Use of kinase inhibitors for the preparation of pharmaceutical compositions for treatment of Parkinson's disease, pharmaceutical compositions and diagnostic procedure for Parkinson's disease

Autor: Navarro Hilfiker, Sabine, Rubio de la Torre, Elena

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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[EN] The present invention describes the direct relationship between the phosphorylation of the parkin protein and the formation of intracellular aggregates in neurons. Consequently inhibitors of casein kinase 1 and Cdk5 can be useful pharmaceutical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::6e08bce22ebd931b53efa813136d9dc6
http://hdl.handle.net/10261/27848

Centrosomal defects caused by the Parkinson’s disease associated protein kinase LRRK2 and Rab proteins

Autor: Madero Pérez, Jesús

Publikováno v: Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Digibug. Repositorio Institucional de la Universidad de Granada
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Mutations in the leucine rich repeat kinase 2 (LRRK2) gene are the most common cause of familial Parkinson’s disease (PD), with autosomal-dominant inheritance, and variants in this gene also confer risk to develop sporadic PD. Whilst the cellular a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::cc2e5cb5688dc869d3c57b75c0afa061
http://hdl.handle.net/10481/67459

Structural determinants for SNARE-mediated neurosecretion

Autor: Fernández Fernández, Elena

Tesis Consejo Superior de Investigaciones Científicas. Instituto de Parasitología y Biomedicina López Neyra
Tesis Univ. Granada. Departamento de Bioquímica y Biología Molecular. Leída el 9 de octubre de 2009

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f4096598bfacac7c289d529d5755469b
http://hdl.handle.net/10481/2708

Analysis of LRRK2 Towards understanding the pathogenic mechanisms underlying parkinson's disease: Deregulated autophagy and endocytosis

Autor: Gómez Suaga, Patricia María

Publikováno v: Digibug. Repositorio Institucional de la Universidad de Granada
instname

Although the majority of PD cases are idiopathic, the identification of diseasecausing mutations helps in our understanding of the molecular mechanisms involved in neuronal demise. Mutations in LRRK2 (leucine-rich repeat kinase 2) are found associate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::240a6fb24a156e4e6eb62a1e3c5bd53c
http://hdl.handle.net/10481/45093