Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Navdeep K. Sahota"'
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140975 (2015)
The Nek11 kinase is a potential mediator of the DNA damage response whose expression is upregulated in early stage colorectal cancers (CRCs). Here, using RNAi-mediated depletion, we examined the role of Nek11 in HCT116 WT and p53-null CRC cells expos
Externí odkaz:
https://doaj.org/article/3e53e015bcbe44df8ea10a2252752fe0
Autor:
Navdeep K. Sahota, Samantha Burns, Daniel G. Hayward, Guojie Mao, Paul Workman, Ian Collins, Eilis Byrne, Lisa Pickard, Yvette Newbatt, Wynne Aherne, Andrew M. Fry
Publikováno v:
SLAS Discovery. 15:918-927
Nek2 is a serine/threonine protein kinase that localizes to the centrosome and is implicated in mitotic regulation. Overexpression of Nek2 induces premature centrosome separation and nuclear defects indicative of mitotic errors, whereas depletion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1905cc4756330a37326dfb364ad6bbdd
https://doi.org/10.1177/1087057110376537
https://doi.org/10.1177/1087057110376537
Publikováno v:
The Journal of Cell Biology
The Nek5 protein kinase contributes not only to uncoupling of the centrosome linker but also to integrity of the pericentriolar material and centrosomal microtubule nucleation, which together ensure the timely separation of centrosomes during early m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e526ce6384e365574f7d14502207d3f
http://hdl.handle.net/10379/13526
http://hdl.handle.net/10379/13526
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140975 (2015)
PLoS ONE
PLoS ONE
The Nek11 kinase is a potential mediator of the DNA damage response whose expression is upregulated in early stage colorectal cancers (CRCs). Here, using RNAi-mediated depletion, we examined the role of Nek11 in HCT116 WT and p53-null CRC cells expos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c0d5cb6b70eafc00d3069a53d5b9f1e
http://europepmc.org/articles/PMC4621075?pdf=render
http://europepmc.org/articles/PMC4621075?pdf=render