Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Navasona Krishnan"'
Autor:
Wei Qiu, Qi Sun, Yi Yang, Chirag Patel, Meng Sun, Yue Liu, Kyle Halliwill, Sarah Kim, Rebecca Mathew, Jennifer M Frost, Jennifer A Roth, Domenick Kennedy, Robert T Manguso, Kathleen B Yates, Hakimeh Ebrahimi-Nik, Christina K Baumgartner, Arvin Iracheta-Vellve, Keith M Hamel, Kira Olander, Thomas GR Davis, Kathleen A McGuire, Geoff T Halvorsen, Omar I Avila, Ashwin V Kammula, Audrey J Muscato, Prasanthi Geda, Kelly Klinge, Zhaoming Xiong, Ryan Duggan, Liang Mu, Mitchell D Yeary, James C Patti, Tyler M Balon, Carey Backus, Angeline Chen, Kenton Longenecker, Joseph Klahn, Cara Hrusch, Navasona Krishnan, Charles W Hutchins, Jacqueline Aguado, Marinka Bulic, Payal Tiwari, Kayla J Colvin, Cun Lan Chuong, Ian C Kohnle, Matthew G Rees, Andrew Boghossian, Melissa Ronan, Meng-Ju Wu, Debattama R Sen, Gabriel K Griffin, Nabeel El-Bardeesy, Patricia Trusk, Joshua H Decker, Stacey Fossey, Marcia N Paddock, Elliot P Farney, Clay Beauregard, Philip R Kym
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)
Externí odkaz:
https://doaj.org/article/11356ff1bf1f4b63ab1324cafa253315
Autor:
Eric R. Goedken, Maria A. Argiriadi, Justin D. Dietrich, Andrew M. Petros, Navasona Krishnan, Sanjay C. Panchal, Wei Qiu, Haihong Wu, Haizhong Zhu, Ashley M. Adams, Pierre M. Bodelle, Lucas Goguen, Paul L. Richardson, Peter F. Slivka, Myron Srikumaran, Anup K. Upadhyay, Bainan Wu, Russell A. Judge, Anil Vasudevan, Sujatha M. Gopalakrishnan, Philip B. Cox, Vincent S. Stoll, Chaohong Sun
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Anti-IL17A therapies have proven effective for numerous inflammatory diseases including psoriasis, axial spondylitis and psoriatic arthritis. Modulating and/or antagonizing protein–protein interactions of IL17A cytokine binding to its cell
Externí odkaz:
https://doaj.org/article/73a129f16e244becaaa09ce714e81a66
Autor:
Navasona Krishnan, Christopher A. Bonham, Ioana A. Rus, Om Kumar Shrestha, Carla M. Gauss, Aftabul Haque, Ante Tocilj, Leemor Joshua-Tor, Nicholas K. Tonks
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
The activity of protein tyrosine phosphatase PTP1B, a major metabolic regulator, depends on its oxidation state. Here the authors identify and characterize a small molecule that targets the oxidized, inactive form of PTP1B, suggesting a new therapeut
Externí odkaz:
https://doaj.org/article/ba9c741928c64ecab9592a1665278839
Autor:
Sujatha M. Gopalakrishnan, Xiaoying Chen, Diana Donnelly-Roberts, Navasona Krishnan, Eric G. Mohler, David M. Holtzman
Publikováno v:
ACS chemical biology. 15(12)
Alzheimer's Disease (AD) is a progressive neurodegenerative disease and the most common cause of dementia. The current treatment options for AD are limited to ameliorating cognitive decline temporarily and not reversing or preventing the progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e84187dcac144f43e8e1825080107c7
https://pubmed.ncbi.nlm.nih.gov/33270420
https://pubmed.ncbi.nlm.nih.gov/33270420
Autor:
Christopher A. Bonham, Nicholas K. Tonks, Leemor Joshua-Tor, Om Kumar Shrestha, Ioana A. Rus, Aftabul Haque, Ante Tocilj, Carla M. Gauss, Navasona Krishnan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications
Nature Communications
The protein tyrosine phosphatase PTP1B is a major regulator of glucose homeostasis and energy metabolism, and a validated target for therapeutic intervention in diabetes and obesity. Nevertheless, it is a challenging target for inhibitor development.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa31ecacee39a769842172de512aff52
https://doaj.org/article/ba9c741928c64ecab9592a1665278839
https://doaj.org/article/ba9c741928c64ecab9592a1665278839
The levels of copper, which is an essential element in living organisms, are under tight homeostatic control. Inactivating mutations in ATP7B, a P-type Cu-ATPase that functions in copper excretion, promote aberrant accumulation of the metal, primaril
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ce28d089be2a215302b36a940f4047
https://europepmc.org/articles/PMC6075031/
https://europepmc.org/articles/PMC6075031/
Publikováno v:
Journal of Biological Chemistry. 290:9646-9659
Background: The role of protein-tyrosine phosphatases (PTP) in ERBB2 signaling is undefined. Results: Phosphatidic acid (PA) activated PTPD2; inhibition of PA production or PTPD2 expression attenuated ERBB2-mediated morphological changes in mammary e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2580f8131b41e400886422841cfab2
https://doi.org/10.1074/jbc.m114.627968
https://doi.org/10.1074/jbc.m114.627968
Publikováno v:
The Journal of biological chemistry. 293(5)
The protein-tyrosine phosphatase PTP1B is a negative regulator of insulin and leptin signaling and a highly validated therapeutic target for diabetes and obesity. Conventional approaches to drug development have produced potent and specific PTP1B inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a8572c09e7c38f82597e26255957b93
https://pubmed.ncbi.nlm.nih.gov/29217773
https://pubmed.ncbi.nlm.nih.gov/29217773
Autor:
Tommi A. White, Dhiraj Srivastava, Jonathan P. Schuermann, Anmin Tan, Navasona Krishnan, Nikhilesh Sanyal, Donald F. Becker, John J. Tanner, Michael T. Henzl, Greg L. Hura
Publikováno v:
Proceedings of the National Academy of Sciences. 107:2878-2883
The bifunctional proline catabolic flavoenzyme, proline utilization A (PutA), catalyzes the oxidation of proline to glutamate via the sequential activities of FAD-dependent proline dehydrogenase (PRODH) and NAD + -dependent Δ 1 -pyrroline-5-carboxyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09fb252963b38eabe96365256f1a489
https://doi.org/10.1073/pnas.0906101107
https://doi.org/10.1073/pnas.0906101107
Autor:
Dae Gwin Jeong, Seung Jun Kim, Seong Eon Ryu, Navasona Krishnan, C. David Allis, Nicholas K. Tonks, Suk-Kyeong Jung, Andrew Xiao
Publikováno v:
Journal of Biological Chemistry. 284:16066-16070
In mammalian cells, the DNA damage-related histone H2A variant H2A.X is characterized by a C-terminal tyrosyl residue, Tyr-142, which is phosphorylated by an atypical kinase, WSTF. The phosphorylation status of Tyr-142 in H2A.X has been shown to be a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abad911220779e46304d921e643396ab
https://doi.org/10.1074/jbc.c900032200
https://doi.org/10.1074/jbc.c900032200