Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Navid, Paknejad"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Inositol 1,4,5-trisphosphate receptors (IP3Rs) are endoplasmic reticulum Ca2+ channels whose biphasic dependence on cytosolic Ca2+ gives rise to Ca2+ oscillations that regulate fertilization, cell division and cell death. Despite the critica
Externí odkaz:
https://doaj.org/article/8d3dbc1232e647bebd996269938e7911
Autor:
Minfei Su, Navid Paknejad, Lan Zhu, Jinan Wang, Hung Nguyen Do, Yinglong Miao, Wei Liu, Richard K. Hite, Xin-Yun Huang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Su et al. report cryo-EM structures of β1-adrenergic receptor, Gs and ligands of different efficacies. These complexes have similar overall architecture, but with local conformational differences and different stabilities.
Externí odkaz:
https://doaj.org/article/c1df6479c5ba4cfb9c48c1795f9bfd9e
Autor:
Shian Liu, Navid Paknejad, Lan Zhu, Yasuyuki Kihara, Manisha Ray, Jerold Chun, Wei Liu, Richard K. Hite, Xin-Yun Huang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Liu et al. report structures of human sphingosine 1-phosphate (S1P) receptor 1 (S1P1) in complex with Gi and S1P or the multiple sclerosis (MS) drug Siponimod, as well as human lysophosphatidic acid (LPA) receptor 1 (LPA1) in complex with Gi and LPA,
Externí odkaz:
https://doaj.org/article/58134eb70a4a45f6ab8809cc247dec49
Publikováno v:
eLife, Vol 9 (2020)
Transmembrane protein 175 (TMEM175) is a K+-selective ion channel expressed in lysosomal membranes, where it establishes a membrane potential essential for lysosomal function and its dysregulation is associated with the development of Parkinson’s D
Externí odkaz:
https://doaj.org/article/881d21d9296142f7ba943dcb658d7580
Autor:
Navid Paknejad, Gholamreza Latifi
Publikováno v:
برنامهریزی توسعه شهری و منطقهای, Vol 3, Iss 5, Pp 29-53 (2018)
Analyzing the structure of urban space over time and analyzing the characteristics of texture lead to understanding the formation of behavior and behavioral patterns in the physical structure, and this creates the conditions for planning for the emer
Externí odkaz:
https://doaj.org/article/0e9d96a9bcab4a10840e18eeef2f6763
SummaryInositol 1,4,5-trisphosphate receptors (IP3Rs) are intracellular Ca2+-permeable cation channels whose biphasic dependence on cytoplasmic Ca2+gives rise to cytosolic Ca2+oscillations that regulate fertilization, cell division and cell death. De
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05ca0e4476c2b4860b7d4faff4d4692f
https://doi.org/10.1101/2022.12.29.522241
https://doi.org/10.1101/2022.12.29.522241
Autor:
Joel R. Meyerson, Richard K Hite, Edward T. Eng, Jian-Shu Lou, Jianyun Huang, Kelsey D. Jordan, Xin-Yun Huang, Minfei Su, Kamela O. Alegre, Navid Paknejad
Publikováno v:
Nat Struct Mol Biol
The β1-adrenergic receptor (β1-AR) can activate two families of G proteins. When coupled to Gs, β1-AR increases cardiac output, and coupling to Gi leads to decreased responsiveness in myocardial infarction. By comparative structural analysis of tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbbaffe1f5d6ad2bd526fed3095666b2
https://doi.org/10.1038/s41594-021-00679-2
https://doi.org/10.1038/s41594-021-00679-2
Autor:
Shian Liu, Navid Paknejad, Lan Zhu, Yasuyuki Kihara, Manisha Ray, Jerold Chun, Wei Liu, Richard K. Hite, Xin-Yun Huang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Lysophospholipids are bioactive lipids and can signal through G-protein-coupled receptors (GPCRs). The best studied lysophospholipids are lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). The mechanisms of lysophospholipid recognition by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362d9617fe6e8cd0344f5f1b887ec319
https://pubmed.ncbi.nlm.nih.gov/35136060
https://pubmed.ncbi.nlm.nih.gov/35136060
Autor:
Elizabeth V. Wasmuth, Arnaud Vanden Broeck, Justin R. LaClair, Elizabeth A. Hoover, Kayla E. Lawrence, Navid Paknejad, Kyrie Pappas, Doreen Matthies, Biran Wang, Weiran Feng, Philip A. Watson, John C. Zinder, Wouter R. Karthaus, M. Jason de la Cruz, Richard K. Hite, Katia Manova-Todorova, Zhiheng Yu, Susan T. Weintraub, Sebastian Klinge, Charles L. Sawyers
Publikováno v:
Molecular Cell. 82:2021-2031.e5
SummaryThe androgen receptor (AR) is a steroid receptor and master transcription factor that governs gene expression programs required for luminal development of prostate epithelium, formation of muscle tissue and maintenance of the male phenotype. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c6df221ecaedafa537ed3a95f5e24af
https://doi.org/10.1016/j.molcel.2022.03.035
https://doi.org/10.1016/j.molcel.2022.03.035
Autor:
Minfei, Su, Navid, Paknejad, Lan, Zhu, Jinan, Wang, Hung Nguyen, Do, Yinglong, Miao, Wei, Liu, Richard K, Hite, Xin-Yun, Huang
Publikováno v:
Nature communications. 13(1)
G-protein-coupled receptors (GPCRs) receive signals from ligands with different efficacies, and transduce to heterotrimeric G-proteins to generate different degrees of physiological responses. Previous studies revealed how ligands with different effi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1a94e7869f3ad6837572348bbe916cdb
https://pubmed.ncbi.nlm.nih.gov/35835792
https://pubmed.ncbi.nlm.nih.gov/35835792