A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope.

Autor: Raman S; Program in Molecular Medicine, Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada., Buongervino SN; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Lane MV; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Zhelev DV; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Zhu Z; Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21701, USA., Cui H; Program in Molecular Medicine, Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada., Martinez B; Program in Molecular Medicine, Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada., Martinez D; Department of Pathology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Wang Y; Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21701, USA., Upton K; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Patel K; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Rathi KS; Department of Biomedical and Health Informatics and Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Navia CT; Integral Molecular, Philadelphia, PA 19104, USA., Harmon DB; Integral Molecular, Philadelphia, PA 19104, USA., Li Y; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Pawel B; Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.; Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA., Dimitrov DS; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Maris JM; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA., Julien JP; Program in Molecular Medicine, Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada.; Departments of Biochemistry and Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada., Bosse KR; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2021 Jul 21; Vol. 2 (7), pp. 100344. Date of Electronic Publication: 2021 Jul 21 (Print Publication: 2021).