The disulfide catalyst QSOX1 maintains the colon mucosal barrier by regulating Golgi glycosyltransferases

Autor: Tal Ilani, Nava Reznik, Noa Yeshaya, Tal Feldman, Patrick Vilela, Zipora Lansky, Gabriel Javitt, Michal Shemesh, Ori Brenner, Yoav Elkis, Neta Varsano, Ana M Jaramillo, Christopher M Evans, Deborah Fass

Publikováno v: The EMBO journalReferences.

Mucus is made of enormous mucin glycoproteins that polymerize by disulfide crosslinking in the Golgi apparatus. QSOX1 is a catalyst of disulfide bond formation localized to the Golgi. Both QSOX1 and mucins are highly expressed in goblet cells of muco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eef1db9ed0af08f52d5105e24659d31
https://pubmed.ncbi.nlm.nih.gov/36245281

Conformational switches and redox properties of the colon cancer‐associated human lectin ZG16

Autor: Alisa Kinzel, Gabriel Javitt, Nava Reznik, Deborah Fass

Publikováno v: 'FEBS Journal ', vol: 288, pages: 6465-6475 (2021)

Zymogen granule membrane protein 16 (ZG16) is produced in organs that secrete large quantities of enzymes and other proteins into the digestive tract. ZG16 binds microbial pathogens, and lower ZG16 expression levels correlate with colorectal cancer,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c9a7b1fb42bc0c9061ee7ced77d0011
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:58261

Intestinal mucin is a chaperone of multivalent copper

Autor: Nava Reznik, Annastassia D. Gallo, Katherine W. Rush, Gabriel Javitt, Yael Fridmann-Sirkis, Tal Ilani, Noa A. Nairner, Simon Fishilevich, David Gokhman, Kelly N. Chacón, Katherine J. Franz, Deborah Fass

Publikováno v: Cell. 185(22)

Mucus protects the epithelial cells of the digestive and respiratory tracts from pathogens and other hazards. Progress in determining the molecular mechanisms of mucus barrier function has been limited by the lack of high-resolution structural inform

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aab9ad2121d92f46a07c989ccae615b
https://pubmed.ncbi.nlm.nih.gov/36206754

Intestinal gel-forming mucins polymerize by disulfide-mediated dimerization of D3 domains

Autor: Gabriel Javitt, Deborah Fass, Lis Albert, María Luisa Gómez Calvo, Tal Ilani, Nava Reznik, Ron Diskin

Publikováno v: 'Journal of Molecular Biology ', vol: 431, pages: 3740-3752 (2019)
Journal of Molecular Biology

The mucin 2 glycoprotein assembles into a complex hydrogel that protects intestinal epithelia and houses the gut microbiome. A major step in mucin 2 assembly is further multimerization of preformed mucin dimers, thought to produce a honeycomb-like ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e84c6ff1eff976a6371c3ec43881b922
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:54167

Rapid covalent-probe discovery by electrophile-fragment screening

Autor: Alexander N. Plotnikov, Haim Barr, S. Velupillai, T. Krojer, Jingxu Guo, Jinrui Gan, Huib Ovaa, Oleg Fedorov, Christopher G. Dowson, Gian Filippo Ruda, R. Sethi, Chu Wang, Michael Fairhead, Ronen Gabizon, Nava Reznik, Gabriel Amitai, Daniel Zaidman, T. Szommer, James Bennett, Dom Bellini, Nir London, Paul P. Geurink, Efrat Resnick, Anthony Aimon, Verena M. Straub, Anthony R. Bradley, Frank von Delft, Y. Zhang, Alun R. Coker, Alice Douangamath, Laura Diaz Saez, Paul Brennan, Kilian Huber, Jin Gan

Publikováno v: Journal of the American Chemical Society, 141(22), 8951-8968
Journal of the American Chemical Society, 141(22), 8951-8968. AMER CHEMICAL SOC

[Image: see text] Covalent probes can display unmatched potency, selectivity, and duration of action; however, their discovery is challenging. In principle, fragments that can irreversibly bind their target can overcome the low affinity that limits r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc5c370637dd62cafe589b277a9c578
http://wrap.warwick.ac.uk/119286/1/WRAP-rapid-covalent-probe-discovery-electrophile-fragment-screening-Dowson-2019.pdf