cells, termed T peripheral helper (Tph) cells, which driv
Externí odkaz:
https://doaj.org/article/f7fc10303c3b466ab3977cd24072ecdf
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245541 (2021)
While antibodies to citrullinated proteins have become a diagnostic hallmark in rheumatoid arthritis (RA), we still do not understand how the autoimmune T cell response is influenced by these citrullinated proteins. To investigate the role of citrull
Externí odkaz:
https://doaj.org/article/329c055308a6492b9e793275457ab734
Autor:
Sara Turcinov, Erik af Klint, Bertrand Van Schoubroeck, Arlette Kouwenhoven, Sohel Mia, Karine Chemin, Hans Wils, Carl Van Hove, An De Bondt, Ken Keustermans, Jeroen Van Houdt, Joke Reumers, Nathan Felix, Navin L. Rao, Pieter Peeters, Frederik Stevenaert, Lars Klareskog, Murray McKinnon, Daniel Baker, Anish Suri, Vivianne Malmström
Publikováno v:
Arthritis & Rheumatology. 75:673-684
Autor:
Chad K. Porter, Mark S. Riddle, Renee M. Laird, Matthew Loza, Suzanne Cole, Christina Gariepy, Ashley Alcala, Ramiro Gutierréz, Frédéric Baribaud, Navin L. Rao, Sunil Nagpal
Publikováno v:
Contemporary Clinical Trials Communications, Vol 17, Iss , Pp - (2020)
Purpose: The etiology of several autoimmune disorders, including rheumatoid arthritis, remains unknown. While there are clear phases of disease progression, the mechanisms of transition between these phases are poorly understood. Additionally, treatm
Externí odkaz:
https://doaj.org/article/034a39954cfc48f6999d521469598135
Autor:
Mark S. Tichenor, John J. M. Wiener, Navin L. Rao, Genesis M. Bacani, Jianmei Wei, Charlotte Pooley Deckhut, J. Kent Barbay, Kevin D. Kreutter, Leon Chang, Kathleen W. Clancy, Heather E. Murrey, Weixue Wang, Kay Ahn, Michael Huber, Elizabeth Rex, Kevin J. Coe, Jiejun Wu, Haopeng Rui, Kia Sepassi, Marcello Gaudiano, Mariette Bekkers, Ivo Cornelissen, Kathryn Packman, Mark Seierstad, Christos Xiouras, Scott D. Bembenek, Richard Alexander, Cynthia Milligan, Sriram Balasubramanian, Alec D. Lebsack, Jennifer D. Venable, Ulrike Philippar, James P. Edwards, Gavin Hirst
Publikováno v:
Journal of Medicinal Chemistry. 65:14326-14336
Bruton's tyrosine kinase (BTK) is a Tec family kinase that plays an essential role in B-cell receptor (BCR) signaling as well as Fcγ receptor signaling in leukocytes. Pharmacological inhibition of BTK has been shown to be effective in treating hemat
Autor:
Jae-Seung Moon, Shady Younis, Nitya S. Ramadoss, Radhika Iyer, Khushboo Sheth, Orr Sharpe, Navin L. Rao, Stephane Becart, Julie A. Carman, Eddie A. James, Jane H. Buckner, Kevin D. Deane, V. Michael Holers, Susan M. Goodman, Laura T. Donlin, Mark M. Davis, William H. Robinson
Publikováno v:
Nature Communications. 14
The immune mechanisms that mediate synovitis and joint destruction in rheumatoid arthritis (RA) remain poorly defined. Although increased levels of CD8+ T cells have been described in RA, their function in pathogenesis remains unclear. Here we perfor
Autor:
Jae-Seung Moon, Shady Younis, Nitya S. Ramadoss, Radhika Iyer, Khushboo Sheth, Orr Sharpe, Navin L. Rao, Stephane Becart, Julie A. Carman, Eddie A. James, Jane H. Buckner, Kevin D. Deane, V. Michael Holers, Susan M. Goodman, Laura T. Donlin, Mark M. Davis, William H. Robinson
The immune mechanisms that mediate synovitis and joint destruction in rheumatoid arthritis (RA) remain poorly defined. Although increased levels of CD8+T cells have been described in RA, their role in pathogenesis remains unclear. Here we perform sin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57b50f886706e2785f80c79f11b44dab
https://doi.org/10.1101/2022.11.10.22282203
https://doi.org/10.1101/2022.11.10.22282203
Autor:
Sara, Turcinov, Erik, Af Klint, Bertrand, Van Schoubroeck, Arlette, Kouwenhoven, Sohel, Mia, Karine, Chemin, Hans, Wils, Carl, Van Hove, An, De Bondt, Ken, Keustermans, Jeroen, Van Houdt, Joke, Reumers, Nathan, Felix, Navin L, Rao, Pieter, Peeters, Frederik, Stevenaert, Lars, Klareskog, Murray, McKinnon, Daniel, Baker, Anish, Suri, Vivianne, Malmström
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.).
CD4+ T cells are implicated in rheumatoid arthritis (RA) pathology from the strong association between RA and certain HLA-class II gene variants. Here, we studied the synovial T cell receptor (TCR) repertoire, T cell phenotypes and T cell specificiti
Autor:
Matthew J. Loza, Sunil Nagpal, Suzanne Cole, Renee M. Laird, Ashley Alcala, Navin L. Rao, Mark S. Riddle, Chad K. Porter
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.)REFERENCES. 74(11)
To identify a panel of serum biomarkers that could specifically identify imminent cases of rheumatoid arthritis (RA) before diagnosis.Serum samples were collected at 4 time points from active component US military personnel, including 157 anti-citrul
Autor:
William Murray-Brown, Yanxia Guo, Annabelle Small, Katie Lowe, Helen Weedon, Malcolm D Smith, Susan E Lester, Susanna M Proudman, Navin L Rao, Ling-Yang Hao, Sunil Nagpal, Mihir D Wechalekar
Publikováno v:
RMD Open. 8:e002563
ObjectivesProgrammed cell death protein 1 (PD-1)-expressing T cells are implicated in the pathogenesis of autoimmune inflammatory diseases such as rheumatoid arthritis. A subset of CXCR5−T cells, termed T peripheral helper (Tph) cells, which drive