The synthesis of cis- and trans-3-(4-hydroxyphenyl)cyclobutanecarboxylic acids and the study of their derivatives as GPR-40 receptor ligands

Autor: Feskov, I. O., Kondratov, I. S., Kuchkovska, Yu. O., Naumchyk, V. S., Onopchenko, O. V., Grygorenko, O. O.

Publikováno v: Журнал органічної та фармацевтичної хімії; Том 18, № 4(72) (2020); 14-22
Journal of Organic and Pharmaceutical Chemistry; Том 18, № 4(72) (2020); 14-22
Журнал органической и фармацевтической химии; Том 18, № 4(72) (2020); 14-22

Aim. To synthesize cis- and trans-isomers of 3-(4-hydroxyphenyl)cyclobutanecarboxylic acid and evaluate the biological activity of their derivatives against GPR-40.Results and discussion. Cis- and trans-isomers of 3-(4-hydroxyphenyl)cyclobutanecarbox

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http://ophcj.nuph.edu.ua/article/view/ophcj.20.210383