Supplementary Data from A Phase II Trial of the Aurora Kinase A Inhibitor Alisertib for Patients with Castration-resistant and Neuroendocrine Prostate Cancer: Efficacy and Biomarkers

Autor: Scott T. Tagawa, Karla V. Ballman, David M. Nanus, Francesca Demichelis, David S. Rickman, Howard I. Scher, Mark A. Rubin, Davide Prandi, Loredana Puca, Etienne Dardenne, Andrea Sboner, Naveen Gumpeni, Alessandro Romanel, Rohan Bareja, Verena Sailer, Juan M. Mosquera, Jacek Pinski, Mark Stein, Andrew J. Armstrong, Ulka Vaishampayan, Russell Z. Szmulewitz, Christopher Hoimes, Bruce Montgomery, Daniel C. Danila, Clara Oromendia, Himisha Beltran

Supplementary Data

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c2e22708cb8d478d210101999356545
https://doi.org/10.1158/1078-0432.22475001.v1

Inhibition of FGF receptor blocks adaptive resistance to RET inhibition in CCDC6-RET-rearranged thyroid cancer

Autor: Renuka Raman, Jacques A. Villefranc, Timothy M. Ullmann, Jessica Thiesmeyer, Viviana Anelli, Jun Yao, James R. Hurley, Chantal Pauli, Rohan Bareja, Kenneth Wha Eng, Princesca Dorsaint, David C. Wilkes, Shaham Beg, Sarah Kudman, Reid Shaw, Michael Churchill, Adnan Ahmed, Laurel Keefer, Ian Misner, Donna Nichol, Naveen Gumpeni, Theresa Scognamiglio, Mark A. Rubin, Carla Grandori, James Patrick Solomon, Wei Song, Juan Miguel Mosquera, Noah Dephoure, Andrea Sboner, Olivier Elemento, Yariv Houvras

Publikováno v: Raman, Renuka; Villefranc, Jacques A; Ullmann, Timothy M; Thiesmeyer, Jessica; Anelli, Viviana; Yao, Jun; Hurley, James R; Pauli, Chantal; Bareja, Rohan; Wha Eng, Kenneth; Dorsaint, Princesca; Wilkes, David C; Beg, Shaham; Kudman, Sarah; Shaw, Reid; Churchill, Michael; Ahmed, Adnan; Keefer, Laurel; Misner, Ian; Nichol, Donna; ... (2022). Inhibition of FGF receptor blocks adaptive resistance to RET inhibition in CCDC6-RET-rearranged thyroid cancer. Journal of experimental medicine, 219(6) Rockefeller University Press 10.1084/jem.20210390

Genetic alterations in RET lead to activation of ERK and AKT signaling and are associated with hereditary and sporadic thyroid cancer and lung cancer. Highly selective RET inhibitors have recently entered clinical use after demonstrating efficacy in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43e8c8db5b3a15fed3b2912932d0a40
https://pubmed.ncbi.nlm.nih.gov/35510953

A Phase II Trial of the Aurora Kinase A Inhibitor Alisertib for Patients with Castration-resistant and Neuroendocrine Prostate Cancer: Efficacy and Biomarkers

Autor: Etienne Dardenne, Himisha Beltran, Russell Z. Szmulewitz, Clara Oromendia, Bruce Montgomery, Alessandro Romanel, Rohan Bareja, Naveen Gumpeni, Christopher J. Hoimes, Karla V. Ballman, Ulka N. Vaishampayan, David S. Rickman, Mark A. Rubin, Loredana Puca, Mark N. Stein, Francesca Demichelis, Jacek Pinski, David M. Nanus, Verena Sailer, Daniel C. Danila, Andrew J. Armstrong, Andrea Sboner, Davide Prandi, Scott T. Tagawa, Howard I. Scher, Juan Miguel Mosquera

Purpose: Neuroendocrine prostate cancer (NEPC) is an aggressive variant of prostate cancer that may develop de novo or as a mechanism of treatment resistance. N-myc is capable of driving NEPC progression. Alisertib inhibits the interaction between N-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb452510e0e899d9923a189907d80c43

Functional outcomes following robotic prostatectomy using athermal, traction free risk-stratified grades of nerve sparing

Autor: Alexandra Peyser, Sheela Metgud, Ashutosh K. Tewari, Francesca Khani, Matthieu Durand, Prasanna Sooriakumaran, Robert Leung, Niyati Harneja, Maria M. Shevchuk, Abhishek Kumar Srivastava, Brian D. Robinson, Jinyi Li, Naveen Gumpeni, Nithin Theckumparampil, Adnan Ali, Siobhan Gruschow, Vinita Asija

OBJECTIVE: To report our unique approach for individualizing robotic prostate cancer surgery by risk stratification and sub classification of the periprostatic space into 4 distinct compartments, and thus performing 4 precise different grades of nerv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::505fbaf484dcab37502e9ca234f43e3b
https://ora.ox.ac.uk/objects/uuid:6479fefe-fa94-40bc-a685-0aed9b9e693f

MP17-12 MOLECULAR ALTERATIONS IN PROSTATE CANCER AND ASSOCIATION WITH MRI FEATURES

Autor: Naveen Gumpeni, Mark A. Rubin, Brian D. Robinson, Andrea Sboner, Jacqueline Fontugne, Christopher E. Barbieri, Daniel J. Lee, Kyung Chan Park, Theresa Y. MacDonald, Juan Miguel Mosquera

Publikováno v: Journal of Urology. 193

BACKGROUND Multiparametric magnetic resonance imaging (mpMRI) has been increasingly used for prostate cancer (PCa). Recent studies identified distinct molecular subclasses of PCa with recurrent genomic alterations. However, the associations between m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5fa55bfb36c8b79ed9e281c34bcce135
https://doi.org/10.1016/j.juro.2015.02.854