Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Navaneethan Radhakrishnan"'
Autor:
Cheng-Yu Tsai, Ying-Chang Lu, Yen-Hui Chan, Navaneethan Radhakrishnan, Yuan-Yu Chang, Shu-Wha Lin, Tien-Chen Liu, Chuan-Jen Hsu, Pei-Lung Chen, Lee-Wei Yang, Chen-Chi Wu
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 5698-5711 (2023)
Variants in the gap junction beta-2 (GJB2) gene are the most common cause of hereditary hearing impairment. However, how GJB2 variants lead to local physicochemical and structural changes in the hexameric ion channels of connexin 26 (Cx26), resulting
Externí odkaz:
https://doaj.org/article/4cc6f64e81f44b9c8a1e0e677fb5c287
Autor:
Navaneethan Radhakrishnan, Jaspreet Kaur Dhanjal, Anissa Nofita Sari, Yoshiyuki Ishida, Keiji Terao, Sunil C. Kaul, Durai Sundar, Renu Wadhwa
Publikováno v:
Discover Oncology, Vol 12, Iss 1, Pp 1-13 (2021)
Abstract Mutations in the tumor suppressor protein p53 is a prevalent feature in majority of cancers resulting in inactivation of its activities related to control of cell cycle progression and proliferation. p53Y220C is one of the common hotspot mut
Externí odkaz:
https://doaj.org/article/58648425285e45aeaf612d98249ad08e
Publikováno v:
Membranes, Vol 12, Iss 1, p 64 (2022)
Development of drugs that are selectively toxic to cancer cells and safe to normal cells is crucial in cancer treatment. Evaluation of membrane permeability is a key metric for successful drug development. In this study, we have used in silico molecu
Externí odkaz:
https://doaj.org/article/ae8d321ca7854a4cb008e782afb9b4cd
Publikováno v:
Biomolecules, Vol 12, Iss 2, p 212 (2022)
Withaferin-A (Wi-A), a secondary metabolite extracted from Ashwagandha (Withania somnifera), has been shown to possess anticancer activity. However, the molecular mechanism of its action and the signaling pathways have not yet been fully explored. We
Externí odkaz:
https://doaj.org/article/f056a2f1aa2c460d9e471c871ffff270
Autor:
Sukant Garg, Sajal Afzal, Ahmed Elwakeel, Damini Sharma, Navaneethan Radhakrishnan, Jaspreet Kaur Dhanjal, Durai Sundar, Sunil C. Kaul, Renu Wadhwa
Publikováno v:
Marine Drugs, Vol 17, Iss 6, p 338 (2019)
Fucoxanthin is commonly found in marine organisms; however, to date, it has been one of the scarcely explored natural compounds. We investigated its activities in human cancer cell culture-based viability, migration, and molecular assays, and found t
Externí odkaz:
https://doaj.org/article/ea203918373848298f4545ef52aad933
Publikováno v:
Microbial Systems Biology ISBN: 9781071615843
The easily programmable CRISPR/Cas9 system has found applications in biomedical research as well as microbial and crop applications, due to its ability to create site-specific edits. This powerful and flexible system has also been modified to enable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fbdb258ce400e460d70445d2cda047d
https://doi.org/10.1007/978-1-0716-1585-0_8
https://doi.org/10.1007/978-1-0716-1585-0_8
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2349
The easily programmable CRISPR/Cas9 system has found applications in biomedical research as well as microbial and crop applications, due to its ability to create site-specific edits. This powerful and flexible system has also been modified to enable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::267e783d2af69304adc18ee91d88463d
https://pubmed.ncbi.nlm.nih.gov/34718995
https://pubmed.ncbi.nlm.nih.gov/34718995
CRISPcut: A novel tool for designing optimal sgRNAs for CRISPR/Cas9 based experiments in human cells
Publikováno v:
Genomics. 111:560-566
The ability to direct the CRISPR/Cas9 nuclease to a unique target site within a genome would have broad use in targeted genome engineering. However, CRISPR RNA is reported to bind to other genomic locations that differ from the intended target site b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fbacb1c761de7920c44217e1605a5c9
https://doi.org/10.1016/j.ygeno.2018.03.011
https://doi.org/10.1016/j.ygeno.2018.03.011
Autor:
Yoshiyuki Ishida, Jaspreet Kaur Dhanjal, Renu Wadhwa, Priyanshu Bhargava, seyad shefrin, Anissa Nofita Sari, Jayarani F. Putri, Keiji Terao, Sunil C. Kaul, Navaneethan Radhakrishnan, Durai Sundar
Publikováno v:
Cancers
Volume 12
Issue 5
Cancers, Vol 12, Iss 1160, p 1160 (2020)
Volume 12
Issue 5
Cancers, Vol 12, Iss 1160, p 1160 (2020)
We have earlier reported anticancer activity in Withaferin A (Wi-A), a withanolide derived from Ashwagandha (Withania somnifera) and caffeic acid phenethyl ester (CAPE), an active compound from New Zealand honeybee propolis. Whereas Wi-A was cytotoxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc0095d2baa21175bac67967816c453
Publikováno v:
Methods. 131:66-73
Synthetic lethality occurs when co-occurrence of two genetic events is unfavorable for the survival of the cell or organism. The conventional approach of high throughput screening of synthetic lethal targets using chemical compounds has been replaced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc4978ab32dd4a2742ddad0a83c9333
https://doi.org/10.1016/j.ymeth.2017.07.007
https://doi.org/10.1016/j.ymeth.2017.07.007