Multimodal Imaging with NanoGd Reveals Spatiotemporal Features of Neuroinflammation after Experimental Stroke

Autor: Violaine Hubert, Ines Hristovska, Szilvia Karpati, Sarah Benkeder, Arindam Dey, Chloé Dumot, Camille Amaz, Naura Chounlamountri, Chantal Watrin, Jean‐Christophe Comte, Fabien Chauveau, Emmanuel Brun, Patrice Marche, Fréderic Lerouge, Stéphane Parola, Yves Berthezène, Thomas Vorup‐Jensen, Olivier Pascual, Marlène Wiart

Publikováno v: Advanced Science, Vol 8, Iss 17, Pp n/a-n/a (2021)

Abstract The purpose of this study is to propose and validate a preclinical in vivo magnetic resonance imaging (MRI) tool to monitor neuroinflammation following ischemic stroke, based on injection of a novel multimodal nanoprobe, NanoGd, specifically

Externí odkaz: https://doaj.org/article/f020051bb7dc446d96034a929c8594a1

Supplemental Figure S4 from CRMP5 Controls Glioblastoma Cell Proliferation and Survival through Notch-Dependent Signaling

Autor: Nicole Thomasset, David Meyronet, François Ducray, Rajesh Khanna, Léa Magadoux, Nicolas Naudet, Roger Besançon, Marie-Eve Mayeur, Naura Chounlamountri, Chantal Watrin, Céline Malleval, Caroline Bertrand, Pauline Désormeaux, Patrick Massoma, Jérôme Honnorat, Aubin Moutal

CRMP5 depletion does not promote apoptosis.(A): Apoptosis is monitored in GL15 cells transfected with CRMP5-siRNA1 and control-siRNA using caspase 3 antibody (1/400, BD Pharmingen, 559565). 5-bromo-2'-deoxyuridine (BrdU) indicates proliferating cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8b676c0502909bc5b1a040f5fc71f2
https://doi.org/10.1158/0008-5472.22405920

Cerebellar Ataxia With Anti-DNER Antibodies: Outcomes and Immunologic Features

Autor: Elise Peter, Le Duy Do, Salem Hannoun, Sergio Muñiz-Castrillo, Alberto Vogrig, Valentin Wucher, Anne-Laurie Pinto, Naura Chounlamountri, Walaa Zakaria, Veronique Rogemond, Geraldine Picard, Julien-Jacques Hedou, Aditya Ambati, Agusti Alentorn, Alexandra Traverse-Glehen, Mario Manto, Dimitri Psimaras, Emmanuel Mignot, Francois Cotton, Virginie Desestret, Jérôme Honnorat, Bastien Joubert

Publikováno v: Neurology(R) neuroimmunologyneuroinflammation. 9(5)

Background and ObjectivesThere is no report on the long-term outcomes of ataxia with antibodies against Delta and Notch-like epidermal growth factor–related (DNER). We aimed to describe the clinical-immunologic features and long-term outcomes of pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac9fdc4b774096267adddf4ffafa54b
https://pubmed.ncbi.nlm.nih.gov/35940913

VEGF counteracts amyloid-β-induced synaptic dysfunction

Autor: Laurent, Martin, Pauline, Bouvet, Naura, Chounlamountri, Chantal, Watrin, Roger, Besançon, Delphine, Pinatel, David, Meyronet, Jérôme, Honnorat, Alain, Buisson, Paul-Antoine, Salin, Claire, Meissirel

Publikováno v: Cell Reports
Cell Reports, 2021, 35 (6), pp.109121. ⟨10.1016/j.celrep.2021.109121⟩
Cell Reports, Elsevier Inc, 2021, 35 (6), pp.109121. ⟨10.1016/j.celrep.2021.109121⟩

International audience; The vascular endothelial growth factor (VEGF) pathway regulates key processes in synapse function, which are disrupted in early stages of Alzheimer's disease (AD) by toxic-soluble amyloid-beta oligomers (Aβo). Here, we show t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::014e70793f3095353d487f7900218a92
https://pubmed.ncbi.nlm.nih.gov/33979625

CRMP5 Controls Glioblastoma Cell Proliferation and Survival through Notch-Dependent Signaling

Autor: Chantal Watrin, Nicolas Naudet, Patrick Massoma, Aubin Moutal, Rajesh Khanna, Marie Eve Mayeur, Nicole Thomasset, Léa Magadoux, Naura Chounlamountri, Roger Besançon, Caroline Bertrand, François Ducray, Céline Malleval, Pauline Désormeaux, Jérôme Honnorat, David Meyronet

Publikováno v: Cancer Research. 75:3519-3528

Collapsin response mediator protein 5 (CRMP5) belongs to a family of five cytosolic proteins that play a major role in nervous system development. This protein was first described in cancer-induced autoimmune processes, causing neurodegenerative diso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f732c14fd752a1c37b7e4767c516538
https://doi.org/10.1158/0008-5472.can-14-0631