Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Navid Sahebekhtiari"'
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Akademický článek
Molecular pathways behind acquired obesity: Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI
Autor: Birgitta W. van der Kolk, Sina Saari, Alen Lovric, Muhammad Arif, Marcus Alvarez, Arthur Ko, Zong Miao, Navid Sahebekhtiari, Maheswary Muniandy, Sini Heinonen, Ali Oghabian, Riikka Jokinen, Sakari Jukarainen, Antti Hakkarainen, Jesper Lundbom, Juho Kuula, Per-Henrik Groop, Taru Tukiainen, Nina Lundbom, Aila Rissanen, Jaakko Kaprio, Evan G. Williams, Nicola Zamboni, Adil Mardinoglu, Päivi Pajukanta, Kirsi H. Pietiläinen
Publikováno v: Cell Reports Medicine, Vol 2, Iss 4, Pp 100226- (2021)
Summary: Tissue-specific mechanisms prompting obesity-related development complications in humans remain unclear. We apply multiomics analyses of subcutaneous adipose tissue and skeletal muscle to examine the effects of acquired obesity among 49 BMI-
Externí odkaz: https://doaj.org/article/4bc712e3168444c09fa1c3ff1ed257df
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2
Deficiency of the mitochondrial sulfide regulator ETHE1 disturbs cell growth, glutathione level and causes proteome alterations outside mitochondria
Autor: Peter Bross, Johan Palmfeldt, Navid Sahebekhtiari, Paula Fernandez-Guerra, Zahra Nochi, Jasper Carlsen
Publikováno v: Sahebekhtiari, N, Fernandez-Guerra, P, Nochi, Z, Carlsen, J, Bross, P & Palmfeldt, J 2019, ' Deficiency of the mitochondrial sulfide regulator ETHE1 disturbs cell growth, glutathione level and causes proteome alterations outside mitochondria. ', B B A-Molecular Basis of Disease, vol. 1865, no. 1, pp. 126-135 . https://doi.org/10.1016/j.bbadis.2018.10.035
The mitochondrial enzyme ETHE1 is a persulfide dioxygenase essential for cellular sulfide detoxification, and its deficiency causes the severe and complex inherited metabolic disorder ethylmalonic encephalopathy (EE). In spite of well-described clini
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc9619f0142c963832f78a4bd9b9297c
https://doi.org/10.1016/j.bbadis.2018.10.035
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3
The mitochondrial proteomic signatures of human skeletal muscle linked to insulin resistance
Autor: Navid Sahebekhtiari, Kurt Højlund, Rikke Kruse
Publikováno v: Kruse, R, Sahebekhtiari, N & Højlund, K 2020, ' The mitochondrial proteomic signatures of human skeletal muscle linked to insulin resistance ', International Journal of Molecular Sciences, vol. 21, no. 15, 5374 . https://doi.org/10.3390/ijms21155374
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 5374, p 5374 (2020)
Kruse, R, Sahebekhtiari, N & Højlund, K 2020, ' The Mitochondrial Proteomic Signatures of Human Skeletal Muscle Linked to Insulin Resistance ', International Journal of Molecular Sciences, vol. 21, no. 15 . https://doi.org/10.3390/ijms21155374
Introduction: Mitochondria are essential in energy metabolism and cellular survival, and there is growing evidence that insulin resistance in chronic metabolic disorders, such as obesity, type 2 diabetes (T2D), and aging, is linked to mitochondrial d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4836df4063899b2c8b392216520e71c9
https://findresearcher.sdu.dk:8443/ws/files/172003442/ijms_21_05374_v2.pdf
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5
Untargeted Metabolomics Analysis Reveals a Link between ETHE1-Mediated Disruptive Redox State and Altered Metabolic Regulation
Autor: Mogens Johannsen, Johan Palmfeldt, Navid Sahebekhtiari, Camilla Bak Nielsen
Publikováno v: Sahebekhtiari, N, Nielsen, C B, Johannsen, M & Palmfeldt, J 2016, ' Untargeted Metabolomics Analysis Reveals a Link between ETHE1-Mediated Disruptive Redox State and Altered Metabolic Regulation ', Journal of Proteome Research . https://doi.org/10.1021/acs.jproteome.6b00100
Defects in the gene encoding the persulfide dioxygenase ETHE1 are known to cause the severe inherited metabolic disorder ethylmalonic encephalopathy (EE). In spite of known clinical characteristics, the molecular mechanisms underlying the ETHE1 defic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b05a04395a302e1afdc8f70c9428b9f7
https://doi.org/10.1021/acs.jproteome.6b00100
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6
Quantitative proteomics suggests metabolic reprogramming during ETHE1 deficiency
Autor: Johan Palmfeldt, Michelle M. Thomsen, Navid Sahebekhtiari, Carlo Viscomi, Massimo Zeviani, Jens Jørgen Sloth, Vibeke Stenbroen, Niels Gregersen
Publikováno v: Sahebekhtiari, N, Thomsen, M M, Sloth, J J, Stenbroen, V, Zeviani, M, Gregersen, N, Viscomi, C & Palmfeldt, J 2016, ' Quantitative proteomics suggests metabolic reprogramming during ETHE1 deficiency ', Proteomics . https://doi.org/10.1002/pmic.201500336
Sahebekhtiari, N, Thomsen, M M, Sloth, J J, Stenbroen, V, Zeviani, M, Gregersen, N, Viscomi, C & Palmfeldt, J 2016, ' Quantitative proteomics suggests metabolic reprogramming during ETHE1 deficiency ', Proteomics, vol. 16, no. 7, pp. 1667-1176 . https://doi.org/10.1002/pmic.201500336
Deficiency of mitochondrial sulfur dioxygenase (ETHE1) causes the severe metabolic disorder ethylmalonic encephalopathy, which is characterized by early-onset encephalopathy and defective cytochrome C oxidase because of hydrogen sulfide accumulation.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cecac0cea24907f27d52b666b22ba6df
https://doi.org/10.1002/pmic.201500336
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7
Analysis of 3′-end variable region of thecagAgene inHelicobacter pyloriisolated from Iranian population
Autor: Yoshio Yamaoka, Ali Tahami, Mohammad Reza Zali, Kaveh Baghaei, Navid Sahebekhtiari, Hossein Dabiri, Fereshteh Jafari, Homayon Zojaji, Mitsushige Sugimoto, Leila Shokrzadeh
Publikováno v: Journal of Gastroenterology and Hepatology. 25:172-177
Background and Aims: The 3′ region of the cagA gene, the most well-known virulence factor of Helicobacter pylori, contains Glu-Pro-Ile-Tyr-Ala (EPIYA) motifs. Four segments flanking the EPIYA motifs, EPIYA-A, -B, -C, or -D, were reported to play im
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2270eff1a48269587a86ca255681b9d0
https://doi.org/10.1111/j.1440-1746.2009.05979.x
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8
Analysis of Helicobacter pylori Genotypes in Afghani and Iranian Isolates
Autor: Maryam Rezadehbashi, Mehdi Bolfion, Leila Shokrzadeh, Mohammad Reza Zali, Fereshteh Jafari, Akbar Mirsalehian, Yoshio Yamaoka, Darioush Mirsattari, Hossein Dabiri, Homayon Zojaji, Navid Sahebekhtiari
Publikováno v: Scopus-Elsevier
Europe PubMed Central
The geographical variation in Helicobacter pylori genotypes is an observed phenomenon. Cytotoxin associated genes A (cagA) and E (cagE), and vacuolating cytotoxin (vacA) genotypes of H. pylori are associated with peptic ulcer disease (PUD). This stud
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266906c4664864f4a9f05f8299c04c68
https://doi.org/10.33073/pjm-2010-009
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Comparison of 16S rRNA, 23S rRNA andgyrB genes sequences in phylogenetic relationships ofShigella isolates from Iran
Autor: Navid Sahebekhtiari, Haleh Edalatkhah, Babak Noorinayer, Mohammad Reza Zali, Fereshteh Jafari, Kamyar Motavaze, Hossein Dabiri, Z. Nochi, Mohsen Chiani, Pedram Kharaziha
Publikováno v: Annals of Microbiology. 59:615-622
Phylogenetic analysis of about twenty isolates ofShigella spp. was carried out using the nucleotide sequences of 16S rRNA, 23S rRNA and DNA gyrase B (gyrB) genes which was determined by directly sequencing PCR fragments. The results showed that the s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2fce546bcbfec30282fc5b9951cb3cb0
https://doi.org/10.1007/bf03175154
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